Frontier hero Daniel Boone conducts surveys and expeditions around Boonesborough, running into both friendly and hostile Indians, just before and during the Revolutionary War.
A former slave (Yaphet Kotto), adopted by Indians, terrorizes and robs Boonesborough.
Boone assists a boy hanging by his feet from a tree (Kurt Russell) and winds up at the mercy of a larcenous clan; guests Lloyd Nolan, Lane Bradford.
Timothy Patrick Bryan shows up in Boonesborough looking for his long lost daughter, Rebecca Boone. Rebecca wants nothing to do with the man because he abandoned her family when she was a child.
An orphan (Kurt Russell), determined to keep his family together, causes trouble for rescuer Boone.
After returning from a trip to Virginia, Daniel and Mingo tell via flashback how they met the legendary Benjamin Franklin and almost got themselves shanghaied to England in the process.
Boone pursues a runaway slave (Rafer Johnson) stealing pelts to earn passage to Africa; guest Michael Conrad.
A slavehunter (James Gregory) chains Boone with a group of escaped slaves then is attacked by Shawnee.
Superstition runs rampant in Boonesborough when two mysterious travelers arrive and are followed by the appearance of a deadly panther.
A chief (Henry Silva) of a long-dead Aztec tribe enters the Shawnees Valley of Death; guest Simon Oakland.
Jericho Jones kidnaps a Creek princess and elopes with her. Needless to say, this event causes considerable disruption of settler-Native American relations.
Israel accidentally startles a passing peddler's horse and his goods are ruined. Daniel agrees to compensate Seth Jannings for his loss, but matters are complicated when Jannings steals a sacred mourning doll from the wife of a Native American chief and plans to hold it for ransom. Knowing that this could lead to major hostilities with the Native Americans, Daniel puts his own neck on the line to retrieve the doll from Jannings.
Boone befriends a mother (Geraldine Brooks) and son (Kurt Russell), but learns the woman is accused of witchcraft.
While hunting, the Boones meet a delirious British officer (Macdonald Carey) pursued by vengeful Shawnees.
Lacking water and powder, the women and children of Boonesborough seem easy prey for attacking Choctaws.
Boone commands four criminals recruited by Yadkin to haul frieght to Boonesborough; guests Sean McClory, Gordon Jump.
British soldiers and Indians surround Jemima as she tries to help Boone, wounded in the wilderness.
Daniel receives a major surprise upon his return from a journey when British Colonel Worthing orders Boonesborough to be evacuated. He says it's because he's battling a Native American rebellion but Daniel suspects otherwise.
Israel becomes lost in the woods after fur thieves ambush him, Boone and Yadkin.
Boone cannot believe a boyhood friend (Pat Hingle) murdered three Cherokee youths.
Boone faces a killer bear and the man (Slim Pickens) who has sworn vengeance on the animal; guest Dick Foran.
Yadkin's trickery leaves Boone the unexpected, and unwilling, owner of indentured Irish sisters (Fay Spain, Nina Shipman).
An idealistic schoolteacher (George Gobel) incites Boonesborough's wrath by giving gunpowder to the Shawnees.
A Shawnee prophet (John Russell) predicts massacre for the settlers of Boonesborough; guest Patricia Huston.
A dream about a man whom Daniel thought was dead is followed by the appearance of three men at his door demanding that he take them to the site of a bloody Native American massacre.