The BEST episodes of Grey's Anatomy season 6

Every episode of Grey's Anatomy season 6, ranked from best to worst by thousands of votes from fans of the show. The best episodes of Grey's Anatomy season 6!

A drama centered on the personal and professional lives of five surgical interns and their supervisors.

Last Updated: 4/22/2024Network: ABC (US)Status: Continuing
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Death and All His Friends
star
8.30
3391 votes

#1 - Death and All His Friends

Season 6 - Episode 24 - Aired 5/20/2010

Cristina and Meredith's surgical skills are put to the ultimate test.

Directors: Rob Corn
Watch Now:AmazonApple TV
Sanctuary
star
8.20
3202 votes

#2 - Sanctuary

Season 6 - Episode 23 - Aired 5/20/2010

Seattle Grace Hospital is hit with a crisis like no other in its' history.

Directors: Stephen Cragg
Watch Now:AmazonApple TV
The Time Warp
star
7.76
2811 votes

#3 - The Time Warp

Season 6 - Episode 15 - Aired 2/18/2010

In his new role as Chief, Derek restores the hospital lecture series, and Richard, Bailey and Callie present to the group pivotal surgical cases from their pasts Bailey reflects on her first days as a shy resident, Callie looks back on a polio case, and Richard recalls a case in which he and Ellis worked on a patient diagnosed with GRID, a virus later called AIDS.

Directors: Rob Corn
Writer: Zoanne Clack
Watch Now:AmazonApple TV
Invest in Love
star
7.71
2121 votes

#4 - Invest in Love

Season 6 - Episode 8 - Aired 11/5/2009

A generous 25 million donation is offered to Seattle Grace by the parents of Arizonas 10-year-old patient, she finds herself in a conflict of interest when his condition worsens. Cristina tests her boundaries with Owen at the hospital. Alex is left with all of Izzies hospital bills to contend with.

Directors: Jessica Yu
Watch Now:AmazonApple TV
Tainted Obligation
star
7.64
2085 votes

#5 - Tainted Obligation

Season 6 - Episode 4 - Aired 10/8/2009

When Meredith and Lexie's father, Thatcher, returns to the hospital with a failed liver, it's up to Meredith to save his life. Meanwhile, Izzie empathizes with a patient riddled with tumors, as Mark, annoyed with Cristina's competitive zeal, tricks her into assisting on an unusual surgery.

Directors: Tom Verica
Writer: Jenna Bans
Watch Now:Apple TV
Give Peace a Chance
star
7.64
2150 votes

#6 - Give Peace a Chance

Season 6 - Episode 7 - Aired 10/29/2009

When Isaac has an inoperable tumor wrapped around his spine, he wants Derek to do the impossible. Derek tests the Chief's authority when Richard objects to moving forward with the risky surgery.

Directors: Chandra Wilson
Writer: Peter Nowalk
Watch Now:Apple TV
I Saw What I Saw
star
7.59
1970 votes

#7 - I Saw What I Saw

Season 6 - Episode 6 - Aired 10/22/2009

After a burn victim unexpectedly dies in the midst of a chaotic ER, the Chief and board member Jennings interrogate the residents to find the culprit, as all the Mercy West and Seattle Grace resident defends their actions in an effort to save their jobs.

Watch Now:Apple TV
Valentine's Day Massacre
star
7.49
2570 votes

#8 - Valentine's Day Massacre

Season 6 - Episode 14 - Aired 2/11/2010

It's Valentine's Day, and the doctors must treat dozens of injured people after the roof collapses at a popular romantic restaurant; Derek tries to manage his busy schedule as Chief of Surgery; Meredith wrestles with her new duties as the Chief's wife; and Mark and Callie team up to convince Sloan to do the right thing for her baby.

Directors: Stephen Cragg
Watch Now:Apple TV
Push
star
7.46
2980 votes

#9 - Push

Season 6 - Episode 17 - Aired 3/11/2010

A patient who needs an extremely difficult surgery comes to Seattle Grace, and it's Richard and Owen who vie for the opportunity to tackle it. But the decision lies in the hands of Derek, who deems that Owen should take on the surgery, leaving Richard bitter. Meanwhile, Bailey deals with her own personal struggles when she nervously prepares for another date with Ben.

