A raucous comedy set in Victorian London about four medical pioneers fighting to make a mark on the world.
When William’s childhood friend Mina puts pressure on William to marry her, he has a difficult moral decision to make.
William stages a mock trial to cure a deluded patient, while Robert looks to advance his reputation by securing the backing of a wealthy female patron.
Caroline arranges for herself and William to meet a charismatic hypnotist at a local curry house for a demonstration of his powers.
Robert has a problematic patient – the Bishop of Lambeth needs his appendix removed or he will die. But he won’t agree to pain relief or surgery.
Robert is a domineering, showman surgeon - a rock star of his age - who is almost as brilliant as he thinks he is. He can pack out an operating theatre and take off a leg in 92 seconds. But after a botched amputation, Robert is put under pressure by the royal physician, Dr Hendrick. So John, a drug-addled dentist who is trying to create the world's first anaesthetic, convinces Robert to use potentially lethal ether in a prestigious and pioneering operation.
Caroline bags an invitation to meet her hero, Charles Dickens. William finds himself in an awkward position when he exaggerates how much of a fan he is - he hasn't read a single page. An excruciating evening ensues when William escorts Caroline to a dinner party at Dickens's house.