Four egocentric friends who run a neighborhood Irish pub in Philadelphia try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.
The gang fudge history by claiming that Paddy's Pub was responsible for cracking the Liberty Bell in an attempt to turn their dive into a Philadelphia landmark.
When Frank's long lost brother Gino shows up at the bar, the two of them tell the gang about the jazz club they ran in the 1960s and 70s, and how they fell out over Shadynasty, a singer who was the love of both of their lives.
Upon discovering that their self-made “Lethal Weapon” sequels have been pulled from the local library, the Gang decides to address their political incorrectness by making another film: “Lethal Weapon 7.”
Annoyed that the Gang failed to react as he nearly choked to death on an appetizer, Frank decides the Waiter, his savior, is the only person who has his back.
Dennis and Charlie stand guard at the entrance to their laser tag base waiting to ambush the legendary "Big Mo," but Dennis begins to ponder the reasons they play laser tag and if their pursuit of a victory is worth their effort.
Guided by a young priest, Mac spends a day at the seminary to truly understand what it takes to become a priest. Dennis and Frank plan an elaborate trap at the castle to humiliate Charlie’s pen pal. Dee prepares for a date with an Irish doctor, only to find herself sinking in a bog. Having learned of his pen pal’s true identity, Charlie bonds with him and makes a choice that will forever change the Gang.
The gang have a new scheme and Frank tries to keep up.
The guys hire Dee's friend, Terrell to promote the bar. Meanwhile, Charlie tries to prove that he is not a racist.
Mac and Dee become uncomfortable when the rest of the guys decide to make some extra money by exploiting the similarities between a water stain and the Virgin Mary. A reunion with someone from the past, stirs up forbidden feelings within Dee.
The guys buy a gun after the bar's safe is stolen.
Dennis makes a movie spotlighting his erotic memoirs while Frank and Mac try to pass off Charlie as a gifted artist to make money.
As a record-breaking heat wave overtakes Philly, the Gang plans to profit from global warming by pumping up the A/C so people will congregate at Paddy’s and save energy at home.
The Gang looks back on 2020 to justify their numerous PPP loans. In doing so, it is revealed that they contributed to the chaos of the past political year way more than anyone could have imagined.
When a trendy new hair salon opens up right next door to Paddy’s, Dennis and Frank go on the offensive to stop women from cutting off their hair. Meanwhile, Mac is reunited with his childhood dog Poppins.
A girl from Charlie's past reveals they have a child together. Mac sees the benefits in being a pro-life advocate, while Dennis uses an abortion rally to meet women.
Dennis and Mac make a decision to take away all rules concerning moral and behavioral etiquette at Paddy's after an argument about the Constitution. Frank uses the decision and it's following consequences to his own gain. Meanwhile, Charlie tries to convey his love for America by protesting while Dee attempts to reaffirm her goal of being an actress.
After discovering that he might have cancer, Mac and Dennis attempt to find a woman who will sleep with Charlie. In the midst of their search, Mac falls in love with a transsexual he meets at the bar named Carmen. Overwhelmed by the extra workload that she had to take on since Charlie has taken a leave of absence, Dee tries to get Dennis to hire a recently out of work actress friend to help out.
Charlie and Mac's old high school gym teacher is accused of molestation.
After reminiscing about high school, the guys conclude that it would be a public service if they allowed teens to drink in the bar, thus providing a safe and controlled environment for teens to party. Feeling that she missed out on a lot as a teenager due to having to wear a brace for her scoliosis, Dee begins dating a high school jock.
Driven by Frank's insight into the world of politics, Dennis pursues a political career by running for office.
The guys are in the final preparation stage for an unknown scheme when Dee enters to inform them that it is "Dee Day," and they have to do everything she wants without complaint.
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