The BEST episodes of Painkiller: The Tylenol Murders

Every episode of Painkiller: The Tylenol Murders ever, ranked from best to worst by thousands of votes from fans of the show. The best episodes of Painkiller: The Tylenol Murders!

Using hours of exclusive archival footage, the five-part docuseries transports viewers back four decades to the moments after a twisted killer laced Tylenol pills with cyanide and killed seven people in the Chicago area. Fear and panic shot across the country, with no one knowing how widespread the poisonings were.

Last Updated: 1/13/2026Network: Paramount+Status: Ended

7.44

27 votes

#1 - In Plain Sight

Season 1 - Episode 5 - Aired 10/10/2023

Decades pass. Victims' families remain haunted. Was the killer hiding in plain view all along? Could DNA technology crack this cold case?

Watch Now:Amazon

7.25

28 votes

#2 - The Man in the Photo

Season 1 - Episode 2 - Aired 10/10/2023

Suspects emerge. A chilling letter and a leaked surveillance photo of a mystery man offer new clues. Could he be the person who poisoned the pills?

Watch Now:Amazon

7.23

31 votes

#3 - Back from the Dead

Season 1 - Episode 3 - Aired 10/10/2023

As police ramp up their manhunt for prime suspect James Lewis, the makers of Tylenol execute a multimillion-dollar PR campaign to save the brand.

Watch Now:Amazon

7.11

44 votes

#4 - It's Gotta Be the Tylenol

Season 1 - Episode 1 - Aired 10/10/2023

It's 1982 and 7 people including a child are dead after taking Tylenol laced with cyanide. A paramedic and a nurse rush to piece together the truth.

7.07

27 votes

#5 - The Ties That Bind

Season 1 - Episode 4 - Aired 10/10/2023

Reporter Brad Edwards sets off to find James Lewis, the prime suspect in the Tylenol murders, and traces missed clues and chilling secrets of Lewis' past.

Watch Now:Amazon