Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital surgical unit. Alone in the world and unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.
Lim is challenged by the unique circumstances surrounding a pregnant patient with an aggressive tumor. After misdiagnosing a patient, Claire makes a disconcerting discovery about certain practices at the hospital.
Drs. Lim, Park and Wolke treat a woman with Valley fever and discover a secret she has been hiding from her fiancé. Meanwhile, Drs. Murphy, Allen and Andrews treat a 45-year-old virgin and help her make a big decision about her life.
Now that Shaun has called off the wedding, he is forced to confront Lea about their relationship and determine what he really means to her. Meanwhile, the team debate their opinions on plastic surgery and Dr. Audrey Lim hopes to expose Salen’s cover-up over an infant’s death to take her down before it is too late.
Sophie takes Lea out for a day full of luxurious wedding planning. And after a near fatal oversight, Dr. Lim senses an underlying issue is behind nurse Villanueva’s unprofessional behavior.
Dr. Shaun Murphy unknowingly creates a competition between Drs. Danica Powell and Daniel Perez when he introduces a new performance rating system. Meanwhile, Dr. Morgan Reznick may have crossed a line with Dr. Alex Park.
While Drs. Lim, Murphy and Wolke help a teenage “biohacker” whose self- experiments begin to compromise his health, Drs. Morgan, Park, Jordan and Glassman treat a young woman who wants a controversial surgery to treat her depression and chronic pain. Additionally, Dr. Reznick looks to take the next step in her relationship with Dr. Park.
When someone mistakenly brings a hallucinogen-laced dish to the hospital’s company potluck, much of the hospital staff and doctors are incapacitated — leaving doctors Murphy, Glassman and Allen forced to take on all the hospital’s cases, further exacerbating Dr. Murphy and Dr. Glassman’s conflicting work styles.
While Doctor Andrews treats a foster kid for injuries sustained at his group home, Shaun and team look to Lea’s expertise with cars and auto repair to help a patient whose iron lung has broken. Meanwhile, the patient’s niece, a documentarian, takes an interest in Shaun.
Park and Shaun treat an elderly Asian man brought to St. Bonaventure by his daughter after being the victim of a hate crime. Lea goes behind Shaun’s back to help raise his negative patient satisfaction scores.
Dr. Shaun Murphy and the team race to save a pregnant woman's baby and find her current situation as a convicted felon complicates it even more than they realize. Meanwhile, the hospital takes on some unexpected changes that the staff are not prepared for.
The team treats a famous marriage counselor after she injures her ankle from falling, but when she offers relationship advice to them, Dr. Morgan Reznick quickly spots that their patient might be experiencing something far more serious. Meanwhile, Dr. Audrey Lim is determined to get to the bottom of what really happened in the OR during her surgery and sets off on her own internal investigation.
After finding out the gender of their unborn child, Lea's enthusiasm prompts Shaun to make an effort to be a more supportive partner. The team treats a navy pilot whose previous doctor's misdiagnosis compromises her chances at a full recovery.
Claire is blindsided when her absentee father shows up at her door. Shaun feels disconnected from Lea, causing tension in their relationship.
Shaun and Lea go on a camping trip to distract themselves from their grief over their miscarriage. Meanwhile, Morgan and Park argue about the best course of treatment for their patient.
The team operates on a military reenactor whose attempt at authenticity has created an explosive predicament that even Dr. Shaun Murphy couldn’t predict. Meanwhile, Dr. Jordan Allen and Dr. Daniel Perez are on a race against time as they search for a severed foot.
Shaun and Lea’s upcoming engagement party has everyone in a festive mood after their return from Guatemala. Meanwhile, a young single mother learns her son may have contracted his cancer from a surprising source, and Mateo finds out if his previous issues in America will be resolved.
With several candidates vying for residency at St. Bonaventure, Chief of Surgery Dr. Audrey Lim tasks Dr. Shaun Murphy, Dr. Claire Browne and Dr. Alex Park with mentoring the top first-year resident contenders. As their mentees shadow them for the day, Shaun and Park meet with Andrews to discuss a difficult surgery scheduled for a minor. Later, Shaun inadvertently insults Lea while discussing the pros and cons of the controversial surgery. And elsewhere, Dr. Morgan Reznick seeks out Claire and Lim's help on a consult.
In the midst of a heatwave, Dr. Shaun Murphy and Dr. Danica Powell are at odds when it comes to their patient’s surgery. Their heated stalemate tests Shaun’s patience and his willingness to compromise. Meanwhile, when the hospital loses power, Lea and Dr. Aaron Glassman are forced to come up with a quick solution or risk a total shutdown that could risk patients’ lives.
As Dr. Lim struggles to cope with the residual emotional trauma of COVID-19, she encounters a young war veteran fighting debilitating PTSD. After discussing his case with the team, Claire suggests a radical treatment to help him. Still reeling from the recent loss of his mentee’s patient, Shaun declares he doesn’t want to teach the new residents anymore. An eccentric patient keeps the team entertained.
The team travels to Guatemala on a mission to help patients at a rural hospital. The team faces a small community that is in desperate need of help, but they must identify who they can help most. Lea is still struggling with the loss of her baby.
When a woman pregnant with sextuplets arrives at the hospital, Dr. Marcus Andrews must split the doctors into teams to ensure their health and safety following their high-risk delivery. Meanwhile, Shaun and Lea must face their own hurdles as they discuss starting a family.
Shaun and the team treat a young girl whose father’s personal research complicates their treatment plans. Park, Reznick and Lim’s patient refuses a life-saving lung transplant despite having a family donor.
Salen takes extreme measures when she learns that the surgical staff have joined Lim's efforts against her. The team treats a liver transplant patient whose organ donor unwittingly gave him cancer.
Claire and the team must face hard truths about what lines they are willing to cross when one of Claire's idols becomes her patient.
Dr. Shaun Murphy and the team try to get a better understanding of COVID-19; Claire looks for a way to grieve Melendez's death through her patients; Dr. Alex Park and Mia discuss their future together.
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