The BEST episodes of Grey's Anatomy season 22

Every episode of Grey's Anatomy season 22, ranked from best to worst by thousands of votes from fans of the show. The best episodes of Grey's Anatomy season 22!

A drama centered on the personal and professional lives of five surgical interns and their supervisors.

Last Updated: 11/2/2025Network: ABC (US)Status: Continuing
Only the Strong Survive
star
7.56
189 votes

#1 - Only the Strong Survive

Season 22 - Episode 1 - Aired 10/9/2025

After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.

Directors: Debbie Allen
Writer: Meg Marinis
Between Two Lungs
star
7.49
147 votes

#2 - Between Two Lungs

Season 22 - Episode 3 - Aired 10/23/2025

A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance, Lucas' war with Wes begins to impact his decision making, Teddy takes her mind off things by assisting Jo with car sale negotiations, and Kwan gets off to a rocky start with new plastics fellow Dr. Mohanty.

Directors: Debbie Allen
We Built This City
star
7.46
162 votes

#3 - We Built This City

Season 22 - Episode 2 - Aired 10/16/2025

A tragic death rocks the team at Grey Sloan in more ways than one as they navigate a chaotic first day of surgical rotations amid hospital renovations and memorials. Meanwhile, Meredith spends time with Amelia.

Directors: Kevin McKidd
Writer: Zoanne Clack
Goodbye Horses
star
7.41
82 votes

#4 - Goodbye Horses

Season 22 - Episode 4 - Aired 10/30/2025

The interns juggle a bizarre trauma, Teddy begins to appreciate her circumstances, while a complex breast reconstruction forces Meredith into a tense partnership.