The BEST Episodes of Medical Investigation

Every episode ever - ranked by fan votes!

Last Updated: May 14, 2021

Network: NBC

Neal McDonough (NBC's Boomtown) and Kelli Williams (The Practice) return to series television as members of a mobile medical team from the National Institutes of Health (NIH) who are summoned in a heartbeat to scope out -- and hopefully snuff out -- outbreaks of unexplained and fearful diseases. These specialists drop out of the sky anywhere and have government carte blanche to take charge when people start dying, which requires them to medically re-construct grisly events to prevent the next epidemic, plague or contagion. McDonough stars as Dr. Stephen Connor, the leader of the team whose take-charge attitude has enabled him to save the lives of millions, but in the process, has sadly cost the separated Connor his family. Williams portrays Dr. Natalie Durant, who specializes in pathology and epidemiology and works under the supervision of Connor, a man whom she respects, but is willing to stand up to in any life-threatening situation. The elite team also includes Troy Winb

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The Unclean

#1 - The Unclean

Season 1 - Episode 11 - Aired Dec 3, 2004

An "Angel of Death" runs amok in a hospital, spreading a deadly flesh-eating virus, which kills patients. Now it is up to the NIH to stop this lunatic, who has a past that they should not be proud of.

star 7.43
87 votes
Directors: Elodie Keene
Writers: Mark Dodson

#2 - Mutation

Season 1 - Episode 8 - Aired Nov 5, 2004

The team flies to a small Virgina town to figure out why people are dying from a deadly strain of the flu.

star 7.42
86 votes
Directors: Marc Buckland
Writers: David Graziano
Little Girl

#3 - Little Girl

Season 1 - Episode 9 - Aired Nov 12, 2004

After the victims of a car accident are diagnosed with a deadly disease, which caused the accident, a small Maryland town requests the assistance of the NIH team. The only problem is there is only one living victim, as the other nine victims had perished, and in order to save her life, and find the cure, she requires a bone marrow transplant. This little girls runs out of luck as her father has died from the same disease and her mother died from a drug overdose. However, Natalie does some DNA tests to see if the bone marrow can still be used, and discovers the girl was adopted. Eva then then goes and searches for the girl's birth mother, who wants no part in the girl's life. After some tough convincing, Eva gets the mother to donate, and saves the girls life. Now, in order to find the cause for the epidemic, the team must look to some tainted seafood for the answer.

star 7.40
86 votes
Directors: Paul Holahan
Writers: Craig Van Sickle, Steven Long Mitchell
Price of Pleasure

#4 - Price of Pleasure

Season 1 - Episode 10 - Aired Nov 19, 2004

When the adult film stars in Los Angeles start falling prey to a devastating disease, the hospital summons the assistance of the NIH team. At first, being as they are adult film stars, Connor suspects an STD. However, when the perfect housewife also falls prey to the same illness, a new link is needed to be found. After some testing, it is discovered that all of the women used the same plastic surgeon for breast implants. The team contacts the doctor, who is reluctant to help, but finally convince him to abide. The team tests the implants, but finds nothing. After some tough thinking, the team realizes that some fish and some water hold the answer.

star 7.37
112 votes
Directors: Norberto Barba
Writers: Juan Carlos Coto

#5 - Alienation

Season 1 - Episode 7 - Aired Oct 29, 2004

The team flies to Philadelphia to figure out if Anthrax is showing up as a result of terrorism or not.

star 7.36
88 votes
Directors: Mike Fresco
Writers: Ayanna Floyd

#6 - Spiked

Season 1 - Episode 12 - Aired Jan 7, 2005

A surfer and volleyball player from a seaside town catch a mysterious disease. Dr. Connor and his staff begin suspecting that nearby seals played a part in this illness, however are the other forces at play?

star 7.19
59 votes
Directors: Tucker Gates
Writers: Peter Egan
The Black Book

#7 - The Black Book

Season 1 - Episode 18 - Aired Feb 25, 2005

Connor suspects terrorism when two congressmen and an officer fall prey to an unknown disease. However, when the leader of a prostitution ring becomes ill with the same symptoms, an unknown STD becomes the suspected agent. Now it is a race against the clock, and their pesky boss, Dr. Ewing, to find a call girl who may be the source of this deadly outbreak.

star 7.19
59 votes
Directors: Elodie Keene
Writers: Michael B. Silver
Half Life (2)

#8 - Half Life (2)

Season 1 - Episode 17 - Aired Feb 18, 2005

The NIH team teams up with the officers of the 55th Precinct in New York City to try to figure out what is the source of an outbreak of Marburg, a deadly disease with no known cure. They also try to locate patient zero, a murder suspect on the run, who is helping to spread the disease throughout New York City. (In the Family Way (1) aired on Third Watch, season 6, episode 16.)

star 7.17
63 votes
Directors: Roxann Dawson
Writers: David Ehrman
In Bloom

#9 - In Bloom

Season 1 - Episode 2 - Aired Sep 10, 2004

A group of four teenage girls are suspected of having an STD when they are hospitalized for seizures. However, the NIH team must uncover the true cause of the seizures, and a pair of pants holds a clue.

