The BEST Episodes of Painkiller Jane

Every episode ever - ranked by fan votes!

Last Updated: Sep 25, 2021

Network: Syfy

In a very imaginable future, the world battles terrorism and unrest. Out of this chaos emerges a new hero: Jane Vasco, a.k.a. Painkiller Jane Once the DEA's top agent, Jane Vasco is formidable, both mentally and physically. As a child, her father nicknamed her Painkiller Jane, describing her ability to mentally push through even the most painful situations. But her strength is about to be tested. Jane is recruited by a covert government agency dedicated to containing and, if necessary, neutralizing the threat of "Neuros" No one knows what caused the aberrations that led to their enhanced abilities, which range from from telekinesis and telepathic suggestion to induced hallucinations. During her first investigation with her new team, Jane discovers that she too possesses an odd ability: she can't be killed.

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Something Nasty in the Neighborhood

#1 - Something Nasty in the Neighborhood

Season 1 - Episode 12 - Aired Jul 6, 2007

Jane and Connor go undercover in a small town, posed as a married couple, after a federal agent's disappearance prompts an investigation.

star 8.13
16 votes
Directors: Michael Robison
Writers: Lawrence Hertzog
What Lies Beneath

#2 - What Lies Beneath

Season 1 - Episode 19 - Aired Aug 31, 2007

The team respond when several incarcerated Neuros revolt and launch a prison break.

star 8.13
16 votes
Directors: Matt Hastings
Writers: Mike Goldberg

#3 - Endgame

Season 1 - Episode 22 - Aired Sep 21, 2007

Several dangerous Neuros launch a prison break after an emergency at NICO.

star 8.12
17 votes
Directors: Farhad Mann
Writers: Gil Grant
Higher Court

#4 - Higher Court

Season 1 - Episode 7 - Aired Jun 1, 2007

The team investigate the suicides of individuals placed in witness protection and discover a Neuro who is capable of creating hallucinations.

star 8.11
28 votes
Directors: Matt Hastings
Writers: Gillian Horvath
The Beast of Bolnar

#5 - The Beast of Bolnar

Season 1 - Episode 20 - Aired Sep 7, 2007

The residents of a small village are plagued by an invisible presence which is attacking and murdering the villagers.

star 8.00
15 votes
Directors: Farhad Mann
Writers: Charles D. Holland

#6 - Reflections

Season 1 - Episode 21 - Aired Sep 14, 2007

Andre encounters a Neuro from his past that was chipped, but he learns that she has regained her abilities and she has a grudge.

star 8.00
14 votes
Directors: Matt Hastings
Writers: Matthew Carpenter
The Amazing Howie

#7 - The Amazing Howie

Season 1 - Episode 14 - Aired Jul 20, 2007

Howie is a magician who can miraculously perform the impossible, which prompts Riley to begin an investigation into possible Neuro activity.

star 7.85
20 votes
Directors: Matt Hastings
Writers: Lisa Klink
Nothing To Fear But Fear Itself

#8 - Nothing To Fear But Fear Itself

Season 1 - Episode 5 - Aired May 11, 2007

When inhabitants of an FBI safe house start to experience unexplained dreams and visions, Jane and crew must investigate potential Neuro activity.

star 7.83
35 votes
Directors: Matt Hastings
Writers: Lawrence Hertzog
The Healer

#9 - The Healer

Season 1 - Episode 15 - Aired Jul 27, 2007

Sabotage hinders Jane's efforts to catch a Neuro, she becomes suspicious of a faith healer that she has been visiting.

star 7.81
16 votes
Directors: Michael Robison
Writers: Charles D. Holland, Frank Lupo
Jane 113

#10 - Jane 113

Season 1 - Episode 18 - Aired Aug 24, 2007

Jane discovers the disturbing truth about her abilities while searching for a Neuro who escaped the team.

star 7.75
16 votes
Directors: Peter DeLuise
Writers: Lawrence Hertzog
Portraits of Lauren Gray

