Hannibal Heyes and Kid Curry, two successful and popular outlaw cousins in the old West, decide it's time to go straight. The problem is that the governor just can't give them amnesty right away, they have to prove that they deserve it. And in the meantime they will still be wanted. Hunting them is everybody, from sheriffs to bounty hunters, to posses and ordinary people. Hannibal Heyes/Joshua Smith is the thinker, the poker player and the optimist, while Kid Curry/Thaddeus Jones is the quick-drawing worrier who sometimes is a bit slow. Together they are Smith and Jones... Other regular characters include "Big Mac" McCreedy, a wealthy ranch owner, who's feuding with his next door neighbour, senor Armendariz. Harry Briscoe is an agent with Bannerman detective agency, who's perhaps not the brightest man around. Clementine Hale is a woman with an enormous zest for life. She owns the only picture of Heyes and the Kid and often uses it to get them to get her out of trouble.
The passengers of a coach are taken hostage at Diablo Station by four cowboys. Not discussing their ultimate goal, they keep Heyes and the Kid and the others tied up, just waiting. Soon, the goal becomes very clear to Heyes. The leader wants to avenge his brother's death - upon sheriff Lom Trevors. Can Heyes and the Kid, or any of the other passengers warn Lom before he arrives?
The boys are hired by a ranch owner as trappers, but when they meet his wife, she recognizes the Kid. The ranch owner and his wife tries to act natural, and sends Heyes and the Kid out into the hills trapping. But they also send a professional hunter after them. Heyes and the Kid are attacked by the hunter, and Heyes is wounded. The Kid manages to out-maneuver the hunter by himself, and they tie him up, leaving him in the woods for the ranch owner to pick up. Before they leave, the hunter tells them that he was sent by the rancher. This makes Heyes and the Kid go visit the ranch, where they decide to take the rancher and his wife as human shields while they ride to the nearest rail road. But on the way there, they are ambushed and pinned down behind a rock in the middle of nowhere by the hunter and his sharpshooting rifle. It's only a matter of time before he shifts position and makes the kill...
With McCreedy's $5000 and ready to go to Santa Marta, the boys turn back to Texas, to get their friend Clementine. When they get there, they decide that it would arouse less suspicion if one of them were married. A game of poker seals the Kid's fate, but before they can leave, they are shot at. The house is surrounded by a group of men bent on taking Heyes and the Kid. Through some quick thinking on Heyes' part, and the involvement of an alleged buried treasure, they can eventually get out of there and go to Santa Marta. There Clementine falls in love with the alcalde, which is a problem for the Kid, who's supposed to be her husband. At the same time, Heyes and the Kid has their minds on the only photograph of them, which Clementine has and sometimes uses to blackmailing them into doing things for her. But things turn from bad to worse, when one of the men from the posse earlier in the episode finds them again, and makes the alcalde arrest them.
Heyes and the Kid tracks friend Georgette to borrow some money for a high stakes poker game, but finds that George has plans of her own. She intends to get the loot from a insurance fraud, that will soon be statute-barred - a diamond, hidden somewhere in the hotel where the thief was captured. Present is also a professional bounty hunter, who also wants the diamond, and the sheriff who caught the original thief. Who will find the diamond first? George, the sheriff, the bounty hunter, or the diamond-seeking animal that Heyes brings?
The boys are waiting for an old friend who wants a favour, in a small town called Buffalo. But while they wait they cross paths with two deputies who don't seem to want them there. That is, until Heyes and the Kid discovers that it's all on the sheriff's orders. The reason he doesn't want them there is that they can blow his cover, being an ex-criminal gone good. Heyes and the Kid meet with their old friend, who has a tempting offer - 80.000 dollars from a robbery, with the statute of limitation run out, buried in a safe place. The problem is, it's buried in too safe a place: the middle of a new ranch. As usual, Heyes comes up with a plan to vacate the ranch, but they didn't count on two greedy men watching their every move...
A female casino owner runs a crooked game, and nearly kills Heyes and the Kid for trying to point that out. They wind up in the care of a man and his daughter. After hearing their story of how the casino owner destroyed the man's newspaper, and how he now dabbles in new techniques for printing, Heyes gets an idea of how to use the woman's greed to their advantage - by pretending to be able to print their own bills. But the woman turns out to be more careful than they thought, and it's not until they find a way to use that against her that they can finally end her reign.
Smith and Jones balance a Mexican bandit and pretty saloon owner while they gather a herd of wild cattle as a cover for other activities.
