The BEST episodes of How to Change Your Mind

Every episode of How to Change Your Mind ever, ranked from best to worst by thousands of votes from fans of the show. The best episodes of How to Change Your Mind!

A four-part documentary series based on Michael Pollan's book of the same name, exploring psychedelic substances and what they can teach people about consciousness, dying, addiction, depression and transcendence.

Last Updated: 3/3/2026Network: NetflixStatus: Ended

7.46

74 votes

#1 - Chapter 2: Psilocybin

Season 1 - Episode 2 - Aired 7/12/2022

Magic mushrooms, long considered sacred by the Indigenous Mazatec in Mexico, have recently become the subject of scientific studies exploring their potential to treat mental illness.

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7.42

88 votes

#2 - Chapter 1: LSD

Season 1 - Episode 1 - Aired 7/12/2022

From its 1943 origins to today's microdosing trend, LSD has been expanding minds and changing lives with the help of counterculture gurus — and the CIA.

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7.40

57 votes

#3 - Chapter 3: MDMA

Season 1 - Episode 3 - Aired 7/12/2022

Championed by both therapists and ravers, ecstasy stands out as the first psychedelic likely to be approved by the FDA as medicine, thanks to passionate advocates and its value as a treatment for PTSD.

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7.21

52 votes

#4 - Chapter 4: Mescaline

Season 1 - Episode 4 - Aired 7/12/2022

Mescaline is the psychoactive molecule found in San Pedro and peyote cacti. Native Americans have had to fight for legal access to these traditional sacred medicines and take them in religious ceremonies, experiencing powerful healing from struggles like addictions and trauma.

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