A woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
When Amy’s parents and Sheldon’s family arrive for the wedding, everybody is focused on making sure all goes according to plan – everyone except the bride and groom.
Sheldon tries to teach the guys a lesson after they cut him out of a potentially valuable Bitcoin investment. Also, a seven-year-old video reveals a secret about Leonard and Penny's relationship.
Amy gives Sheldon an answer to his proposal while Howard and Bernadette struggle with some unexpected news.
When Sheldon learns that his mother won’t attend his wedding unless he invites his brother, Georgie, he and Leonard travel to Texas to end a family feud. Also, the Wolowitz kids inadvertently infects Amy, Bernadette, Wolowitz and Koothrappali with pinkeye.
Sheldon’s comic book store experiences changes when writer Neil Gaiman puts Stuart’s store on the map. Also, Koothrappali takes credit for Penny’s astronomical discovery, and friendships are threatened.
Sheldon and Amy try to eliminate stress from wedding planning by applying math to the process. Koothrappali “breaks up” with Wolowitz after realizing his best friend is actually hurting his confidence.
Sheldon and Bert collaborate on a research project, despite Sheldon's embarrassment. Also, Penny and Bernadette coach Koothrappali on how to navigate his relationship with Ruchi.
When Sheldon petitions Wil Wheaton to appear on the new Professor Proton show, Wil offers a role to Amy instead. Also, Penny gets angry when she thinks the female protagonist in Leonard's novel is based on her.
Sheldon and Koothrappali confide in Bernadette when they can't handle Amy and Wolowitz working together. Also, Penny and Leonard learn new tactics for how to deal Sheldon from an unlikely source.
Sheldon goes to Vegas to win money for science. Also, Penny and Bernadette take Amy wedding dress shopping, but her terrible choice entangles them in a web of lies.
To discover who would be most qualified to be best man and maid of honor at their wedding, Sheldon and Amy subject their friends to a series of secret experiments. Also, Penny reveals her true feelings about Amy.
When Leonard learns Sheldon is the president of the tenants association, he decides to run against him. Also, Bernadette encourages Wolowitz and Koothrappali to find the owner of a drone after they find it in the backyard.
Sheldon goes head-to-head with Wil Wheaton for the role of the new Professor Proton. Also, Penny steps in to take care of Halley when Bernadette and Wolowitz both wind up on bed rest.
Leonard and Wolowitz are furious after they learn Sheldon went to work with the military behind their backs. Also, while Bernadette is on bed rest, she asks Raj to do some digging when she suspects Ruchi is trying to steal her job.
A brilliant but reclusive scientist, Doctor Wolcott, invites Sheldon to his cabin in the middle of nowhere, and Leonard, Raj and Howard go along for the trip. Also, Penny and Bernadette improvise after Amy doesn’t like the tame bachelorette party they planned for her.
Leonard angers the university - and the entire physics community - after he gives an embarrassing interview. Also, Amy and Bernadette bond over having to hide their success from Sheldon and Howard.
Koothrappali finds himself in the middle of domestic drama when he learns the woman he's dating, Nell, has a very upset husband, Oliver. Also, when Sheldon rents his old room back for a quiet place to work, he drives Leonard crazy by being a model tenant.
Sheldon and Wolowitz plan birthday celebrations for Amy and Halley, respectively. Also, Leonard receives a Christmas letter from his brother that causes him to spiral out about his own lack of accomplishments.
As Sheldon stresses about picking a wedding date, Amy tries to convince him he has a more laid-back side. Also, Koothrappali and Stuart compete to win the heart of Bernadette's new coworker, Ruchi.
Wolowitz and Sheldon bond when they drive to the desert to shoot off a model rocket. Also, when Leonard's mom, Beverly, finds a new best friend in Penny, it rubs Leonard the wrong way.
Leonard jumps through hoops to help secure the perfect wedding venue for Sheldon and Amy. Also, Bernadette and Wolowitz have a hard time deciding who should stay at home with the kids and who should go back to work.
Penny gets the opportunity to host Bill Gates at work when his company wants to partner with her pharmaceutical company. Also, Leonard, Koothrappali and Wolowitz do everything in their power to meet him, while Sheldon thinks he is the victim of an April Fools prank.
When Bernadette won't go into labor, all her friends try different tactics to get things started. Also, Wolowitz confronts Bernadette after Amy accidentally reveals she's already chosen their son's name.
When Sheldon kicks Amy out to work solo, she and Leonard bond during a series of science experiments. Also, Bert the geologist replaces Wolowitz in the band Footprints on the Moon, and Sheldon finds Penny a surprising source of scientific inspiration.
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