The BEST episodes of Grey's Anatomy season 22
Every episode of Grey's Anatomy season 22, ranked from best to worst by thousands of votes from fans of the show. The best episodes of Grey's Anatomy season 22!
A drama centered on the personal and professional lives of five surgical interns and their supervisors.

#1 - Only the Strong Survive
Season 22 - Episode 1 - Aired 10/9/2025
After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.

#2 - Between Two Lungs
Season 22 - Episode 3 - Aired 10/23/2025
A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance, Lucas' war with Wes begins to impact his decision making, Teddy takes her mind off things by assisting Jo with car sale negotiations, and Kwan gets off to a rocky start with new plastics fellow Dr. Mohanty.

#3 - We Built This City
Season 22 - Episode 2 - Aired 10/16/2025
A tragic death rocks the team at Grey Sloan in more ways than one as they navigate a chaotic first day of surgical rotations amid hospital renovations and memorials. Meanwhile, Meredith spends time with Amelia.

#4 - Goodbye Horses
Season 22 - Episode 4 - Aired 10/30/2025
The interns juggle a bizarre trauma, Teddy begins to appreciate her circumstances, while a complex breast reconstruction forces Meredith into a tense partnership.