#11 - Portraits of Lauren Gray

Season 1 - Episode 10 - Aired Jun 22, 2007

A young woman suddenly ages overnight, Jane and Maureen go undercover to find the cause.

star 7.73
26 votes
Directors: Peter DeLuise
Writers: Robert Gilmer
The League

#12 - The League

Season 1 - Episode 13 - Aired Jul 13, 2007

An investigation is started after Neuros begin to die before the team can apprehend them.

star 7.71
21 votes
Directors: Paul Ziller
Writers: Jimmy Palmiotti
Friendly Fire

#13 - Friendly Fire

Season 1 - Episode 8 - Aired Jun 8, 2007

Awakening in a hospital Jane learns that she murdered Riley. Meanwhile, Maureen investigates a doctor researching Neuros.

star 7.71
31 votes
Directors: David Tennant
Writers: Gillian Horvath
Trial by Fire

#14 - Trial by Fire

Season 1 - Episode 9 - Aired Jun 15, 2007

Connor is arrested for arson and murder while out hunting for a Neuro, which is believed to have started numerous house fires.

star 7.62
26 votes
Directors: J.B. Sugar
Writers: Lawrence Hertzog
Ghost in the Machine

#15 - Ghost in the Machine

Season 1 - Episode 11 - Aired Jun 29, 2007

Connor suffers a series of unfortunate events, believing it to be coincidental. However, he learns that members of his former police squad have died of strange causes.

star 7.55
22 votes
Directors: Brent Clackson
Writers: Gillian Horvath
Catch Me if You Can

#16 - Catch Me if You Can

Season 1 - Episode 4 - Aired May 4, 2007

A Neuro who can see the future warns Jane and the team of their impending death on the day they arrest him. Meanwhile, the team is disturbed by the psychic's purchases

star 7.50
44 votes
Directors: Farhad Mann
Writers: Lisa Klink
Piece of Mind

#17 - Piece of Mind

Season 1 - Episode 3 - Aired Apr 27, 2007

A Neuro with the ability to steal memory and knowledge preys on Riley putting the security of the entire operation in jeopardy.

star 7.45
53 votes
Directors: Michael Robison
Writers: Charles Heit

#18 - Breakdown

Season 1 - Episode 6 - Aired May 18, 2007

While investigating psychiatric patients who share the same unusual nightmare, Jane and Maureen suspect a Neuro has the ability to use nightmares as weapons.

star 7.34
59 votes
Directors: William Waring
Writers: Lisa Klink

#19 - Playback

Season 1 - Episode 17 - Aired Aug 17, 2007

A Neuro causes the team to become stuck in a timeloop, causing them to relive the same day repeatedly. Meanwhile, the Neuro who caused the timeloop tries to finish an assassination.

star 7.20
44 votes
Directors: Matt Hastings
Writers: Frank Cardea, George Schenck
Thanks For the Memories

#20 - Thanks For the Memories

Season 1 - Episode 16 - Aired Aug 3, 2007

Jane seeks help from a Neuro after Brian (Jane's boyfriend) and Joe forget who she is, the Neuro has the ability to remove and store memories within his mind.

star 7.17
18 votes
Directors: Charles Heit
Writers: Michael Robison

#21 - Pilot

Season 1 - Episode 1 - Aired Apr 13, 2007

Jane Vasco with the help of a new covert government unit must track down and contain the spread of "Neuros," genetically altered humans with extraordinary powers.

star 6.91
227 votes
Directors: Nick Copus
Writers: Gil Grant
Toy Soldiers

#22 - Toy Soldiers

Season 1 - Episode 2 - Aired Apr 20, 2007

When military stockpiles start to go missing before a presidential visit, Jane and the team are forced into high alert. Meanwhile, Jane confronts a Neuro with the ability to control the dead.

star 6.68
139 votes
Directors: Michael Robison
Writers: Lawrence Hertzog