Bionic Woman is a re-imagining of the original television series, The Bionic Woman. The series revolves around bartender Jaime Sommers, who is saved from death after receiving experimental medical implants. While adjusting to her new bionic powers and raising a rebellious younger sister, Jaime agrees to work for the Berkut Group, a quasi-governmental private organization that performed her surgery.
Jaime's new mission requires her to attend college posing as a British transfer student in order to investigate a professor suspected of illegal activities. However, her task becomes complicated when she falls for the teacher's assistant, who is also a suspect.
Jaime continues to gradually adjust to her new bionic life - all while trying to maintain the normal aspects of her human life. She also befriends a stranger who appears to be very friendly and goes on her first mission.
When a man plans to sell a list with names from both the Berkut Group and the CIA, the companies team up to catch him. Jaime and Tom are partnered for the mission in Paris, where they find themselves struggling to balance their flirting with the task at hand. Finally, Becca tries to impress a boy and gets arrested, prompting Jonas to bail her out.
Jaime and Antonio are sent to stop an assassination plot of a head of state on U.S. soil. Jaime runs into a problem though when she overhears a conversation between the assassin and Antonio, leading her to question whether or not she can trust Antonio anymore. Also, Jaime invites Tom over for dinner so he can meet Becca.
Jaime Sommers is fatally injured in a car accident but saved when her boyfriend, Will Anthros, provides her with bionic implants. Now adjusting to greatly augmented speed, strength, and agility Jaime escapes the organization that provided the operation that saved her life, but is assaulted by Sarah Corvus, another recipient of bionic implants who has been attempting to kill Will. In a sub plot of the episode, Will's father Anthony Anthros escapes from prison.
Jaime is sent on an assignment that requires her to rescue an American doctor who is working in Paraguay. While there, she discovers the truth about her life expectancy.