Andy Richter Controls The Universe. HIS own Universe. And we get to see what that looks and sounds like every moment. Even when the moments are not pretty. Andy is a short story writer, who makes his living by working at a huge faceless company in present day Chicago, writing Technical Manuals. In his active, fertile, writer's imagination, we see (and hear as he narrates) the stories of his daily life, as they should be, could be, might be, and even actually how they are. Andy shares his office with the company's newest employee, and Andy's newest friend, the frail, jumpy, odd, loveable Byron. Also inhabiting Andy's world is his best friend Keith, who is "so good looking" that Andy must fight his own "prejudice against the 'attractive,' who seem to get everything they want, unlike ordinary humans." Supervisor Jessica.
While working on a manual for a deep frier, Byron proposes livening it up with a cartoon character. Andy tries to sarcastically shoot the idea down by suggesting a cartoon dog that tells people stupidly obvious facts, but when executives aren't thrilled with Andy's manual, Byron suggests the "Duh Dog" and the idea takes off. Meanwhile, Keith becomes addicted to fried food.
Andy finds out that the reason Wendy moved to Chicago was to pursue her dream of singing, but her career hasn't taken off. When Wendy decides to quit singing and pursue her other dream of marriage and a family, Keith, put on the spot about their relationship, conspires with Andy to help Wendy's singing career.