The BEST episodes of Grey's Anatomy season 2

Every episode of Grey's Anatomy season 2, ranked from best to worst by thousands of votes from fans of the show. The best episodes of Grey's Anatomy season 2!

A drama centered on the personal and professional lives of five surgical interns and their supervisors.

Last Updated: 12/14/2024Network: ABC (US)Status: Continuing
Losing My Religion
star
8.27
1320 votes

#1 - Losing My Religion

Season 2 - Episode 27 - Aired 5/15/2006

This episode is the second part of a two-hour season finale. Richard tries to get information from Addison about a family member's condition. Callie and George have a talk about his feelings. Meredith and Derek have a talk about Doc.

Directors: Mark Tinker
Watch Now:AmazonApple TV
It's the End of the World
star
8.11
1627 votes

#2 - It's the End of the World

Season 2 - Episode 16 - Aired 2/5/2006

An explosive case arrives at the O.R. that might endanger all the lives of the people working there, which leads Dr. Burke to declare a "Code Black" for the hospital. Bailey worries where her husband is as she is in labor. Also Izzie and Alex may be creating some heat.

Directors: Peter Horton
Watch Now:AmazonApple TV
As We Know It
star
8.04
1468 votes

#3 - As We Know It

Season 2 - Episode 17 - Aired 2/12/2006

Derek is still operating when he finds out about Meredith's current situation. Meredith is freaking out about her situation. Webber and Bailey are dealing with medical health issues. Cristina and Izzie have their own issues to deal with because of Meredith's situation. Addison freaks out when George tries to find a solution to Bailey's impromtu postponement. Overall, Seattle Grace Hospital is still under code black and the situation is getting worse.

Directors: Peter Horton
Watch Now:AmazonApple TV
17 Seconds
star
7.91
1472 votes

#4 - 17 Seconds

Season 2 - Episode 25 - Aired 5/14/2006

George and Derek work together, Denny still doesn't have a heart, and Meredith gets paired with Callie. A 12-week pregnant girl dies in the O.R. and her parents try to keep the baby alive. This causes tension between Derek and Addison. One doctor's overreaction unites two bickering patients. Finn is still treating Doc for medical problems.

Directors: Dan Minahan
Writer: Mark Wilding
Watch Now:AmazonApple TV
Into You Like a Train
star
7.83
1587 votes

#5 - Into You Like a Train

Season 2 - Episode 6 - Aired 10/30/2005

Train Wreck victims come to Seattle Grace and all staff gets called in. Everyone deals with really weird cases. Except Addison and Izzie. They work with a woman who is pregnant.

Directors: Jeff Melman
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Deterioration of the Fight-or-Flight Response
star
7.80
1388 votes

#6 - Deterioration of the Fight-or-Flight Response

Season 2 - Episode 26 - Aired 5/15/2006

Denny needs a heart or else. Izzie and George go crazy trying to get him one. Derek has the life of a friend in his hands as he operates on Burke who has been shot. Burke cannot operate on Denny after Denny's heart stopped and now Denny is in a dire condition. Cristina gets put in charge of the ER and she is worried about Burke.

Directors: Rob Corn
Watch Now:AmazonApple TV
Raindrops Keep Falling on My Head
star
7.78
1791 votes

#7 - Raindrops Keep Falling on My Head

Season 2 - Episode 1 - Aired 9/25/2005

Picks up where the last episode left off. Meredith attempts to work with Addison Shepard. George is pimped out to relay the hospital gossip back to Webber. Meredith and Cristina relate at Emerald City Bar about what dating their respective attendings is like. Cristina ponders her relationship with Burke while trying to make a decision. Meredith is devastated by the latest blow to her love life. Meanwhile, Joe the bartender collapses.

Directors: Peter Horton
Writer: Stacy McKee
Watch Now:AmazonApple TV
Damage Case
star
7.73
1365 votes

#8 - Damage Case

Season 2 - Episode 24 - Aired 5/7/2006

The staff attends to an intern from another hospital who has short-term memory loss. This intern, named Marshall, also has caused a car accident that involved a married couple, their unborn baby and the woman's parents who the staff are also treating. The pregnant woman is named Melanie and she will die but her baby may survive. One of the female interns meets up with a woman from her past who is planning on having a family of her own. Cristina is in a good mood although Alex, Izzie, George, and Meredith are having problems but in the meantime Burke hasn't forgiven Cristina for her late night faux pas. Meredith and Izzie are making fun of Callie's household habits and George and Callie are having a fight because of George's roommates. Addison is continuing to own Alex and he's upset about it. Denny has an outburst at Izzie and Derek has an outburst at Meredith.

Directors: Tony Goldwyn
Writer: Mimi Schmir
Watch Now:AmazonApple TV
Make Me Lose Control
star
7.73
1650 votes

#9 - Make Me Lose Control

Season 2 - Episode 3 - Aired 10/9/2005

Cristina and Meredith try to figure out if Cristina should tell Burke that she's pregnant right before Cristina faces an emergency. Alex and Izzie get closer while Meredith's mother gets too close.

