The series depicts the tribulations of the title character Parker Lewis, a Santo Domingo High School student, for whom nothing is impossible. Parker often narrates in shows. Just like his best friends, Jerry Steiner and Mikey Randall and his girlfriend Annie Sloan, his prime concern is achieving and maintaining "coolness" during the turbulent years of puberty. However, their efforts are often thwarted by Parker's little sister, Shelly, and principal Grace Musso. Apart from various aspects of teenage life, embedded in a surreal, living-cartoon-like quality and the clever camera angles and filming techniques (dissolves from one scene to the next were done by ever larger pixels), an episode regularly contains more or less subtle references to movies, politics, and celebrities. The 3,100 students are called "Flamingos", after their football team.
Jerry gets move into the A.S.A.P. program which makes him a senior, when he gets a B+ on his first test he freaks out, drops out and starts laying bricks. Grace has a recurring dream about The Scarlet Letter.
Jerry gets Kubiac elected homecoming king as a joke, but Larry takes it seriously.
Parker and Mikey help Jerry overcome stage fright so he can win the district science fair.
At the mall, Parker searches for his elusive dream girl, Jerry searches for a job, and Musso tries to stop spending money.
Parker's first bad day of the year is the last day of the school year.
The buds try to break Jerry of his lack of self-confidence when he is without his coat.
While Annie is away, Parker and Mikey go on a double date with two girls that they meet.
The buds use the school's pirate radio station to unwittingly turn everyone against them.
Musso wants the buds to make a documentary about the school, but Parker has no time thanks to his new history teacher.
Parker's mother plays Cupid for Ms. Musso and her brother. Musso changes her approach and thinks she has a relationship that will last.
Larry is hired to prevent shoplifting at the Lewis's video store, but he scares away the customers.
Musso mellows as she approaches her 40th birthday, so Parker calls in Dr. Pankow to get the old Musso back.
Parker asks out a girl he met on a computer bulletin board, but considers backing out when she is less than he hoped for.
Nick is where Parker turns to for advice when Annie breaks his heart.
Shelly blackmails Parker into helping her find a date for a party.
Dr. Pankow returns to oust Musso, and Parker must save her.
A local business man sponsors a family build-a-better-toaster contest and Mikey can't participate because his mother doesn't have the time.
Parker pulls one too many scams, causing one of his favorite teachers to quit.
Larry wins a magazine sweepstakes and discovers friends he never had before.
Shelly joins the Dark Siders, whose initiation calls for her to be suspended from school.
Musso forces Parker to make a decision about his future. Kubiac runs from his booster shot. Shelly takes revenge on the cheerleaders.
Shelly tries everything to meet her favorite rock star.
Parker's dad protests the banning of a rock album by Dr. Pankow.
Parker's favorite teacher must leave teaching for a better paying job to support his family.
Mikey needs extra cash so he gets a job at the diner.