David Banner is a research scientist trying to find a way to tap into the hidden strength that all humans possess. Then, one night in his labratory, an experiment went wrong, causing him to be overexposed to gamma radiation. Now, whenever angered or distressed, the mild-mannered scientist finds himself transforming into a powerful seven-foot green creature known as The Incredible Hulk. The Hulk is guided by David's personality, dealing with whatever distresses David. But unfortunately, David has no control over the creature's actions. Nor can he remember what he had done during his Hulkish states. He travels around the country in search of a cure, while taking various odd jobs under different aliases.
David's attempt at a cure is hindered by the other man's exposure to radiation, which revives the murderous Hulk persona the man was cured of many years before. Now, David must produce enough antidote to cure both himself and the other man before more carnage occurs.
David discovers the legend of another Hulk, and investigates in the hope of creating a cure for himself.
David 'Benton' travels to Hawaii to meet Dr. Carolyn Fields (Mariette Hartley), a psychologist whose technique might help control the Hulk. However, Dr. Fields is in the terminal stages of a disease that the Hulk could help cure. With the pair working in close proximity, love begins to bloom with tragic results.
After a boxer named Rocky rescues David from muggers, Rocky gets David a job at his gym. David tries to help Rocky when he discovers that their boss is a drug dealer and using the unknowing Rocky to deliver the goods.
Prometheus Part 1 of 2. After being exposed to the radiation of a meteor that had just crashed to the Earth, David's transformation back from the Hulk stops midway, leaving him half-Hulk/half human.
Unbeknownst to David, the apartment he is renting in San Francisco's Chinatown neighborhood contains the gold that gangsters are seeking.
Thanks to look-alike criminal, David becomes a victim of mistaken identity, and is pursued by the police and a vindictive gang. An attempt to leave town is hindered by Jack McGee, who is shocked to discover that David Banner might still be alive!
Banner is working in a tavern on the docks in Galveston, Texas, where he befriends the owner, a Union President's widow, whose husband was killed under suspicious circumstances. The woman is being pestered by a shady businessman, running to become the new President, to endorse his election campaign and he is willing to go to any lengths necessary to win the election.
When David's picture is taken by a tabloid photographer, he must stop the photograph from being published.
David boards a flight to visit another doctor whom he thinks has information that might help him with his problem. But, when the pilot and stewardess drugs the rest of the crew in an attempt to bail out of the airplane with stolen property, David and a young boy named Kevin try to land the jetliner.
After being invited to a remote island, David becomes the quarry of a psychotic hunter.
David works as the assistant of a magician, only to get mixed up in a situation involving the magician's estranged daughter and an ex-girlfriend with a questionable fiance.
Prometheus Part 2 of 2. David's half-Hulk/half-human condition leads a military group called Prometheus to believe that he is an alien, so they capture him, and then send him to a lab for study.
David helps a pregnant woman, and on their way to the hospital, they discover a plot to steal babies for DNA experimentation.
In New Orleans, David works for a young physician who tries to convince everyone that a local witch doctor is a con artist.
David finds himself caught in a feud between a skydiver and the son of a crooked politician.
With David's help, a woman tries to reopen her wax museum, which was nearly destroyed by a fire. But the task isn't easy, in part because the woman has hallucinations that are brought on by a questionable drug that she is taking.
David is hired as a stage manager at a carnival, and learns that the sideshow's mind-reader has been blamed for a series of misfortunes.
While visiting his sister and father for Thanksgiving, David must help salvage the family farm from a plague and a crooked developer; in addition, he tries to resolve the bitterness between himself and his father, whom he blamed for his mother's death many years before.
A body-builder gets signed up in a body-building contest, only to be at odds with some questionable people who are involved in the competition.
Banner poses as a top doctor in physics to infiltrate a research complex, in order to access some gamma-ray equipment that may just be able to cure him of his green alter ego. He is about to start the attempt of reversing his condition when an earthquake strikes, blowing his cover, causing mass destruction and devastation, and setting off an impending core melt-down.
David is arrested for vagrancy, and is sent to a prison camp run by a cruel warden. But when the appearance of Jack McGee prevents David from exposing the conditions of the camp to the press, his fellow inmates turn against him.
David discovers a murder plot while working in a Time Square arcade, where the owner is being extorted to pay for protection.
To save the lives of a reformed gangster and a kidnapped boy, David turns to an alcoholic ex-policeman for help.
While working at a zoo, David finds a female scientist doing genetic research, which could help him stop his unwanted transformations into the Hulk.