Directors: Chandra Wilson
Writer: Debora Cahn
Watch Now:Apple TV
I Always Feel Like Somebody's Watchin' Me
star
7.45
1880 votes

#10 - I Always Feel Like Somebody's Watchin' Me

Season 6 - Episode 3 - Aired 10/1/2009

Several weeks after her near-death experience, a recovering Izzie returns to work. Meanwhile, nervous that there will be layoffs in the hospital in the wake of an announcement from the Chief, the Seattle Grace residents compete to survive the cuts, including Cristina, who attempts to work alongside Arizona in pediatrics. And Bailey and Alex's patient's already complex case is further complicated by her schizophrenic son.

Directors: Michael Pressman
Watch Now:Apple TV
Invasion
star
7.44
2085 votes

#11 - Invasion

Season 6 - Episode 5 - Aired 10/15/2009

The residents of Seattle Grace and Mercy West vie for surgeries and their careers as day one of the hospital merger begins. Meanwhile, Arizona stands by an enraged Callie when her father, Mr. Torres, employs a priest to help convince her to date men, and Izzie experiences the brunt of her new surgical competition.

Directors: Tony Phelan
Writer: Mark Wilding
Watch Now:Apple TV
Suicide Is Painless
star
7.42
3145 votes

#12 - Suicide Is Painless

Season 6 - Episode 18 - Aired 3/25/2010

When Teddy's patient seeks to end treatment and her life, she turns to Hunt for help. The situation triggers Hunt's memories of his life at war and his past relationship with Teddy. Meanwhile, Callie and Arizona have a difference in opinion on what their future holds, and Richard tries to adjust to his role as a surgeon.

Directors: Jeannot Szwarc
Watch Now:Apple TV
New History
star
7.41
1992 votes

#13 - New History

Season 6 - Episode 9 - Aired 11/12/2009

Owen recruits Dr. Teddy Altman, a former Iraqi veteran, as the new cardiothoracic surgeon. Cristina questions her abilities in the E.R. and relationship with Owen. Izzie returns to Seattle Grace with her high school mentor seeking treatment for his dementia. Richard's responsibilities, post-merger, are taking a toll on him.

Directors: Rob Corn
Watch Now:Apple TV
Blink
star
7.41
2356 votes

#14 - Blink

Season 6 - Episode 11 - Aired 1/14/2010

Mark flies Addison to Seattle to help with a difficult procedure on his pregnant daughter, Sloan, Owen questions Teddy's motives when she assigns Cristina the lead on a complicated surgery, and Derek's suspicions are raised when the Chief recruits Meredith to assist with a high profile operation on.

Directors: Randy Zisk
Writer: Debora Cahn
Watch Now:Apple TV
Perfect Little Accident
star
7.40
2901 votes

#15 - Perfect Little Accident

Season 6 - Episode 16 - Aired 3/4/2010

When famous surgeon Dr. Harper Avery is rushed to Seattle Grace-Mercy West, the staff is surprised to discover that one of their own is related to this legend, and his unorthodox request for his surgery causes tensions t between Derek and Richard. Meanwhile Callie and Arizona try to help Teddy and Sloan move on from their pasts and find greener pastures.

Directors: Bill D'Elia
Writer: Peter Nowalk
Watch Now:Apple TV
Shiny Happy People
star
7.38
3263 votes

#16 - Shiny Happy People

Season 6 - Episode 22 - Aired 5/13/2010

An elderly patient admitted into the E.R. for a heart condition sees a familiar face, a long lost love who happens to be in the E.R. as well for a fractured arm, and the staff find themselves caught up in their love story. Meanwhile, Karev treats a troubled teenage patient (guest star Demi Lovato) whose parents brought her in for schizophrenia, and Meredith can't help but tell Cristina about her suspicions of Owen -- which inevitably messes with Cristina's head.

