MacGyver follows the adventures of the laid-back, extremely resourceful secret agent Angus MacGyver. He prefers non-violent conflict resolution whenever possible and refuses to carry or use a gun.
An archaeologist friend pays MacGyver a visit to get his help in using a map to find an ancient artifact called the Holy Rose.
MacGyver and his archaeologist friend continue on to London and France in their search for the Holy Rose. Along the way they come across a notorious jewel magnate who has deadly intentions.
Dr. Zito returns to menace MacGyver and Murphy when he escapes after his latest sanity hearing, leaving a series of nasty clues designed to give Mac a crash course in evil.
MacGyver organizes a gambling sting operation in order to catch the murderer of a horse trainer, a money launderer for a Cuban drug lord.
MacGyver helps an Amish family, who saved his life, from having their farm seized by the government.
MacGyver is forced to work with a ruthless freelance agent to rescue a human rights activist who is being held in a psychiatric hospital in Czechoslovakia. The rescue is an apparent success, until the secret police then kidnap the activist's wife to get him back.
MacGyver trails a friend, Billy Colton, to Africa where he witnesses the cruel slaughter of the endangered Black Rhino. When he joins the activists, hoping to prevent the poaching, Mac meets up with the men behind the scheme - Ladysmith.
When the head of a American-Chinese shipping company is attacked in his office by a killer, MacGyver and the man's grandson—who is heir to the company—must find out who was behind the attempt on his life.
After his sister dies in an avalanche, Murdoc decides to resume working for his former employer, HIT. In order to regain their trust, he has to take on MacGyver once again.
An inner city youth club is threatened when a black resident is framed for auto theft by a neighborhood racist who'll stop at nothing to close the center—even murder.
Mac and a bounty hunter join forces with a bulldog named Frog to track down a Bulgarian defector who was the accidental witness at a murder and who is now being stalked by the killer, who needs a map she doesn't know she possesses.
Mac and Nikki race to recover equipment from a downed experimental plane before the Soviets, who are using a psychic to guide them to the wreckage.
MacGyver risks judicial displeasure when he breaks jury sequester to investigate the scene of a racially charged murder, and discovers evidence that drastically alters the interpretation of the facts.
MacGyver accompanies his friend Penny Parker to an old house she has inherited from her Aunt Betty, who mysteriously died 30 years before. When strange things start happening, Penny is sure that the house is haunted. However, MacGyver tries to convince her that there's no such thing as ghosts, but then he starts witnessing the strange events, too.
MacGyver teams up with colleague Nikki Carpenter to find out who is behind the attempts on her life. When they find out that the man who tried to kill her is connected to two terrorists who blew up a local post office, MacGyver and Nikki must find out what the terrorist's next target is before it's too late.
MacGyver heads up a trip with four other Phoenix Foundation employees into the wilderness as part of a stress reduction program. After discovering that a prison bus accident has freed several prisoners, the employees begin to question each other's behavior. MacGyver must now figure out which man, if any, is not to be trusted before it's too late.
While retrieving tickets for a hockey game at the Phoenix Foundation, MacGyver and his grandpa Harry get caught in the middle of a woman's plot to blow up the building using a bomb that she herself made. They try to escape, but are locked in. Now they must figure another way out before she activates the bomb.
Mac uncovers an out-of-this-world scam when he investigates some mysterious indentations in a farmer's field.
The Phoenix Foundation's purchase of a Nazi art treasure leads Mac to a holocaust survivor who claims family ownership of the painting, and to a group working to create their own ‘Aryan nation.’
MacGyver tries to help an old friend who believes her jealous twin sister is trying to kill her.
While testing a new nuclear bomb defusing team at the Phoenix Foundation, a deadly explosion kills three men. Pete blames himself for not inspecting their equipment better and resigns from his job out of guilt. However, Pete is replaced by a not-so-trustworthy man—one who may have been connected to the explosion.
Mac and Jack return from a flight to find an abandoned baby in Jack's hangar, complete with a desperate note from the mother and his own endowment fund hidden in his diapers.
A retired actor and his wife stop at a motel on the way to Los Angeles. MacGyver rescues them from a drunkard who nearly makes a mark on their car. MacGyver is supposed to meet a mobster-turned-informant at the motel, but the meeting goes wrong. The mob shows up and kills MacGyver's friend before he can give MacGyver what he promised. Instead the bag lands in the old couple's car, where the old actor finds it and discovers it full of money.
Renegade America service men steal everything that's not nailed down in Thailand, creating a life-threatening situation. MacGyver helps set things right, while helping an old friend get acquainted with a son he never knew he had.
A mysterious person, who calls himself "Viking", has just bombed a cruise ship. He demands six million dollars or another bomb will go off within hours. So MacGyver, with an old friend from Vietnam, Charlie Robinson, is sent to disarm it. But when they get there, they find out there's more then one bomb on the ship.
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