Vanessa Helsing, distant relative of famous vampire hunter Abraham Van Helsing, is resurrected only to find that vampires have taken over the world.
Vanessa makes a horrific decision to save her daughter; Axel and a former ally struggle to survive in the wild; a group of juvenile delinquents come face to face with a sadistic vampire.
At a mountain stronghold, secrets of the Van Helsing family are unearthed and the true face of evil is exposed; a climactic battle between humans and vampires leaves humanity's fate in question.
While the rest of the group fight for survival, Axel and Scarlett defend a mountain stronghold against a relentless foe; Doc makes a medical discovery that could change everything.
A mystery unravels when an organization fighting to find a cure for vampirism enlists the help of someone in the group; old loyalties are put to the test with deadly results.
Vanessa's past rushes back to confront her in an unexpected way; a secret is revealed that Doc has been protecting; in a bid to bolster his power, Dmitri sends Scab on an impossible mission.
As the sisters prepare to open the portal to the Dark One, Hansen makes the ultimate sacrifice.
Vanessa faces off with Dmitri; Axel fights against becoming a full-fledged vampire; Sam tracks Mohamad, Flesh and Lucky; Scab tries to enlist a fierce group of vampires to join Dmitri.
Vanessa relives the memories of her ancestor, Lily Van Helsing, in Colonial Hong Kong. There, she learns to control her dark side and fights the B'ah, the second vampire Elder.
A tense standoff between law enforcement and the survivors erupts into a bloodbath; in a bid to evade a vicious breed of vampire, Axel and Scarlett find themselves hunted like prey.
Now in Dmitri and Rebecca's clutches, Vanessa learns secrets from her past and finds herself at a crossroads; Flesh and the Resistance accelerate their timeline to rescue Vanessa; Mohamad and Sheema finally come to blows over their allegiances.
Scarlett is reunited with Axel but he is badly injured before they can find Vanessa. A mysterious man helps them find their way. Flesh and Jolene are fugitives on the run from Blaktek.
Vanessa, Axel, Jack, Violet and Ivory finally reunite in the real world and begin their plan to take down The Dark One.
Vanessa is once again resurrected and must confront her family's legacy; Axel, Scarlett and the others fend off Blak Tek's forces, who hope to add Scarlett to their list of lab rats.
To find its totem, the First Elder brings Vanessa, Scarlett and Axel to an abandoned insane asylum protected by powerful vampires, where they discover the legacy of a long dead Van Helsing relative.
Vanessa encounters a group of vampires whose gruesome methods bring savagery to a new level; the Juvenile Delinquents continue their game of cat and mouse with Sam and that has deadly consequences.
Doc and Jolene clash with Denver authorities over the repellent. Flesh chooses to face his past. Axel struggles with leaving Scarlett behind. Ivory and the Sisterhood infiltrate Denver.
Vanessa has a final showdown with the Second Elder in San Francisco. In Denver, Flesh, Doc, Julius and Jolene learn that even in a Safe-Zone, life isn't easy.
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