Heyes and the Kid have been promised $500 if they arrange a meeting between ""Big Mac"" MacCreedy and his longtime competitor, Armendariz, in order to end the feud. Instead they are captured by Armendariz' men and driven off his land. But Heyes has gotten the brilliant idea of trying to use the sister to get to Armendariz, so he and the Kid tells Big Mac of all her beauty. Big Mac falls for their story and is prepared to give them $5000 if they settle the whole business. They return to Armendariz' ranch and try to sell her on the idea as well, but she doesn't seem to buy it. They're once again driven off Armendariz' land. Heyes encourages the Kid to have some faith, but when they sneak back in to talk to the sister, they are captured - to be brought to the border the next day. However, they manage to convince the sister that Big Mac is catholic, and that he desperately wants to meet her. The Kid fears that it won't be so easy to make Big Mac pretend that he's catholic - but when they tel
The guys join a cattle drive and Kid Curry finds himself accused of murder again.
When a bag of counterfeit money fall into the hands of Heyes and the Kid, they use it as collateral to get into the biggest poker game in the west. But just as Heyes get in, he runs into the Devil's hole gang - and they nearly spoil his cover story. How long will it take until the sheriff will put two and two together, and grab Heyes and the Kid? Then the banker takes a closer look at the counterfeit money, and decides he wants a piece of the action. But to get that kind of money, Heyes and the Kid would have to get the money from the robbery back. Can the Kid pull it off without Heyes' silver tongue?
Tired and weary, Heyes and the Kid discover that they are accused of burgling a bank. They decide to go there and investigate, since their amnesty is at stake. Also present is Blackjack Jenny, whose son Billy disappeared after telegraphing her about a job there. She is convinced that Billy and his friend Caleb are dead. Heyes and the Kid confront the bank manager, and manage to convince him that they are bounty hunters, and that they were on Heyes and the Kid's track far away when the burglary took place. That way he gives them the name of the woman who said that it was Heyes and the Kid who stole the money. But is there someone else involved?
The fellows get involved in a $50,000 swindle.
""Big Mac"" MacCreedy tries to get the boys to steal the Roman bust from Armendariz - again, but this time the boys refuse. But when Big Mac threatens to reveal their secret identities they agree to transport the bust to an auction after it has been stolen. While they wait for the bust to be delivered to the drop spot, Heyes and the Kid meet a bullying foreman, who makes the Kid do a little jig every time he finds the Kid still wearing his gun. Heyes can't understand why the Kid doesn't comply for the sake of peace and quiet - but a former priest, turned town drunk has an interesting idea: that the Kid is a saint who always turns the other cheek.
Smith and Jones meet an unlucky lady evangelist, a stubborn Indian agent, a devious woman, and a hotel keeper when they decide to spend time in the deserted town of Apache Springs while retrieving buried gold from hostile Indian lands.
After helping a pair of nuns whose wagon has broken down, Smith and Jones run into Harry Briscoe who claims one of the nuns is a fake who stole $30,000 from a bank she worked at.
When Heyes loses his money to a crooked dealer, he threatens to expose the whole thing. But the owner of the casino calls the bluff, and Heyes and the Kid have to leave with their tails between their legs. Until Heyes creates a revenge plan, involving friend Georgette, a false necklace and selling it to the casino owner. But instead of falling for this trick the casino owner manages to steal the real necklace. Now things get really tough for Heyes, the Kid and Georgette, as the casino owner sees through their every bluff. Heyes finds out it's not so easy to out-con a con-man, but there is a solution to every problem...
Heyes and Curry are set up as witnesses for a man who kills two bushwhackers for his own reasons.
When the Kid travels alone and seems destined to be thrown in jail for not having enough money to pay for his drink, a mild-mannered female teacher rescues him. But as he tries to return the favour, the Kid is kidnapped. Soon Heyes comes to town, and puts together what happens to the Kid. But the teacher won't talk - not until Heyes uses his charms on her. Only then will he find out the real reason for the kidnapping.
Kid Curry is again falsely accused of murder and it's up to Heyes to save the day.
The guys are framed for bank robbery by an embezzling banker, but they turn the tables on him by arranging for a second bank robbery to clear their names.
The capture of Heyes and Curry represents pay dirt for a poor prospector and his family.
Smith and Jones retrieve a letter for a young lady and wind up searching for a buried Army payroll.
Curry and Heyes sneak into Tombstone looking for a witness who could clear Big Mac McCreedy of a murder charge while trying to escape the notice of sheriff Wyatt Earp.
Heyes tries to talk a runaway wife into returning to her husband while Curry distracts the gentleman with her.