The BEST episodes of Grey's Anatomy season 4

Every episode of Grey's Anatomy season 4, ranked from best to worst by thousands of votes from fans of the show. The best episodes of Grey's Anatomy season 4!

A drama centered on the personal and professional lives of five surgical interns and their supervisors.

Last Updated: 12/14/2024Network: ABC (US)Status: Continuing
Freedom (2)
star
8.03
1226 votes

#1 - Freedom (2)

Season 4 - Episode 17 - Aired 5/22/2008

Meredith and Derek get one last shot at success in their clinical trial; the surgeons work together to free a boy from a block of cement; Izzie helps Alex care for Rebecca; Lexie uncovers critical information about George's status as an intern.

Directors: Rob Corn
Watch Now:AmazonApple TV
Crash into Me (2)
star
7.81
1440 votes

#2 - Crash into Me (2)

Season 4 - Episode 10 - Aired 12/6/2007

Meredith works furiously to save a paramedic trapped in an ambulance; Lexie holds the life of a patient in her hands; Derek must rely on a nurse to save a patient; Bailey struggles to balance her personal life with her work.

Directors: Jessica Yu
Watch Now:AmazonApple TV
Freedom (1)
star
7.75
1464 votes

#3 - Freedom (1)

Season 4 - Episode 16 - Aired 5/22/2008

A couple undergoes surgery. Derek and Meredith's clinical trial gets a second shot from a new patient. Izzie helps Alex. McSteamy hooks up with someone.

Directors: Rob Corn
Watch Now:AmazonApple TV
Crash into Me (1)
star
7.74
1476 votes

#4 - Crash into Me (1)

Season 4 - Episode 9 - Aired 11/22/2007

An ambulance crash endangers the lives of the paramedics involved, as Meredith and the Chief work on-site to save them, Bailey treats a patient who refuses her help, and Ava returns for Alex and meets his other girlfriend in the process.

Directors: Michael Grossman
Watch Now:AmazonApple TV
Let the Truth Sting
star
7.58
1470 votes

#5 - Let the Truth Sting

Season 4 - Episode 3 - Aired 10/11/2007

The doctors meet the world's oldest intern. Marcy brings in her son Henry because she finds his change in behavior suspicious. A patient named Connie may lose her vocal chords unless Mark and Richard can perform a radical new surgery. George impresses the other interns at work but at home he is trying to deal with his guilt about having sex with Izzie.

Directors: Dan Minahan
Writer: Mark Wilding
Watch Now:Apple TV
Forever Young
star
7.56
1393 votes

#6 - Forever Young

Season 4 - Episode 8 - Aired 11/15/2007

There has been a bus crash and the patients are in the ER. Meredith and Derek's relationship gets more complicated when he dates a fellow doctor. Meredith's dad goes to visit her at the hospital.

Directors: Rob Corn
Writer: Mark Wilding
Watch Now:Apple TV
Haunt You Every Day
star
7.52
1498 votes

#7 - Haunt You Every Day

Season 4 - Episode 5 - Aired 10/25/2007

It's Halloween at Seattle Grace! There may be jokes, pranks, and/or scare tactics. Some of the women form a club based on an experience they all share. A man volunteers for what most of the doctors believe is an unnecessary surgery. One of the patients is in the hospital because they tried to carve a pumpkin in an unconventional manner.

Directors: Bethany Rooney
Watch Now:Apple TV
The Heart of the Matter
star
7.49
1541 votes

#8 - The Heart of the Matter

Season 4 - Episode 4 - Aired 10/18/2007

A face familiar to one of the year-twos shows up and dredges up issues that were never really dealt with. A teen soccer player needs counseling because of his father and surgery for an injury he sustained while playing the game. Another patient's, named Courtney, finds out that her cancer is back.

Directors: Randy Zisk
Watch Now:Apple TV
Piece of My Heart
star
7.47
1500 votes

#9 - Piece of My Heart

Season 4 - Episode 13 - Aired 5/1/2008

Addison visits Seattle Grace because they need skills that only she has. Rebecca/Ava returns with news for Alex. Meredith and Derek's clinical trial experiences one or two developments.

