Dr. Quinn, Medicine Woman was a show that focused on Dr. Mike, a woman doctor in a time when that was unheard of. It started with her journey to Colorado Springs to be the town's physician after her father's death in 1868. The show focused around the town that she loved, treated and it also focused on the three children, Matthew (Chad Allen), Colleen (Erika Flores, later Jessica Bowman) and Brian Cooper (Shawn Toovey), whom she had to raise after their mother died from a rattle snake bite. In the later years, the show focused on Dr. Mike and Sully (Joe Lando) who got married and had a daughter towards the end of the shows successful run.
Dr. Mike and Sully go to Reverend Johnson for a honest discussion regarding their upcoming marriage. After originally agreeing they have no conflicts, the couple begin reliving their past difficulties since they first met.
Dr. Mike injures herself after the other women have turned back on their quest to climb Pike's Peak. Sully steps in for his wife on the council to thwart Jake and Preston's casino plans. Grace, Myra, and Dorothy change their minds and head back up the mountain.
A teenage Belle Star robs the saloon with the Younger brothers and is shot. Dr. Mike takes her home in an effort to show her a real home life, attempting to turn her from her life of crime.
Arriving in Washington, Dr. Mike and Sully find it difficult to find anyone to listen to their concerns. Sully is arrested for army desertion while a plot against the president is overheard. Michaela must break Sully out of jail to expose the conspiracy.
Dr. Mike discovers a lump in Dorothy's breast and tries to convince her to have surgery. Hank tries Ladies Night at the saloon, and Jake and Loren have a plan to get free drinks. Colleen deals with hurtful boyish pranks from classmates.
Elderly Abner Foley comes to town looking for alternative treatment and a very friendly dog adopts Jake Slicker. The rest of the town looks forward to the costume party but first Brian must face a very big fear.