David Banner is a research scientist trying to find a way to tap into the hidden strength that all humans possess. Then, one night in his labratory, an experiment went wrong, causing him to be overexposed to gamma radiation. Now, whenever angered or distressed, the mild-mannered scientist finds himself transforming into a powerful seven-foot green creature known as The Incredible Hulk. The Hulk is guided by David's personality, dealing with whatever distresses David. But unfortunately, David has no control over the creature's actions. Nor can he remember what he had done during his Hulkish states. He travels around the country in search of a cure, while taking various odd jobs under different aliases.
A 1940s-style detective can't explain why a corpse is found in his office; except that it may be related to an extortion plot, a mysterious gardener, and a green creature.
David travels to Baltimore where he befriends a midget wrestler who has a habit of telling tall tales. Unfortunately, one of those tales gets David in trouble with mobsters.
David is kidnapped by a trio of convicts who have escaped from a women's prison. The situation becomes even more complicated when one of the women goes into labor.
David survives an automobile accident, only to be paralyzed from the waist down. Therefore, he is told that he may never walk again.
An irate lumber baron becomes a threat to David's relationship with a young woman, and tries to force David out of town.
An inexperienced reporter is assigned to help Jack McGee with his pursuit of the Hulk; then, to McGee's dismay, she does a story about a shy man who claims to be the Hulk's alter-ego.
David becomes an arson suspect, and is drafted to help extinguish a forest fire.
David attempts to help free a woman and her infant son from a gang of thieves. But one of the thieves is not willing to let that happen.
David finds tranquility in the wilderness in Baja, Mexico. However, that is soon hindered by the arrival of a doctor running from a vengeful man whose daughter died under her care.
When artifacts are discovered on an indian reservation which indicate the existence of a Hulk-like being 30,000 years ago, David joins the expedition to find out if there is a link to his problem...or possibly a cure.
David is befriended by a motorcyclist, who inadvertently gets him mixed up in a gang-related conflict.
While working at a car wash in a black neighborhood, David befriends a co-worker who is being exploited by a drug lord.
A serial killer is stalking the college where David is working; then a misunderstanding leads to David's arrest. And while he figures out the real identity of the killer, the townspeople form a lynch mob.
David works at a hardware store in a resort town, where business is receding. But when an argument with the store's depressed, widowed owner, Harlan, brings on the Hulk's appearance, Harlan and his friend quickly see the possibilities of what the publicity could do for the town. So they set about re-creating their own "monster" to draw in the tourists. But the scheme ends up endangering Harlan's own young daughter.
David meets a vindictive "Bonnie and Clyde"-type couple who are blowing up gas stations. The stations they are targeting belong to a corporation responsible for the death of the young man's father.
When David is unable to collect the money he won in a lottery, he sends a friend to collect it for him. But unfortunately, without David's consent, the friend, who is a former con artist, decides to use the money in a scheme to hopefully earn a larger profit.
Unbeknownst to David, the car that he is renting happens to be filled with stolen money. To make matters worse, David ends up being pursued by the thugs who are trying to fetch the loot.
David is working as a gardener in a suburban school, where he befriends a boy whom he notices is covered in bruises. The school nurse informs David that it's not the first time it's happened, and he soon suspects that one of the boy's parents is abusing him. With no-one willing to listen or help, David sets about putting the situation right himself.
In a follow-up to "Another Path," David visits his friend Li Sung to hopefully find a cure to his transformations. But the old philosopher is now dying and looking for a successor in his practices; the candidate for his leadership is a student, a police officer coping with the recent murder of his father.
A new publisher takes over the National Register, and decides to rid the newspaper of any questionable stories. This new policy affects Jack McGee's search for the Hulk, so McGee is put under pressure to prove that the Hulk is real.
As a medic for a rodeo, David discovers that an aging cowboy has a serious health condition that could prove fatal; meanwhile, the cowboy's younger brother is mixed up with a gang of cattle thieves.
David believes a Chinese philosopher's nerve control techniques can help him control the Hulk.
While working in a disco club, David tries to help a teenaged alcoholic who is being exploited.
When David learns of a vitamin that supposedly calms wild horses, he gets a job at the San Remos horse track hoping it can help him too.
While working in a casino, David helps a Las Vegas reporter with a gambling scandal, only to discover that the reporter is Jack McGee's partner.