In his basement in San Francisco, boy-genius Quinn Mallory unlocks the doorway to an infinite number of Earths. During a test run, Quinn invites co-worker Wade Wells and his teacher Professor Maximillian Arturo to see his new invention. But an increase in power and an early departure leave all three, plus a washed-up soul singer named Rembrandt "Crying Man" Brown, lost in a parallel world. Now they must "slide" from world to world, not only adapting to their changing surroundings, but also trying to get back to their world. Will they ever make it home?
The Sliders arrive in the middle of a rally, surprisingly being held in their honor. They learn they are the subjects of a religion called Slidology, founded by a man with psychic abilities. He has been following their adventures and warns that on their next slide, they will all die.
A malfunctioning timer deposits the Sliders underwater in the Pacific Ocean. A merchant ship picks them up, but is taking them out of their sliding radius and decreasing the likelihood of a safe slide. Their only chance is to join up with a pirate crew to get back to California.
The Sliders arrive at a mental institution in the middle of an unusual riot. Rembrandt and Maggie escape capture, but Diana and Mallory get left behind. While Mallory has managed to pose as a doctor, Diana is mistaken for a patient and undergoes the process of her brain being remapped.
The Sliders are lost in the desert, but happen upon an archaeological dig. They soon find, however, that the dig is unearthing a buried Los Angeles and that the locals consider Rembrandt a deity.
The Sliders arrive on a world where millions play in highly realistic arcade simulations. Rembrandt and Mallory take part in separate simulations, until they discover Maggie and Diana have been forced to play characters in these simulations, where each "death" experienced is real.
On a world of magic and dragons, Quinn is mistaken for a wizard and kidnapped by an evil warlock bent on immortality. Meanwhile, Wade tries to help Rembrandt's love troubles with a love potion, but it backfires and makes Rembrandt fall in love with her.
The Sliders arrive on a world where Prohibition still exists, only it was caffeine that was outlawed. They meet a nightclub owner whose lover was murdered by a gang dealing in bootleg coffee.
Wade and Rembrandt recall their slide to a world plagued by earthquakes and populated by primitive people. Wade falls into a deep chasm and Quinn goes to rescue her, while Rembrandt learns of Arturo's illness.
After barely escaping a world engulfed in flames, the Sliders now find themselves in a Los Angeles dependent on the sale and production of oil. Unfortunately, they learn they've brought along a piece of the fire from the last world and that it has a mind of it's own.
While on vacation, Quinn and Rembrandt get mixed up in an illegal snake deal and find themselves stuck in the middle of no where surrounded by deadly snakes. Meanwhile, Wade and Maggie get involved with a shady man in their search for the others.
On a world where a group of social misfits have learned to torture people by entering their dreams, Wade becomes a target of the group's leader.
The Sliders arrive on a world where a strange bacteria transformed the inhabitants into flesh-eating zombies. When Quinn is bitten, he begins to turn into one of them.
The Sliders arrive on a small island, with a very sick Maggie in tow. While looking for help, Rembrandt, Mallory and Diana meet the monks of a secluded monastery. Reluctantly, the monks allow them to stay and give Maggie medical attention. But the Sliders soon learn the monks have a secret and won't allow them to leave.
A creature embeds a parasite in Maggie just before the slide, which takes the Sliders to a world where young adults are used in a mandatory organ-donor program. The others will have to find Maggie before she finds the perfect mate and lays her eggs.
On a world where the American government is a monarchy, Rembrandt is mistaken for his double and discovers that he is about to be a father of royalty. The only problem is, on this world, it's the men who give birth to children.
The Sliders arrive on a world where Maggie's double was a heroic astronaut and loved by the public. When she is mistaken for her double, the public gets excited. After being kidnapped by the mysterious Leader, Maggie is taken by the government where she must confront her father.
Wade falls under the spell of a rock band's charismatic lead singer, who is really a vampire and looking to use Wade to get the timer. Meanwhile, the others try to track down Rickman.
The Sliders land on a world with little water and come to the aid of a mysterious young woman whose gift to find water is being exploited by a group of thugs.
The Sliders arrive in a barren wasteland, where the timer is inoperable. Worse yet, they find themselves forced to take part in a never ending battle between Kromaggs and soldiers from Quinn's home world, who are guarding a mysterious bunker.
The Sliders land on a world where San Francisco is a national park dedicated to the preservation of dinosaurs, which is home to a deadly Allosaurus. A bad fall causes Arturo to injure himself and lose the timer. Quinn goes out alone to search for it, while the others hide out from the Allosaurus in a cave.
Rembrandt experiences a strange dream in which Wade is trying to contact him and bring him to her. The others have their doubts until a spatial fold opens before them. On the other side, they find Wade is somehow being used in a plan to attack Kromagg Prime.
The Sliders arrive on a world where virtual reality is a normal part of life. After Maggie is injured in an explosion, she awakens in a hospital to find they have missed the slide. The only way to go is to build a new timer, but is everything what it seems?