Directors: Adam Davidson
Watch Now:AmazonApple TV
Enough Is Enough (No More Tears)
star
7.68
1506 votes

#10 - Enough Is Enough (No More Tears)

Season 2 - Episode 2 - Aired 10/2/2005

There's tension between Meredith and Addison. We find out why Derek and Addison aren't together. Bailey puts George on an impossible case. The rest of the interns operate on a family that was just in a car accident.

Directors: Peter Horton
Watch Now:Apple TV
Owner of a Lonely Heart
star
7.67
1433 votes

#11 - Owner of a Lonely Heart

Season 2 - Episode 11 - Aired 12/4/2005

Cristina Yang has little sympathy for Constance Ferguson (special guest star Rosanna Arquette), a prison inmate who jeopardizes her health just to get out of solitary confinement. Meanwhile the interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges, Izzie's anger at Alex reaches boiling point, and Dr. Addison Shepherd decides to teach Izzie a very painful lesson.

Directors: Daniel Minahan
Writer: Mark Wilding
Watch Now:Apple TV
Yesterday
star
7.65
1496 votes

#12 - Yesterday

Season 2 - Episode 18 - Aired 2/19/2006

Derek and Addison's relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of the staff. Burke and Cristina's relationship is affected when one of her secrets is outted. Alex and Izzie are having similar reactions to their closet scenes during the Code Black crisis. On top of this a cocky doctor shows up to piss Derek off in all kinds of ways. A patient is suffering from constant orgasms and her condition sparks interesting conversations among the staff. George is trying to figure out how to get Meredith to see him as more than just a housemate. Another patient, that Derek is treating, is dealing with a rare disorder and needs his parents support and understanding. Burke has a patient who inspires him to talk to Meredith and Cristina about doing what they say they will. Meanwhile, Meredith learns more about her family (in fact maybe more than she may have wanted to know) through her parents.

Directors: Rob Corn
Watch Now:Apple TV
What Have I Done to Deserve This?
star
7.65
1452 votes

#13 - What Have I Done to Deserve This?

Season 2 - Episode 19 - Aired 2/26/2006

Meredith and George are experiencing morning-after tension at home and at work and it has the rest of the doctors wondering what's up. Derek and Addison are experiencing their own version of morning-after tension as a result of Mark's visit to Seattle. Bailey, returning the favor that was done for her during the Code Black situation, must treat Addison for a specific feminine problem. Izzie and Alex are making headway in their relationship until Denny Duquette comes back. Soon Alex is not-so-oddly jealous of the attention Izzie is showing to Denny. Someone finds comfort in confiding in a patient who is going through an ordeal of his own. Burke deals with a patient and gets to observe the patient's unstable relationship with his fiancée.

Directors: Wendey Stanzler
Writer: Stacy McKee
Watch Now:Apple TV
Grandma Got Run Over by a Reindeer
star
7.63
1517 votes

#14 - Grandma Got Run Over by a Reindeer

Season 2 - Episode 12 - Aired 12/11/2005

The holiday season has started but not everyone is in a festive mood. This is Alex's last day in the hospital unless he passes his boards practical exam the next day, thus everyone helps him to review so that he succeeds. However, Izzie is not happy about the others helping him and Meredith has to remind her of the true spirit of the Christmas holiday. Justin is in need of a new heart. One is available but he does not want it because he does not believe Santa gave it to him as his mother said. Cristina and Burke, both handling Justin's case, have opposing views on the matter due to their different stances on religion. Despite a reconciliation with his wife, Derek isn't in a festive mood. George has a simple case of a woman who has a bleeding ulcer, he realizes that the ulcer is caused by her entourage but fails to keep them away, with the consequence that it perforates.

Directors: Peter Horton
Watch Now:Apple TV
Bring the Pain
star
7.62
1604 votes

#15 - Bring the Pain

Season 2 - Episode 5 - Aired 10/23/2005

Cristina goes right back to working right after being discharged. Izzie isn't talking to Alex. Derek and Meredith treat a patient. George and Alex get stuck in an elevator.

Directors: Mark Tinker
Watch Now:Apple TV
Something to Talk About
star
7.59
1540 votes

#16 - Something to Talk About

Season 2 - Episode 7 - Aired 11/6/2005

Cristina, Izzie and Meredith take care of Shane, a man who appears to be crazy and claims that he is pregnant. Shane's case induces a spreading fascination among the staff. George relates to a patient's husband.

Directors: Adam Davidson
Writer: Stacy McKee
Watch Now:Apple TV
Break on Through
star
7.59
1482 votes

#17 - Break on Through

Season 2 - Episode 15 - Aired 1/29/2006

All the nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves. George refuses to cross the picket line and finally joins the nurses on their strike while Alex, Cristina, Izzie and Meredith meets Bailey's stand-in: Dr. Cindy Aaron, the complete opposite of Miranda Bailey. Izzie agrees to work on a difficult pregnancy case with Addison, while Cristina and Alex are in the pit attending to a young married woman with a real bad case of rash. Meredith happens on an old woman that she needs to intubate and then learns she was DNR.

