Fun-loving San Francisco Police Department investigator Nash Bridges is part of the elite Special Investigations Unit. He tackles crime using his keen sense of humor and charm. Joe Dominguez comes out of retirement to become Bridges' wisecracking yet more rule-abiding partner.
Nash and the SIU discover the Cell Phone Killer's intentions are to kill his doctor. Lonely Joe keeps having erotic dreams about Caitlin. Evan gets fired from his bartender job.
Nash and Joe help a Canadian Mountie track down a ring of poachers who are illegally selling bear gallbladders, which are supposedly valuable as medicine and as an aphrodisiac; Rachel fears she may be pregnant.
Nash and the SIU uncover a counterfeitering group where the money is top-of-the-line Supernote quality. Moving in to bust the group, they discover a fake SIU gang impersonating the police. Cooperation becomes tense as suspicions abound over who and what to trust. In the interim, as Nick gets in over his head financially with his horse costs, Nash reluctantly agrees to work with Joe on an off-duty case searching for a Super Bowl ring. However, Nash and Joe soon find themselves impersonating a gay couple as the case develops differently than Nash anticipated.
Nash and Joe cut a deal with Carlos Casas, a gangland money launderer, offering him a new identity in exchange for his testimony.
Nash's sister, Stacy, is robbed, forcing her to come out of the closet as a lesbian. Nash deals with his own secret romance with Nick's nurse Whitney. The fallout from these family revelations takes place while Nash tracks down a kinky couple responsible for the robberies.
Nash and Joe have a task of escorting a secret key witness from the Witness Protection Program to San Francisco to testify in an important SIU-related case. They fall under gunfire. Nash realizes there's a leak somewhere on the prosecution's team. He enlists the help of Stacy to protect them until he can solve who it is and get the witness safely to San Francisco. Cassidy is stood up for a date and decides to go out with J.J. instead.
Nash and Joe investigate a missing hockey goalie connected to the Russian Mafia with the help of kidnapper Tony B., who has lost all memory of the crime. Joe visits a fertility clinic when Inger decides she wants another child. Harvey and Evan shoot off the roof of the watch commander's brand new squad car and must get it fixed before he finds out.
After Cassidy is hit in the behind by a stray bullet at school, Nash and Joe go on the hunt for the shooter and the dealer who's putting guns into kid's hands. Due to earthquake repairs on his apartment, Nash and Nick have to take up residence with Lisa for a few days. It's here that Nash meets Freddie, the apple of Cassidy's eye, the pain in Nash's behind, and learns that Cassidy's decided not to go to college.
Nash busts computer hacker/robber, Andy, and discovers Andy's committed the crime because his wife has been kidnapped. The crew of crooks want Andy's hacker skills as their ransom. The SIU must work to save the woman and bring down the crew before their daring daytime robbery is successful. Meanwhile, Nash and Whitney finally consummate their relationship.
It's Christmas Eve, and Nash and his fellow cops are trapped at the SIU as they wrap up a murder investigation and a prostitution case. Joe borrows Nash's 'Cuda to get it detailed and freaks out when the car is stolen; Nash's personal gifts to Lisa and Whitney get mixed-up; personal crises abound as the cops deal with the Christmas holiday.
When a controversial Latina actress is shot and killed, suspicion turns first to her former lover, then to a crazed stalker. Evan comes back to work after surgery, but Cassidy wants nothing to do with him. Caitlin moves in with Nash, and causes strife between her and Nick.
Nash and Joe discover that someone is using their detective agency's name to stir up business for themselves, and that one of the impostor's clients is out to kill Nash. Survivor stars from the original season guest star (Dirk Been, Joel Klug, Gervase Peterson, Sean Kennif & Jenny Lewis)
Nash and Joe have to babysit Mickey Tripp (Paul Gleason), a motormouth shockjock, after a body armor-wearing assassin tries to kill him. Their search for the assassin is compounded by the fact that Nick has hired them on an off-duty case to find his softball team's star pitcher - a Salvadoran defector named Chus (Jose Canseco), who's on the run from the INS (Karl Malone). Caitlin babysits her roommate's kids.
Nash and Joe help FBI Special Agent Katz recover a Suburban full of stolen FBI weapons. Joes sets Nash up on a blind date with his nanny.
Nash follows the trail of James and Lorraine, a thrill-seeking couple on a wild crime spree in San Francisco. Nash feels personally responsible for the fate of Lorraine when he discovers she is the daughter of a volatile SFPD Inspector. Nash's interaction with the young fugitive color his relations with Cassidy, who's semi-nude photo is splashed all over town in a racy safer sex poster.
Joe goes undercover inside State Prison to bring down a ruthless Mexican gang leader who put out a hit (from behind bars) on a SFPD undercover cop who had infiltrated the Mexican Mafia. Nash runs the investigation on the outside, hoping to fulfill a promise to the dead man's widow by catching the trigger man. Naturally he'll have to overcome the distraction caused by Nick, putting together his will, who discovers some long-forgotten wealth.
A small time getaway driver sets up two robbery gangs to rob each other, while he walks away with the loot and complete immunity. Evan is brought in for another chance in Joe's off-duty case concerning a kidnapped son who has had a gender change. The 'Cuda hood is graffitied, and Nash puts Boz Bishop on the case.
Nash Bridges and the SIU team respond to a bomb threat against Mayor Bobbie Werksman. In a tenement, they find the bomb, but accidently trigger the timer. Everyone rushes out in time as the bomb destroys the building. Nash is the last one to leave.
Nash, while investigating an apparent gang killing, discovers that the weapon used for the job is the Army's newly missing man-portable, antitank system: The Javelin. Nash is assisted in the investigation by Sandra McCormick whoose career is on the line if the Javelin is not recovered.
Nash has to deal with the fact that Joe may have 72 hours to live after being exposed to a deadly virus while Nash & Joe investigate a drug theft from a research lab.
A million dollar bounty on Nash's head triggers an onslaught of attacks by a series of ultimate fighters. Michelle meets ""Mr. Right"" while on a stake out trying to trackdown an Internet rapist. Nash is convinced Cassidy's new boyfriend in gay.
A sleep-deprived Nash must track down an ingenious bomber targeting a corporation he feels has wronged him. Cassidy tries to conceal her nudity in a school play.
A nurse who assists a plastic surgeon for the mob is murdered because she stole the before and after photos of altered mobsters. She passes a key to the hidden files to Joe, and Joe becomes a target of mobster Louis Fallon. Nick appears with Cassidy in her play, but suffers a bout of Alzheimer's. Harvey meets a new girl, but she is a former lesbian.
On the way to an undercover purchase of some heavy industrial equipment from some Russian gangsters, carrying $300,000 of the city's money, Inspector Harvey Leek vanishes. Has there been foul play? Or has Harvey pocketed the money? Nash Bridges has to find him before it's too late.