A humorous look at newlyweds Jamie and Paul Buchman as they discover each other's idiosyncrasies and learn to deal with them. Paul, a documentary filmmaker, is creative, idealistic and an all around nice guy. Jamie, a public relations specialist, is direct, assertive and a practical person. They are very much in love this helps them develop a strong relationship in spite of their friends, families and themselves.
Paul and Jamie try to plan a surprise birthday party for Mabel while she intends to reveal a big surprise of her own.
When Paul and Jamie drop their daughter Mabel off for her first day of college, it quickly becomes clear that they have very different ideas of what their lives after children will look like.
After too many surprise dorm visits, Mabel forces Jamie to sign a contract limiting contact for the next 48 hours, and suddenly Paul finds himself in the parenting hot seat.
Jamie makes the decision to get back into the work force, but time and menopause conspire against her. Meanwhile, Paul is invited to speak to Mabel’s class only after promising to Mabel that no one will know they’re related.
Jamie spins out when one of her meticulously crafted scrapbooks documenting Mabel’s childhood disappears. Meanwhile, Ira shocks everyone (himself included) when he asks Lucia to marry him.
Tonya oversees Jamie’s sessions as she transitions back into the workplace as a therapist. At the gym, Paul is going through a battle of his own as Mark is upset that Paul refuses to be naked around him.
Paul and Jamie pay a visit to the retirement home to visit Paul’s mother, Sylvia, and her new boyfriend, Ralph. Meanwhile, an unexpected visitor walks into Ira’s restaurant.
Paul and Jamie's concerns about mortality and getting their affairs in order are triggered when they attend the funeral of Paul and Ira's Childhood friend.
When Lisa is double-booked on her celebrity pet-sitting obligations, Jamie volunteers Paul to stay at Anderson Cooper's place, allowing him his first bachelor night in years.
Paul and Jamie are forced to make a tough decision about the future of their home when a wealthy buyer expresses interest in their apartment.
Following Sheila's advice, Paul and Jamie head to a marriage boot camp in the Berkshires in hopes of working out their issues.
Paul and Jamie help Mabel deal with the fallout after a school experiment goes awry; Jaime stumbles upon an unconventional way Tonya can help Donovan overcome his sleepless nights.
Having chosen the residents of Apartment 11-D as its parents, the baby in the making deals with musical interludes and parental cooing, and with lots and lots of choice moments from their years together. In other words, a clip show.
Sheila declares Paul and Jamie cured. However, Murray is still traumatized by the earlier puma attack, so Paul and Jamie enter him in a dog show.
Ira finds a note in some old pants that remind him of a date made twenty years ago but he doesn't remember with whom. Paul and Jamie steal Burt's decrepit car so they can ditch it, since he won't sell it.
Jamie's dress is ruined by a dry cleaner who is unwilling to make restitution. Paul has a dream where Einstein gives him a partial solution to the millennium bug. He needs to have the dream again, so he can get the rest of the solution.
The couple learns that Jamie will be in bed with Mark McGwire via virtual reality.
Paul and Jamie discover the extra comfort of sleeping apart. Marvin is wrestling part time and Ira becomes his manager.
Uncle Phil goes back to high school. Lisa gets breast implants.
Paul accidentally runs over Jamie's mother. While she is in the hospital, her estranged husband visits.
When Debbie compiles Buchman and Stemple family trees, she learns that Paul and Jamie are actually cousins.
Paul and Jamie act as matchmakers for dogwalker Nat and babysitter Arley. Meanwhile, Ira tries giving up sex, and Paul makes a discovery about Jamie when they go to a sleep clinic.
Mr. Wicker goes out of town and asks Paul and Jamie to tend his rooftop garden. Mabel loves another baby's rare toy.
Paul, Jamie and Ira decide to make a baby video. However, Paul starring as the Sandman frightens kids and turns them off to the concept. Meanwhile, Paul's parents tell him he has a half-brother.
Paul and Jamie search for a full-time nanny, and Paul finds one in the form of Nancy Bloom, a caterer he inadvertently got fired from the production of a documentary about “The Making of Titanic.”
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