The BEST episodes of Hamilton's Pharmacopeia

Every episode of Hamilton's Pharmacopeia ever, ranked from best to worst by thousands of votes from fans of the show. The best episodes of Hamilton's Pharmacopeia!

Hamilton is fascinated by drugs. Join him on an inedible journey as he investigates the history, chemistry, and social impact of the world's most extraordinary mind-altering substances.

Last Updated: 1/4/2023Network:VICE TV (US)
The Psychedelic Toad
43 votes

#1 - The Psychedelic Toad

Season 2 - Episode 1 - Aired 11/28/2017

Hamilton embarks on a quest to answer the most important question in ethnoherpetological history and along the way, he finds the power of love.

Watch Now:AmazoniTunes
A Clandestine Chemist's Tale
33 votes

#2 - A Clandestine Chemist's Tale

Season 2 - Episode 6 - Aired 1/2/2018

Hamilton meets an unsung hero of the psychedelic underground and hears a tragic tale of MDMA synthesis and chemiluminescence.

Watch Now:AmazoniTunes
Ketamine: Realms and Realities
35 votes

#3 - Ketamine: Realms and Realities

Season 2 - Episode 5 - Aired 12/26/2017

Hamilton heads to India to see industrial Ketamine synthesis, and speak with therapists and luminaries in an attempt to understand the role of dissociative anesthetics in society.

Watch Now:AmazoniTunes
Shepherdess: The Story of Salvia Divinorium
67 votes

#4 - Shepherdess: The Story of Salvia Divinorium

Season 1 - Episode 3 - Aired 11/9/2016

From the heavenly cloud forests of Oaxaca to a viral video of Miley Cyrus, Hamilton investigates the inconspicuous yet extraordinary psychedelic plant Salvia divinorum.

Watch Now:iTunes
Synthetic Toad Venom Machine
17 votes

#5 - Synthetic Toad Venom Machine

Season 3 - Episode 1 - Aired 1/4/2021

Haunted by past mistakes, Hamilton embarks on a journey to correct an error in his reporting and identifies the origin of an international toad venom smoking phenomenon.

Watch Now:AmazoniTunes
The Lazy Lizard School of Hedonism
59 votes

#6 - The Lazy Lizard School of Hedonism

Season 1 - Episode 6 - Aired 12/7/2016

In our last episode, we meet with famed LSD chemist Casey Hardison in the Nevada desert and embark on a road trip to visit an unsung hero of psychedelic history - Darrell Lemaire.

Watch Now:AmazoniTunes
Wizards of DMT
46 votes

#7 - Wizards of DMT

Season 2 - Episode 4 - Aired 12/19/2017

Hamilton travels across North America to study how and why DMT exists in the environment and the laboratory.

Watch Now:AmazoniTunes
Kratom: The Forbidden Leaf
38 votes

#8 - Kratom: The Forbidden Leaf

Season 2 - Episode 3 - Aired 12/12/2017

Hamilton investigates the pharmacology and traditional uses of Kratom, a Thai tree with opioid-containing leaves.

Watch Now:AmazoniTunes
Peyote: The Divine Messenger
42 votes

#9 - Peyote: The Divine Messenger

Season 2 - Episode 2 - Aired 12/5/2017

From the greenhouses of Thai cactophiles to the Tamaulipan thornscrub, Hamilton traces the history of peyote with the help of a Native American peyotist.

Watch Now:AmazoniTunes
Fish N' Trips
40 votes

#10 - Fish N' Trips

Season 1 - Episode 5 - Aired 11/30/2016

Hamilton embarks on an aquatic adventure to Reunion Island and Madagascar to investigate ichthyoallyeinotoxism and a twisted history of hallucinogenic fish.

Watch Now:iTunes
Magic Mushrooms in Mexico
63 votes

#11 - Magic Mushrooms in Mexico

Season 1 - Episode 4 - Aired 11/16/2016

From the Aztec empire to the underground laboratory, Hamilton explores magic mushrooms with the help of shamans, clandestine growers, and ethnomycologists.

Watch Now:AmazoniTunes
A Fungal Fairy Tale
30 votes

#12 - A Fungal Fairy Tale

Season 2 - Episode 7 - Aired 1/9/2018

Hamilton ascends the Carpathian Mountains, microscope in hand, to learn how Europeans use Amanita muscaria, and uncovers the chemistry behind a mushroom-inspired pharmaceutical.

Watch Now:AmazoniTunes
A Positive PCP Story
68 votes

#13 - A Positive PCP Story

Season 1 - Episode 2 - Aired 11/2/2016

Hamilton travels across the USA meeting with addicts, dealers, and chemists to trace the history of PCP from its pharmaceutical origins to its escape onto the streets.

Watch Now:AmazoniTunes
A Positive Methamphetamine Story
20 votes

#14 - A Positive Methamphetamine Story

Season 3 - Episode 2 - Aired 1/11/2021

From X-ray crystallography to vesicular dopamine release, Hamilton travels the country visiting meth labs to understand the process behind a great American folk art.

Watch Now:AmazoniTunes
The Story of the South African Quaalude
81 votes

#15 - The Story of the South African Quaalude

Season 1 - Episode 1 - Aired 10/26/2016

South Africa is the last place on earth Quaaludes can still be found. Hamilton travels there to study the drug and finds a dark history of medical experimentation.

Watch Now:AmazoniTunes
The Cactus Apprentice
24 votes

#16 - The Cactus Apprentice

Season 2 - Episode 8 - Aired 1/16/2018

Deep in the Andean highlands of Peru, Hamilton becomes the apprentice of a local shaman, learning how to use the night-blooming San Pedro cactus as a medicine.

Watch Now:AmazoniTunes
Bufotenine: In Search of Hataj
19 votes

#17 - Bufotenine: In Search of Hataj

Season 3 - Episode 5 - Aired 2/1/2021

Succumbing to viewer requests, Hamilton journeys to South America to understand the legend of Bufotenine, the world's oldest psychedelic.

Watch Now:AmazoniTunes
Xenon: the Perfect Anesthetic?
16 votes

#18 - Xenon: the Perfect Anesthetic?

Season 3 - Episode 3 - Aired 1/18/2021

Hamilton traces the multibillion year history of nitrous oxide on Earth and follows the strangest noble gas to the Czech Republic.

Watch Now:AmazoniTunes
Synthetic Ibogaine: Natural Tramadol
21 votes

#19 - Synthetic Ibogaine: Natural Tramadol

Season 3 - Episode 4 - Aired 1/25/2021

After revealing a scientific mystery around Tramadol-addicted cows in West Africa, Hamilton follows a Gabonese opiate addict to a psychedelic ritual.

Watch Now:AmazoniTunes
Ultra LSD
20 votes

#20 - Ultra LSD

Season 3 - Episode 6 - Aired 2/8/2021

With the precise structure of LSD's molecular target identified, Hamilton discusses the new era of psychedelic research and meets pioneers of the field.

Watch Now:AmazoniTunes

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