The BEST episodes of Grey's Anatomy season 21

Every episode of Grey's Anatomy season 21, ranked from best to worst by thousands of votes from fans of the show. The best episodes of Grey's Anatomy season 21!

A drama centered on the personal and professional lives of five surgical interns and their supervisors.

Last Updated: 4/23/2025Network: ABC (US)Status: Continuing
If Walls Could Talk
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#1 - If Walls Could Talk

Season 21 - Episode 1 - Aired 9/26/2024

After firing some of Grey Sloan’s best, Catherine continues to interfere with Meredith and Amelia’s research. Accidents at a climate change protest bring unique cases to the hospital, and Bailey encounters a blast from the past.

Directors: Debbie Allen
Writer: Meg Marinis
Watch Now:Apple TV
Take Me to Church
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#2 - Take Me to Church

Season 21 - Episode 2 - Aired 10/3/2024

Meredith and Catherine continue to disagree, and Meredith confides in Bailey for support. Richard, Winston and Lucas spend the day outside of the hospital, and Blue deals with a relationship from his past. Levi meets the new hospital chaplain.

Directors: Kevin McKidd
Watch Now:Apple TV
I Can See Clearly Now
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#3 - I Can See Clearly Now

Season 21 - Episode 3 - Aired 10/10/2024

Simone and Lucas work to balance their relationship while competing to assist on an awake kidney transplant. Teddy offers Amelia a new opportunity, and Ben’s interview doesn’t go as planned. Meredith’s secret causes tension with Richard.

Directors: Victoria Mahoney
Watch Now:Apple TV
This One's for the Girls
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#4 - This One's for the Girls

Season 21 - Episode 4 - Aired 10/17/2024

Mika struggles with a life-altering personal matter. Meanwhile, Bailey and Ben navigate their personal and professional roles, while Levi finds a connection in an unlikely place. Jo and Link get surprising news.

Directors: Debbie Allen
Watch Now:Apple TV
You Make My Heart Explode
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#5 - You Make My Heart Explode

Season 21 - Episode 5 - Aired 10/24/2024

During a high-stress day at Grey Sloan Memorial, the fates of a patient in critical condition and a helicopter-bound medical team hang in the balance. Beltran spearheads an initiative, Teddy and Owen work on their marriage, while Bailey, Blue and Link treat a hospital employee.

Directors: Vanessa Parise
Writer: Zoanne Clack
Watch Now:Apple TV
Night Moves
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#6 - Night Moves

Season 21 - Episode 6 - Aired 11/7/2024

Teddy and Owen plan a date night that gets derailed in more ways than one, while Jo struggles to do it all at home. Mika adds more to her plate to make up for taking time off to be with her sister, and Levi is faced with a monumental decision.

Directors: Bille Woodruff
Watch Now:Apple TV
If You Leave
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#7 - If You Leave

Season 21 - Episode 7 - Aired 11/14/2024

The doctors at Grey Sloan must put aside their emotions under intense circumstances. Levi asks James a shocking question that could impact their future.

Watch Now:Apple TV
Drop It Like It's Hot
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#8 - Drop It Like It's Hot

Season 21 - Episode 8 - Aired 11/21/2024

In the midst of a deadly heat wave, the team at Grey Sloan struggles to keep up with an overwhelming amount of patients. Amelia and Winston face a challenging surgery, while Jo and Lucas run an errand for the hospital that takes an unexpected turn.

Directors: Kevin McKidd
Watch Now:Apple TV
Hit the Floor
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#9 - Hit the Floor

Season 21 - Episode 9 - Aired 3/6/2025

The aftermath of the convenience store shooting brings chaos to Grey Sloan. Ben hits a wall with his new emergency preparedness plan. Romantic tensions surface for Owen, while Amelia and Winston disagree over the surgical plan for a young patient.

Directors: Linda Klein
Writer: Jamie Denbo
Watch Now:Apple TV
Jump (for My Love)
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#10 - Jump (for My Love)

Season 21 - Episode 10 - Aired 3/13/2025

Meredith and Nick return to Grey Sloan to treat a liver transplant patient. Meanwhile, Bailey hosts an intern retreat at her home, Catherine gets a blast from her past, and Winston and Ben aid an unexpected crash victim.

Directors: Jesse Williams
Writer: Julie Wong
Watch Now:Apple TV
I Still Haven't Found What I'm Looking For
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#11 - I Still Haven't Found What I'm Looking For

Season 21 - Episode 11 - Aired 3/20/2025

Following a difficult case, Grey Sloan faces the complexities of medical ethics. Meanwhile, Bailey continues to navigate her working relationship with Ben, while a group of college students on a scavenger hunt causes chaos around the hospital.

Writer: Carol Brown
Watch Now:Apple TV
Ridin' Solo
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#12 - Ridin' Solo

Season 21 - Episode 12 - Aired 3/27/2025

Meredith and Amelia prepare a funding proposal for their Alzheimer’s research. Meanwhile, Owen and Teddy’s marriage hits a breaking point, and Jules has an awkward encounter with Monica.

Directors: Kevin McKidd
Watch Now:Apple TV
Don't You (Forget About Me)
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#13 - Don't You (Forget About Me)

Season 21 - Episode 13 - Aired 4/3/2025

Amelia and Simone attempt to perform a high-stakes and groundbreaking brain surgery. Meanwhile, Teddy runs into Cass while at a medical conference with Bailey, and Jo struggles with her irritation toward Marcus.

Directors: Kim Raver
Watch Now:Apple TV
Love in the Ice Age
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#14 - Love in the Ice Age

Season 21 - Episode 14 - Aired 4/10/2025

Bailey welcomes a renowned surgeon, whom she greatly admires, to Grey Sloan to help on a challenging case. Meanwhile, Teddy, Owen, Jules and Ben team up to save the life of a patient who has been impaled by an ice pick.

Writer: Kingsley Ume
Watch Now:Apple TV
Bust Your Windows
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#15 - Bust Your Windows

Season 21 - Episode 15 - Aired 4/17/2025

A window washer’s platform crashes through a hospital window, testing the Grey Sloan team’s limits. Meanwhile, Blue and Simone clash over their living arrangements, and Lucas strives to impress Catherine while on her service.

Directors: Lisa Leone
Writer: Scott Brown
Watch Now:Apple TV