Directors: David Paymer
Writer: Zoanne Clack
Watch Now:Apple TV
Deny, Deny, Deny
star
7.59
1628 votes

#18 - Deny, Deny, Deny

Season 2 - Episode 4 - Aired 10/16/2005

As Cristina tries to recover, she proves to be a very difficult patient, and a visit from her mother doesn’t improve her demeanor any. And Meredith’s mother, Dr. Ellis Grey, has the hospital staff running in circles.

Directors: Wendey Stanzler
Writer: Zoanne Clack
Watch Now:Apple TV
Let It Be
star
7.58
1528 votes

#19 - Let It Be

Season 2 - Episode 8 - Aired 11/13/2005

Meredith tries to avoid the Shepherds. Cristina and Burke go out on a date and end up getting caught up in their jobs. Derek asks Meredith not to ignore him until Addison comes walking around the corner.

Writer: Mimi Schmir
Watch Now:Apple TV
Much Too Much
star
7.57
1533 votes

#20 - Much Too Much

Season 2 - Episode 10 - Aired 11/27/2005

Dorie Russell is waiting for quintuplets, all 5 girls. Her husband seems more concerned than she is but she is set to bring her babies to their term of 36 weeks. All the departments are on call for the quintuplets as three of them have developped problems of different kinds. Meredith last night's stand shows up at the hospital with priapism and they need to call Derek Sheperd for a consult which puts Meredith in a very embarassing position. Alex and Derek must take care of a patient who has a tumor inducing thirst as a side effect. On the love side, Alex and Izzie are having some slight sexual problems, while Meredith goes on adding one night stands and Cristina is thrown off course by being "keyed."

Directors: Wendey Stanzler
Watch Now:Apple TV
Band-Aid Covers the Bullet Hole
star
7.57
1462 votes

#21 - Band-Aid Covers the Bullet Hole

Season 2 - Episode 20 - Aired 3/12/2006

The doctors are up to their necks in their usual levels of drama. Meredith is dealing with the backlash of sleeping with George, George and Burke are bonding in ways that bother and creep out Cristina, Cristina gets stuck on diaper duty, Bailey gets involved in a case even though she's still supposed to be on maternity leave, Addison and Derek have a talk, and Izzie is still flaking on Alex for Denny Duquette, the heart patient who didn't get a heart. In the patients-of-the-week department we've got a very pregnant woman, a hockey player who desires medically unnessasary amputation, and a woman with a fork in her neck who happens to be dying and has a struggling marriage.

Watch Now:Apple TV
Thanks for the Memories
star
7.56
1582 votes

#22 - Thanks for the Memories

Season 2 - Episode 9 - Aired 11/20/2005

It's Thanksgiving at Seattle Grace Hospital but the holiday's festivites are less than in order. Meredith and Derek try to counsel a family after their relative has had a seriously traumatic accident.

Directors: Michael Dinner
Watch Now:Apple TV
Blues for Sister Someone
star
7.54
1348 votes

#23 - Blues for Sister Someone

Season 2 - Episode 23 - Aired 4/30/2006

Addison's patient is a Catholic mother of seven. Addison gets in trouble after learning that the patient's husband won't use contraceptives. Derek treats a divorce attorney who asks if Derek is in need of her services. While Izzie and George are talking about their personal lives they "overhear" part of Derek's conversation with the divorce attorney who calls herself one of Seattle's best. Alex gets in trouble with Addison yet again for not being able to keep his mouth shut when other people think he should. A legendary jazz musician refuses to see medical reason. The musician is Burke's musical hero. Finn makes Meredith breakfast.

Directors: Jeff Melman
Watch Now:Apple TV
Superstition
star
7.52
1390 votes

#24 - Superstition

Season 2 - Episode 21 - Aired 3/19/2006

After a series of deaths at the hospital some of the staff become very superstitious. Izzie worries about Denny and gets confronted by Alex. A patient with OCD drives Cristina crazy. Derek and Addison discuss their relationships with Meredith. Richard treats a friend from 17 years ago who reveals a secret about a dark time in his past that involves Ellis. George gets an earful about the women he's not talking to. Burke and Cristina argue about kicking George out.

Directors: Tricia Brock
Watch Now:Apple TV
The Name of the Game
star
7.52
1433 votes

#25 - The Name of the Game

Season 2 - Episode 22 - Aired 4/2/2006

Meredith and Izzie take up knitting. Derek operates on Andrew, a spelling bee champ with a serious head injury. Bailey gets in on Andrew's surgery because she's worried that her coworkers won't recognize her Nazi-status now that she's a mother. Addison's patient has an unborn baby with medical issues. After Alex fails to bite his tongue when a terminal patient routinely lies to her daughter about her health he gets a lesson in bedside manners from Burke. George also begins to overstay his welcome at Burke's apartment after Callie visits him. Meredith has more confusing and uncomfortable encounters with members of her family. One of the female doctors meets a veterinarian named Finn. Izzie flirts with Denny and they play more naughty-Scrabble. Meredith, Derek, and Addison sarcastically take another small stab at their friendships.

Directors: Seith Mann
Writer: Blythe Robe
Watch Now:Apple TV