Directors: Mark Tinker
Writer: Stacy McKee
Watch Now:Apple TV
Losing My Mind
star
7.46
1271 votes

#10 - Losing My Mind

Season 4 - Episode 15 - Aired 5/15/2008

Dr. Wyatt refuses to let Meredith give up on therapy. Alex learns something else about Rebecca. The Chief wants Erica to perform a daring surgery. Christina continues to act strange.

Directors: James Frawley
Writer: Debora Cahn
Watch Now:Apple TV
The Becoming
star
7.45
1462 votes

#11 - The Becoming

Season 4 - Episode 14 - Aired 5/8/2008

The clinical trial continues to make progress. The anti-McSteamy club creates new initiatives but that isn't enough to stop one woman from spending time with him. Christina is affected by Burke's career developments.

Watch Now:Apple TV
A Change Is Gonna Come
star
7.45
1607 votes

#12 - A Change Is Gonna Come

Season 4 - Episode 1 - Aired 9/27/2007

Entering their first year as residents, Meredith Grey, Cristina Yang, Izzie Stevens and Alex Karev now have interns of their own to mentor. Among the new interns are George, forced to repeat his internship after failing his exams, and Lexie Grey, Meredith's half-sister. Another two new interns will be introduced in this season premiere. And they'll have their hands full when a three-car accident sends multiple casualties pouring into Seattle Grace. Some of the doctors need to deal with new stressed out interns. A young boy brings his bleeding deer to the hospital in the hope a doctor will save her.

Directors: Rob Corn
Watch Now:Apple TV
Physical Attraction… Chemical Reaction
star
7.45
1436 votes

#13 - Physical Attraction… Chemical Reaction

Season 4 - Episode 7 - Aired 11/8/2007

Two arguing parents, who are named Jane and Don, bring their son in because he swallowed coins, while a middle aged woman comes in wanting cosmetic surgery on her chin. A father worries about raising a child alone when the mother needs surgery.

Directors: Jeff Melman
Watch Now:Apple TV
Kung Fu Fighting
star
7.44
1592 votes

#14 - Kung Fu Fighting

Season 4 - Episode 6 - Aired 11/1/2007

A patient comes to the ER with a dream and a condition which may prevent him from realizing it. Two patients are competing to win something big. One of them convinces an intern to take their place.

Directors: Tom Verica
Writer: Stacy McKee
Watch Now:Apple TV
Love/Addiction
star
7.43
1398 votes

#15 - Love/Addiction

Season 4 - Episode 2 - Aired 10/4/2007

A patient is in the hospital because they fell asleep in a hazardous situation. A patient's home laboratory blew up in an apartment building and the victims flood the hospital. Alex investigates the cause of the incident by talking to a really old guy who lived in the building. Jane Burke shows up to deal with what her son left behind. Lexie tries to talk to Meredith. Callie is overwhelmed by her new position while Bailey is searching for things to do.

Directors: James Frawley
Watch Now:Apple TV
Lay Your Hands on Me
star
7.43
1518 votes

#16 - Lay Your Hands on Me

Season 4 - Episode 11 - Aired 1/10/2008

George has a surprise visitor. Bailey's family is falling apart. Derek sorts through what kissing Rose means. Meredith discovers something that doesn't inspire hope or happiness in her. Alex treats a faith healer.

Directors: John Terlesky
Watch Now:Apple TV
Where the Wild Things Are
star
7.29
1398 votes

#17 - Where the Wild Things Are

Season 4 - Episode 12 - Aired 4/24/2008

Time has passed but not much has changed. Sexual angst still runs rampant in the halls of Seattle Grace. Derek and Rose have been dating and Meredith has noticed the activities of her current off-again ex-boyfriend. The doctor's are in the midst of a competition.

Directors: Rob Corn
Writer: Zoanne Clack
Watch Now:Apple TV