star 7.13
88 votes
Directors: Marc Buckland
Writers: Jason Horwitch
Coming Home

#10 - Coming Home

Season 1 - Episode 3 - Aired Sep 17, 2004

When a couple of Iraqi War vets start showing signs of Gulf War Syndrome, the NIH team is called to investigate. However, when a group of Nursing-home residents fall ill with the same symptoms, the NIH team is left baffled. However, they are missing the bigger picture, where a lector holds an important clue.

star 7.12
114 votes
Directors: Rick Wallace
Writers: Mark Israel

#11 - Progeny

Season 1 - Episode 5 - Aired Oct 1, 2004

After years of watching young children fall prey to a crippling muscular ailment, a small community summons the NIH team to hopefully find a cure. At first, Connor suspects a local chemical plant as being the cause of this devestating. However, a common link is discovered, and the DNA of the children holds an important clue.

star 7.12
85 votes
Directors: Rick Wallace
Writers: Barry M. Schkolnick
Mission La Roca (2)

#12 - Mission La Roca (2)

Season 1 - Episode 20 - Aired Mar 25, 2005

The team figures out that they are dealing with bacterial meningitis, and the only thing that makes their day worse is a corrupt politician who steals the medicine and holds it at ransom. Elsewhere, the people at Mission La Roca (Miles, Connor, Powell, Nestor, Juan, Kris, and Baracas) make it out before the church collapses, and take the sick ones off to the hospital for treatment.

star 7.10
30 votes
Writers: David Ehrman, Mark Dodson
You're Not Alone

#13 - You're Not Alone

Season 1 - Episode 1 - Aired Sep 9, 2004

When people in New York City start turning the color blue, the NIH team is called upon to help cure this outbreak. When searching for the cause, a diner holds an important clue.

star 7.10
114 votes
Writers: Jason Horwitch, Michelle Ashford

#14 - Survivor

Season 1 - Episode 16 - Aired Feb 11, 2005

Split cases find Connor, Natalie, and Powell in New York City trying to cure victims who are presenting paralysis as a result of the September 11 Terrorist Attacks, and Miles and Eva down south trying to figure out what is causing the pregnant wives of military men to miscarry.

star 7.09
87 votes
Writers: Ayanna Floyd
Mission La Roca (1)

#15 - Mission La Roca (1)

Season 1 - Episode 19 - Aired Mar 18, 2005

Connor and Powell must travel to a small Mexican town after an earthquake strikes, trapping Natalie, Eva, and Miles. Only when they go after Miles, who was trapped in the church Mission La Roca, they are captured by insurgents.

star 7.07
55 votes
Directors: Karen Gaviola
Writers: Craig Van Sickle, Steven Long Mitchell
Ice Station

#16 - Ice Station

Season 1 - Episode 14 - Aired Jan 28, 2005

The team is trapped in a snowstorm in the arctic while trying to figure what is causing pneumonia in patients that also causes psychosis. To make matters worse, one of their own goes down with the same illness.

star 7.07
58 votes
Writers: Mark Dodson

#17 - Mousetrap

Season 1 - Episode 15 - Aired Feb 4, 2005

The team travels to Baltimore to help stop an outbreak of the plague, a disease that wiped out much of Europe in the middle ages. But they uncover a string of dirty cops, who were trying to cover up a murder, in the process.

star 7.05
58 votes
Directors: Norberto Barba
Writers: Barry M. Schkolnick, Craig Van Sickle, Steven Long Mitchell

#18 - Tribe

Season 1 - Episode 13 - Aired Jan 14, 2005

A smallpox outbreak sends the NIH team to Montana. However, is this once thought to have been eradicated disease caused by terrorism, or is it natural?

star 7.02
58 votes
Directors: Marc Buckland
Writers: David Graziano, Jason Horwitch

#19 - Escape

Season 1 - Episode 4 - Aired Sep 24, 2004

When the vacationers in a Bahama resort start falling ill, the NIH team is called in to discover the cause of this devastating illness. The only problem is that this disease is not effecting the children. However, when the first child falls ill with the same symptoms, the common link is found, and an illegal drug holds a clue.

star 6.89
114 votes
Directors: Marc Buckland
Writers: Daniel Arkin

#20 - Team

Season 1 - Episode 6 - Aired Oct 15, 2004

When the jocks of a Midwestern College start falling prey to a crippling disease, the NIH team is summoned to investigate. At first, the suspected agent is Multiple Sclerosis. However, when the coach, as well as some sorority pledges fall ill with similar symptoms, the NIH team is baffled. As it turns out, the girls are not suffering from the same illness. The common links are discovered, and for the jocks, an athletic banquet holds the answer, and for the pledges, a tube of foreign lipstick holds the answer.

star 6.67
60 votes
Directors: Guy Ferland
Writers: Laurence Andries