Professional gunfighter Paladin was a West Point graduate who, after the Civil War, settled into San Francisco's Hotel Carlton were he awaited responses to his business card: over the picture of a chess knight "Have Gun – Will Travel ... Wire Paladin San Francisco."
Bob Wire hires Paladin, C.O.D., to escort him and his wagon load of barb wire to Anderson. What he doesn't say until they arrive is a range war is brewing and Paladin is now right in the middle of it.
Paladin is hired to find James Becker. He trails him to Monterey and discovers he has been arrested and is sentenced to work in a silver mine. Paladin finds that Becker has died in a cave-in or so he is told. The owner of the mine hires Paladin to guard a silver convoy, but first Paladin wants to find out a little more about the mine.
Paladin comes to the aid of a young sheriff from the East whose attempts to keep law and order are particularly unsuitable for a cowboy town in Wyoming.
Retired and wealthy General Crommer is dying. He asks Padadin, who holds an old grudge against him, to do him a favor. He asks him to take a message of forgiveness to another man who hates Crommer. A favor which might get Paladin killed.
Trying to locate the thieves who stole a jade chess set, Paladin ends up in a small Montana town where he becomes involved in a romance with a landlady's daughter.
Hired to prevent the construction of a dam that would imperil a town's water supply, Paladin finds that he sympathizes more with the Irish engineer who's trying to build it.
Accompanying a cavalry major on a mission to prevent a war by negotiating a treaty with an elusive Apache chief, Paladin must deal with soldiers who have caught gold fever.
A sportsman sponsors a contest, betting that no one can elude his posse in the Mojave Desert. When Paladin shows up riding a camel, the man decides that the only way he can still win is to get rid of Paladin.
An art collector hires Paladin to guide him, and his strangely childlike daughter, to the camp of a reclusive sculptor. But the collector does not tell Paladin his real reason for wanting to find the artist.
Paladin and a local hero go in pursuit of a gang of bank robbers but the hero may not be what he seems.
Fleeing banditos, Paladin seeks shelter from a peasant and his beautiful, scheming wife, their marriage at the breaking point. After being driven from their rural home, the husband hopes to appease his high-maintenance wife by returning to a city. However she eyes the urbane Paladin as the means to her own ends.
Paladin is hired to escort a Rani and her party across 150 miles of desert to a safe haven.The Rani is from a country fighting a civil war and she is to be the new leader if her side is victorious.On the journey it is noticed that they are being followed and treachery from within may be the cause of more worry.
Paladin is hired to find Colonel Celine in order to get him to sign an important document.
When Paladin goes to a mining town to promote a prizefight, his boxer is arrested and he ends up having to take the man's place in the ring -- against the Welsh champion.
Paladin agrees to capture an outlaw in return for a statue belonging to the local mission.
After being bushwhacked and having 'everything' taken, Paladin walks to the nearest ranch and manages to get hired on as a handyman.
A man who left Paladin to die in his place writes to Paladin and asks for his help.
Robert Ceilbleu hires Paladin to protect his father from a Comanche war chief who has sworn to kill him. After arriving at the remote cabin of William Ceilbleu, he learns the reason for the Indian's hatred.
An Armenian winemaker hires Paladin to find his runaway daughter and break up her ill-considered romance with a cowhand.
Dr. Phyllis Thackeray diagnoses the cook at the Barton Ranch with smallpox. All the cowhands may be infected and need to be vaccinated. Dr. Thackeray sends for the one man she thinks can help.
Sid Morgan hires Paladin to protect him from someone who is trying to kill him. After killing the gunfighter who was following them, Paladin finds out the real reason Morgan hired him. He then hands out his own brand of justice.
Paladin finds himself reluctantly drawn into a deadly dispute between two brothers who are also old aquaintances.
Arriving in a weird tent town to return money to a prospector, Paladin finds himself charged with the man's murder and tried by a kangaroo court.
Corporal Henry Carver deserted from the Cavalry. Carver's mother hires Paladin to find him and get him to either return voluntarily or bring him back by force.