Directors: Edward Ornelas
Watch Now:Apple TV
Holidaze
star
7.37
1990 votes

#17 - Holidaze

Season 6 - Episode 10 - Aired 11/19/2009

As Thanksgiving, Christmas and New Year's pass, Miranda gets a visit from her father, William who disapproves of her choices in life. Mark and Lexie cope with an arrival of a woman from his past. Thatcher questions the Chief's recent behavior as Meredith comes to his defense.

Directors: Robert Berlinger
Watch Now:Apple TV
Goodbye
star
7.37
1346 votes

#18 - Goodbye

Season 6 - Episode 2 - Aired 9/24/2009

Everyone is struggling after losing one of their own and are turning to any distraction they can find. Meredith and Derek seem to be consummating their marriage anywhere and everywhere, while Cristina and Owen have been instructed to abstain from sex by Dr. Wyatt.

Directors: Bill D'Elia
Watch Now:Apple TV
Good Mourning
star
7.36
2146 votes

#19 - Good Mourning

Season 6 - Episode 1 - Aired 9/24/2009

The hospital staff is left to deal with the aftermath of George's passing. Hitting the staff hard, they all find unique ways to get through the various stages of grief. George's mom returns, faced with the difficult task of deciding what to do with his organs.

Directors: Edward Ornelas
Watch Now:Apple TV
Hook, Line, and Sinner
star
7.35
3017 votes

#20 - Hook, Line, and Sinner

Season 6 - Episode 20 - Aired 4/29/2010

Sloan returns to Mark's apartment, just as she's going into labor, and Teddy, Mark and the still-fighting Callie and Arizona are there to help with the birth and to get Mark through his grandson's pending adoption. Meanwhile Teddy sees Derek's invitation to illustrious cardiothoracic surgeon Tom Evans' as a threat to her future employment at the hospital, and the team work on a crab boat captain who has been stabbed with a giant shark hook.

Directors: Tony Phelan
Writer: Meg Marinis
Watch Now:Apple TV
I Like You So Much Better When You're Naked
star
7.34
2381 votes

#21 - I Like You So Much Better When You're Naked

Season 6 - Episode 12 - Aired 1/21/2010

After learning of Richard's drinking problem, Derek confronts him for the sake of his friend and the hospital, Izzie returns, hoping to reconcile with Alex, and tensions run high between Teddy, Cristina and Owen in the aftermath of Cristina's startling confession.

Directors: Donna Deitch
Watch Now:Apple TV
State of Love and Trust
star
7.33
2452 votes

#22 - State of Love and Trust

Season 6 - Episode 13 - Aired 2/4/2010

As Derek begins his role as interim chief, he faces a potential lawsuit when Bailey and Meredith's patient awakens from anesthesia mid-surgery. Meanwhile, Teddy refuses to place Cristina on her service, as Arizona tests Alex out in Pediatrics, and Mark refuses to speak to a heartbroken Lexie.

Directors: Jeannot Szwarc
Writer: Stacy McKee
Watch Now:Apple TV
How Insensitive
star
7.31
3215 votes

#23 - How Insensitive

Season 6 - Episode 21 - Aired 5/6/2010

Bailey preps the team with mandatory sensitivity training prior to admitting a 700-pound patient with compounded medical issues, and the case proves to be challenging in every sense of the word. Meanwhile Derek has to come face to face with a former patient's husband in a wrongful death deposition, and spending time with a heart patient's daughter opens up some old wounds for Cristina.

Directors: Tom Verica
Watch Now:Apple TV
Sympathy for the Parents
star
7.29
3086 votes

#24 - Sympathy for the Parents

Season 6 - Episode 19 - Aired 4/1/2010

When Alex's younger brother, Aaron, shows up at Seattle Grace-Mercy West with a hernia, it's up to Alex to get Bailey's approval for his pro bono surgery. Matters are further complicated when Aaron discloses that his family has not heard from Alex since he arrived in Seattle, and parts of Alex's past long kept secret are revealed to his friends and fellow doctors.

Directors: Debbie Allen
Watch Now:Apple TV