The series depicts the tribulations of the title character Parker Lewis, a Santo Domingo High School student, for whom nothing is impossible. Parker often narrates in shows. Just like his best friends, Jerry Steiner and Mikey Randall and his girlfriend Annie Sloan, his prime concern is achieving and maintaining "coolness" during the turbulent years of puberty. However, their efforts are often thwarted by Parker's little sister, Shelly, and principal Grace Musso. Apart from various aspects of teenage life, embedded in a surreal, living-cartoon-like quality and the clever camera angles and filming techniques (dissolves from one scene to the next were done by ever larger pixels), an episode regularly contains more or less subtle references to movies, politics, and celebrities. The 3,100 students are called "Flamingos", after their football team.
Much to Kohler's dismay, Grace gets married to a man with a six-figure salary; however the bridegroom drops dead soon afterward.
Shelly tries to get her first kiss, and she sets her eyes on Brad Penny. Parker tries to stop her from completing her mission.
Parker tries to get Musso her job back after he discovers the replacement is much worse than she was.
Mikey joins a biker club and finds out it is no "easy ride" when he gets arrested.
Santo Domingo's favorite alumnus returns to accept an award.
Parker is waiting for the right girl, Tracy Lee Summers, to ask him to the Girls Ask Guys Dance.
The buds search for Mikey's secret admirer named "Breathless" and Parker doesn't like the result.
Coach Kohler takes over the guy's hangout.
Frank helps Jerry with American history. In exchange, Parker tries to find a date for Frank.
Parker fixes up Dr. Pankow with Ms. Musso, but Dr. Pankow may be plotting against her.
When his wife takes a philosophy class, Parker's father questions the universal truth of their marriage.
Parker and the gang find out that the Atlas Diner is going to be torn down in order to provide a location for a new strip bar. A clip show featuring highlights from all three seasons ensues.
Mikey drops out of school to become a guitar hero.
Shelly snubs her long-time friend to join the Vogues, the Heathers-like clique.
Parker and Annie plan a quiet evening at home which is interrupted by most of their friends.
Kohler is interested in the mother of the boy that Kubiak is babysitting. Annie tries to fix them up.
Parker and Mikey both find the girl of their dreams-- the same girl.
Parker has a crush on one of his teachers. Jerry wants a part in the school's production of The Music Man.
Mikey lets his school work slide when he gets a chance to impress a record executive.
Parker's diary falls into the wrong hands and he is afraid of the possible consequences if it gets out.
While working together, Kubiak develops a crush on Annie.
When he has trouble reading her, Parker fears that Annie may want to break up with him and he seeks advice from his mother.