CSI's gritty approach to crime known as forensic science makes its way from Las Vegas to the streets of Florida in CSI: Miami. A whole new team of crime scene investigators is on hand to probe the seamy underside of Miami.
In this thrilling season finale, the loss of one of their own is the first hit the lab will take. Getting back to the lab to process the evidence, they find it has been taken over by Federal Agents looking for stolen money from a previous case.
In the first of a two part episode, Horatio once again has to tangle with his ex, Julia, who has it out for him. Someone is out for Calleigh, and is compromising their investigation in the process.
The team is sent to investigate the death of a local celebrity, who is found murdered in her bathtub. The list of suspects includes her musician boyfriend, her assistant and her rival. The search for a young abducted girl is triggered, and Horatio tells Delko of Marisol and his plans.
A former high school football star is murdered at a reunion, the CSIs must find the killer. The victim was the big man on campus in high school and there are a lot of guests at the reunion with reasons to resent him all these years. Now, the team must investigate everyone, from the head cheerleader to the school misfit, to see who held a decade-old grudge big enough to kill. Meanwhile, Horatio and Delko arrive at a crime scene and discover that it's already been processed, leading Horatio to uncover further information about his brother possibly being alive.
The Mala Noche gang trial is obstructed when the defendant goes free with the help of the witness who is testifying. When a hit ordered by the Mala Noche gang on Horatio finds the people he loves lives are in danger. Delko finds that an ex-lover is disturbing any woman who he is now close to.
After a large yacht slams into a major Miami bridge, the team finds that the man steering the boat was shot and killed before the accident. The victim's wife reveals that their son had been kidnapped and her husband was handing over the ransom – three million dollars worth of jewels. But when the team learns that the jewels were fake, the investigation leads them into a dangerous situation at a jewelry shop that may contain crucial evidence, where Horatio must face the unimaginable when one of the team is killed in the line of duty.
Evidence leads the CSIs to believe that someone started a massive fire in the Everglades in order to cover up a murder. Local prisoners are brought in as free manpower to help fight the wild fire in the Everglades. However, when a serial killer escapes the scene, Horatio must track him down before he strikes again. Meanwhile, the body of a local college student is found shot to death and the fire has destroyed the crime scene and the evidence. However, when the team uncovers an illegal moonshine operation and homemade ammunitions in the vicinity, the CSIs uncover the real reason why the boy was out there.
A woman is killed during a posh party at an exclusive waterfront estate when a man opens fire on the proceedings from a cigarette boat. When a former con is arrested, he acts as his own lawyer and proves to be smarted than he appears. Complicating matters is the fact that the leading witness in the case is the dead woman's 10-year-old son, whom Horatio wants to protect, refusing to let him testify.
When the CSIs find a woman swallowed whole and killed by a gigantic snake, they uncover a covert drug smuggling operation. Evidence leads Horatio and the team to a drug smuggling operation where large snakes are suspected of be being used to bring illegal drugs into the country to avoid detection by customs. However, when Horatio finds that Clavo Cruz, a nemesis of Horatio's who hides behind his diplomatic immunity, may be behind the operation, the team must find a legal way to put the criminal behind bars. Meanwhile, Wolfe must find the truth when two women each claim that they are the real victim of identity theft and the other is the culprit.
A truck carrying weapons that were confiscated from previous crimes are now back on the streets of Miami. An old enemy of Horatio's puts the lives of two CSI's in harms way after a confiscated missile is launched into courthouse allowing Clavo Cruz to escape during his arraignment and injuring one CSI and the fatality of another CSI.
The team investigates a modern-day piracy off the coast of Miami after six bodies are discovered floating in the ocean tied together by rope. Horatio suspects that a ship was hijacked with some of the crew killed and then dumped overboard. Evidence suggests that other crew members might have escaped on a life raft. Using radar and GPS technology, the CSIs find survivors but their stories don't match. Now, Horatio and the team must learn what really happened out in the ocean as they find themselves investigating the seamy underbelly of Miami's militias and arms dealers.
Horatio and the team are trying to figure out how to free an innocent young man after a harsh interrogation with Frank Tripp sends him to jail.
