Sam, a former pitcher for the Boston Red Sox, owns and runs Cheers, a cozy bar in Boston. Somewhat snobby, beautiful and intelligent Diane -- forced to become a waitress when her fiance jilts her -- constantly bickers with Sam. Eventually, they fall in love. Several wacky characters make the bar their home-away-from-home, including sarcastic waitress Carla, beer-loving Norm and Boston letter carrier Cliff.
Sam commissions a portrait of Diane from an artist so obnoxious that he soon forbids Diane to continue posing for him, an order Diane won't accept.
An old friend of Coach has died and Coach decides to hold a memorial to him in the bar, inviting all their old friends. But then Coach discovers his late friend made a pass at his late wife.
Sam lets a dying man tend bar just for fun, but the man leaves the bar patrons $100,000 in a paper napkin will.
Sam commissions a portrait of Diane from an artist so obnoxious that he soon forbids Diane to continue posing for him, an order Diane won't accept.
The regulars push Norm into pursuing an attractive new client who seems to be interested in him.
Norm gets arrested when he finishes the route for an ill Cliff, but Cliff refuses to back up Norm's explanation to the authorities.
Sam and Diane go to work after Dick Cavett suggests that Sam's autobiography might sell and Norm confronts an old flame of Vera's who's interested in her again.
Frasier is devastated when he learns that his learned mentor has been dating Carla, who also has a little surprise of her own.
The gang at Cheers declares war when rival bar, Gary's Old Town Tavern, steals the trophy celebrating their one and only sporting victory in a bowling tournament.
Cliff's know-it-all attitude finally gets him into a fight with another patron.
Carla feels compelled to call in an exorcist when Eddie's ghost appears in the bar and Rebecca complains to a TV station about a defective hair removal system.
Sam regrets asking Norm to do his taxes when the out of work accountant comes up with a five figure refund.
Diane is at first incredulous then furious when it becomes apparent that Sam and her old school chum find each other very attractive.
Sam and Diane want to spend some time alone together, but the lonely Coach keeps joining them, not realising he is spoiling things for them. Rather than hurt his feelings by asking him not to bother them, Sam and Diane decide to set him up with a woman so they will be left in peace.
Sam and Rebecca let their imaginations run free during a weekend of baby-making and dream up different versions of their future progeny.
Diane, angry at the implication that she couldn't hold a job anywhere but Cheers, leaves for better position and Norm leaves Vera.
Not wanting to appear lonely and dateless whilst going to her ex-husband Nick's wedding ceremony to blonde bimbo Loretta, Carla asks Sam to accompany her.
The gang tries to bring Woody back to earth after a vacation in London with Kelly and her money.
Cliff meets the woman of his dreams at the bar on Halloween night but is afraid of meeting her when he's not in costume, and Sam and Diane have their first non-romantic outing together after the breakup.
After the sad passing away of Coach, Sam hires a new bartender in Woody Boyd, Coach's pen pal who has moved to Boston. Frasier arrives back from Europe with the news that Diane left him at the altar for six months of decadent living across Europe and is now seeking renewal in a Boston monastery.
Carla and Eddie plan to get married if they can get past superstition, Eddie's mother, Carla's children, and Rebecca's nerves as she waits for her boss to show up at the bar.
Carla's formidable mother demands on her deathbed that Carla name one of her children "Benito Mussolini."
Carla is reluctant to accept the crystal ball passed to her by the retiring psychic, Madame Lazora.
Carla's daughter insists on having her father walk her down the aisle, despite Carla's objections.