Jackie O'Hurley, a strong-willed and brilliant -- but very flawed -- emergency room nurse in a complicated New York City hospital. A lapsed Catholic with an occasional weakness for Vicodin and Adderall to get her through the days, Jackie keeps the hospital balanced with her own kind of justice. Every day is a high wire act of juggling patients, doctors, fellow nurses and her own indiscretions.
Jackie and Kevin consider enrolling Grace in private school; the stoic Dr. O'Hara must endure the emotional thanks of a boy whose twin brother she saved; Zoey loses a patient for the first time.
Jackie and her husband, Kevin, become concerned that their older daughter Grace is suffering from anxiety disorder; hospital administrator Mrs. Akalitus drinks Jackie's Percoset-laced coffee.
Longtime ER nurse Jackie Peyton bends the rules to bring some good from a patient's senseless death, while concealing her addiction to a pain killer she gets from her boyfriend, the hospital pharmacist.
Jackie breaks several rules and regulations to help a 10-year-old girl caring for her lupus-stricken mother; Mrs. Akalitus accidentally tasers herself; O'Hara treats Zoey to a meal at a four-star restaurant.
Jackie and Grace begin mother-daughter tap class. Coop threatens to expose Jackie for falsifying a donor’s record. Jackie has forgotten to remove her wedding ring, and needs to get it off before meeting Eddie for a quickie.
Jackie is caught off-guard when a nurse (Judith Ivey) she used to work with, who is dying of lung cancer, asks Jackie to help end her life. Meanwhile, Coop’s mother (Blythe Danner) is admitted with a gall bladder attack. We learn that he is the only son of lesbians…a fact that delights Jackie and O’Hara.
An elderly patient checks in who has been treating his heart disease with chicken soup; Jackie discusses her daughter's anxiety with Dr. O'Hara; Eddie learns that he is to be replaced by a pill-dispensing machine.
A man is admitted with a steak knife sticking out of his chest. Eddie gives Jackie a Cartier bracelet for their one-year anniversary, but she rejects the gift. A baby is left in the nurses’ station and Akalitus takes the infant to her office.
Jackie admits a patient she has treated before. As his condition worsens, Zoey questions whether Jackie did enough to help him on his previous visit. Jackie’s drug use starts to cause spontaneous nose bleeds.
Following HR's inquiry into the missing drugs, Mrs. Akalitus puts Jackie on probation. Coop plans his wedding. Jackie's daughter Grace wants medication for her anxiety disorder.
Watch Now:iTunesJackie catches Grace with a boy at a carnival and takes her, not before deleting the number from the boys phone. While at the carnival, Grace announces to Fiona and Zoey that Jackie went to rehab. Jackie goes to an AA meeting with Charlie only to find out that he is using again. Kevin forced Eddie to tell him what Jackie took, when they were having the affair, before telling Eddie to tell Jackie to "Kiss her kids goodbye". Jackie almost relapses when a patient gives her their medications. She throws them in a dumpster and then tries to retrieve them and falls in. She then gets out and walks away pill free. Charlie is revealed to be Dr.Cruz"s son.
Watch Now:AmazoniTunesJackie asks Eddie to stop spending time with Kevin. A pharmaceutical company rep provides Jackie with drugs.
Eddie tells Jackie that he now considers Kevin a real friend and can no longer lie to him. Jackie is remorseful when she learns that O'Hara is looking for a new employer. Akalitus announces that All Saints may get a visit from the First Lady.
Missing her family and adjusting poorly to single life, Jackie invites Kevin to meet her at a cafe but finds herself served with divorce papers instead of lunch; an attempted double suicide trauma case comes into the E.R.; Cruz institutes a draconian new dress code that is not a hit with his staff; Zoey looks for a new roommate and finds one in the lonely Jackie.
Watch Now:AmazoniTunesWhen Cruz learns about Jackie's rehab, he takes revenge on coworkers who have been covering up her drug problems. Meanwhile, Eddie is deposed by Kevin's lawyer; a dumped Lenny decides to take off for Europe; and Coop accompanies O'Hara to her ob-gyn appointment.
Watch Now:AmazoniTunesAfter breaking up with Kevin, Jackie has to realize she needs professional help. Meanwhile, a new director at the hospital makes some personnel changes and Kevin finds out about Jackie and Eddie's affair.
Jackie discovers that a new temp nurse is abusing drugs, but when she confronts him, he calls her on hypocrisy; Mrs. Akalitus still has the foundling infant left at the hospital; Coop reveals to Eddie that Jackie has a child.
Jackie is nervous about her date with Frank, so Zoey and Thor help her get ready and Eddie offers some friendly pointers. Prentiss misdiagnoses an injured dancer, but Akalitus and Coop catch his mistake before the patient leaves. Mike Cruz calls Jackie in a moment of need.
Kevin's younger sister Tunie visits after a breakup with her boyfriend. Lenny prepares a surprise romantic picnic for Zoey. Two street vendors are brought in after a turf war turns violent. Akalitus fights Catholic bureaucrats over the hospital's chapel.
Jackie and Frank have sex for the first time; Akalitus has an extra spring in her step; Coop wants to take his mentoring of Carrie to the next level; Kevin and Grace show up at the hospital after Kevin found a bag of pills in Grace's bag, Jackie delivers Grace to Akalitus and Thor who give her a scared straight tour of the emergency department; Grace has to assist Jackie with a man who collapses on the sidewalk; Jackie wants the girls to live with Kevin.
Kevin decides to buy Jackie a new wedding ring. At work, the automated pill machine replaces Eddie. A movie critic (played by Victor Garber) is admitted with a broken elbow.
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