As a huge tsunami heads directly towards Miami, a ten-hour warning gives citizens just enough time to evacuate the city. In the chaos, two people are killed in a parking lot and the evidence leads Horatio to discover a plot to rob a bank timed to take advantage of the evacuation. However, as the CSIs close in on the robbery already in progress, they find that it's a more elaborate crime than they previously thought. In the wake of the storm, Ryan and Alexx discover a body washed up from a local cemetery that may have a different cause of death than originally recorded. Meanwhile, Horatio suspects that Yelina is being physically abused by her boyfriend, IAB's Rick Stetler.
Horatio, Calleigh and Speedle investigate the death of an exotic male dancer found dead after a sexual party, and must dig through the evidence to discover a motive. Meanwhile, Eric and Megan investigate the death of a man involved in diving that mysteriously died after climbing onto a random boat.
After a bitter custody battle, shots are fired outside the courthouse. Bullets fly and the target is the little girl's mother. Horatio goes after the father, who he suspects may not be the girl's biological father after all. However, when the mother's shady past is uncovered, the team finds that she has a lot of enemies who would like to take a shot at her. Meanwhile, Calleigh's father returns to the crime lab for her guidance but for an unexpected reason.
While investigating the murder of man hired to make dirty bombs that terrorists intend to set off in Miami, Horatio finds the bloody fingerprint of his brother, Raymond, who he believed to be dead. However, when Raymond's son is kidnapped, he emerges from deep undercover and the estranged brothers must work together to save the boy. Meanwhile, while processing a crime scene, an unknown assailant holds a gun to Calleigh's head and, after a deadly confrontation in her gun lab, she is left doubting that she can continue as a CSI.
Horatio and his team must uncover the evidence in the brutal murder of an entire family in their own home. The only survivors are a blood-soaked toddler, and the father who's in surgery. The immediate assumption is that the mother is responsible – post-partum depression – but the evidence discloses a different outcome.
Horatio's life is changed forever when he learns important information about his deceased brother. Horatio must now figure out what to do with this information about his brother, Raymond, and whether or not to tell Yelina. Meanwhile, the team investigates when a woman is murdered at a crowded bar after she's approached by a female employee of a service that helps men pick-up women. Also, when Delko loses his badge after some reckless behavior and it's used in a crime, he must locate the badge before it's used again.
In the second part of the two part episodes, Horatio deals with his past and the rest of the team works to rescue Calleigh from kidnappers.
The CSIs must find the killer after a young woman is pushed in front of a moving bus. Alexx finds a bruise shaped like a hand imprint on the victim's back, proving that she was pushed in front of the bus, and her boyfriend, Jay Seaver, is the prime suspect. When one of Jay's office rivals also turns up dead, Jay reveals that he has a psychotic stalker, Claudia, who he thinks might kill to please him. However, when Jay hires a lawyer to protect Claudia, Horatio suspects that Jay may be more involved than they thought. Later, a man's body is discovered down an elevator shaft in a nearby building, and there is evidence to link the victims to a common killer. Meanwhile, Calleigh's father seeks her help when he fears that he may have killed someone after a night of drinking, and Horatio assigns a new CSI, Ryan Wolfe, to the case.
A nude man is found tied to his bed, having suffocated on a rag stuffed in his mouth while he was being sexually assaulted. Meanwhile, while investigating the murder of a crematorium owner, the CSIs discover dozens of bodies that were never cremated.
A dead man with a slit throat and a partially burned face is discovered on a Miami beach, along with an unconscious young girl who was beaten and thrown into the ocean. The investigation leads Horatio to a prominent Florida family and its steely patriarch, who was once involved in a mysterious case that has plagued Horatio for years.
Horatio is quick on the scene when an armored truck carrying $3.2 million is robbed in a daring downtown heist. During the holdup, the driver is killed and Horatio guns down one of the two thieves. The other escapes with the loot, but the money turns out to be counterfeit. The team must figure out what happened to the bank's money before it was replaced with fake bills. Making the day even worse for Horatio, Yelina spies him with his niece and assumes the girl is his illegitimate child, not her own late husband's daughter.
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