Law & Order: Criminal Intent takes viewers into the minds of its criminals while following the psychological approaches the Major Case Squad uses to solve the crimes.
Goren and Eames investigate the murder of a former nurse and discover a possible anthrax terrorist plot. The case takes a turn for the worse when Goren is blamed for driving a suspect to commit suicide. Now disgraced, Goren learns that a cunning adversary from his past may be involved.
Detectives Eames, Goren, Barek, and Logan must solve a case that involves a teenage girl missing in New York City. While Barek and Logan search around for another missing girl, Eames and Goren work to uncover a mystery with a judge and his son.
Logan and Barek investigate a series of home invasions that result in grisly murders and their search leads them to local foster mother Chesley Watkins who had a series of young men going in and out of her home throughout the years. One of the young men involved in the home invasions was one of her boys, and while trailing the young man, Logan shoots a suspect who was brandishing a weapon at himself and Barek. When the suspect turns out to be a cop, Logan finds himself in the hot seat, and Barek sticks up for her partner, knowing that the truth is on their side. The investigation leads to Watkins as a suspect, and Logan is forced to deal with memories from his own past as Watkins plays on the weaknesses she sees.
Logan and Wheeler investigate the death of a womanising doctor, which leads directly to his son's relationship with a teacher.
Bobby is visited by the past when he finds a picture at his mother's grave indicating an old nemesis has returned, and the case only gets more complex when his brother and a mentor reappear.
Goren and Eames find a scrapbook belonging to a serial killer on death row. It suggests that he may have had more victims than previously known.
Logan and Falacci investigate the execution-style murder of three young college freshmen.
When the body of former teen star Alvin Stevens is found buried in Potter's Field, Logan and Wheeler try to find out who would have motive to murder the young man that Wheeler's generation affectionately remembers as lovable geek Skater. Their investigation soon leads them to bootleg DVDs, the Albanian mob, and another child star who never moved on with his life.
The investigation into the murder of a crooked cop leads to a preening veterinarian and his friend, an obsessive doctor whose ex-girlfriends who have all been infected with a rare disease.
Goren and Eames investigate when a respected professional is found murdered in the East River, his death presumably connected to a series of gambling losses.
When the body of a bisexual young woman is found slain, Goren and Eames note the similarities between her death and a number of murders committed by a convicted serial killer, turning their attention to a human-behavior researcher.
The squad continues the investigation into the murder of a teenage girl visiting from Iowa. The detectives uncover the sordid family life of a local judge whose son is linked to the Iowa teenager and another victim. Goren and Logan discover that the judge is a formidable foe as they come under scrutiny.
A wine importer's death on the heels of an exclusive wine tasting is investigated. The detectives focus on the workings of a high-end auction house, while the man's wife and a grifter couple also become suspects.
The investigation into the death of a woman searching for the whereabouts of her late mother's antique ring leads Goren and Eames to a physician serial killer who has cleverly concealed the murder of over two hundred of his patients.
When a woman suing her brother over the disposition of their father's remains is found murdered, Goren and Eames discover a concealed parentage and a man willing to go to any extremes to ensure his legacy.
Ross, Goren and Eames are called in on Thanksgiving when Amanda Dockerty, the daughter of the first deputy commissioner of the NYPD, goes missing while on leave from the army. The investigation into her disappearance soon turns into a murder case when Amanda's body is found, but Goren's mind is anywhere but on his job as he struggles to deal with a personal crisis concerning his mother.
Goren and Eames investigate the death of Heidi Conington, a former ambassador's daughter, and then the similar murder of Jenna Shea not long after, interviewing her roommate Jo Gage. Jo's father turns out to be Goren's former mentor, Dr. Declan Gage, who tries to convince Goren that the killer is Sebastian, the one killer that he has never been able to capture or forget. Ross warns Goren that he doesn't want Gage, who betrayed his entire team in the original Sebastian investigation, anywhere near the case. When Eames is taken from her home, suspicion turns to Gage, especially after some of her belongings are found in his possession, but when Eames saves herself, she can't give the police any clues to her captor.
Detectives Goren and Eames come to believe a doctor conducted shameful experiments on the residents of a halfway house.
When the wealthy and matronly owner is found naked and murdered with injections of botox in the bathtub, detectives Goren and Eames focus on the victim's unstable adult daughter who resented her mother's meddling in her love life
Tracking a modern-day Bonnie and Clyde, Goren deduces that one of his suspects has an injured foot. It isn't long before Goren and Bishop realise that the pair, who have already killed nine people including two undercover cops, are not the typical Bonnie and Clyde -- the female partner is obviously the one in control.
Goren and Eames head to Vietnam to pick up Simon Henry Fife, who has recently confessed to the 1992 murder of ten-year-old actress Amberleigh Harner. Both Goren and Eames have trouble believing what Fife has to say, and it isn't long before Goren manages to find holes in Fife's story. Eames and Goren have twenty-four hours to look into the murder and turn their attention to the original investigation, contacting the original officer on the scene. Their investigation leads them to believe that the suspect may be much closer to home than anyone thought.
After Russ Corbett and his wife are found in a seedy hotel room, Russ dead of an overdose, Eames and Goren follow the trail of evidence to Bernard Fremont, a professional partier. With his beautiful blonde companions, Fremont insinuates himself into the lives of couples who don't know the city very well, then robs them blind. While investigating Fremont's past in Asia, Goren realises that he is the mastermind that turned Nicole Wallace into a murderer, and his most successful pupil.
When the murder of a city auditor and his family seems too perfect, Goren and Eames turn their attention towards law enforcement personnel after learning that the auditor was investigating a number of former cops upon suspicion of double-dipping.
Logan and Wheeler investigate when fireman Ian Duffy is stabbed twenty-two times before driving himself to the fire station and collapsing. When the investigation leads to questions concerning Duffy's sexual preference, Logan and Wheeler end up in the middle of a brawl with the other firemen that leads to an official investigation and a secret involving Duffy's wife, his friend Brendan Keele, and a crime that someone else confessed to years earlier.
Goren and Eames investigate the killing of a man who became famous for dodging a murder conviction because of a mishandled trial. The man spun his notoriety into a TV show but turned up dead on his birthday.
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