Mission Hill revolves around Andy French, a 24-year-old charmingly lazy guy, and his nerdy teenage brother Kevin who moves into Andy's big city loft. These two couldn't be more opposite: Andy can never seem to settle on a particular job or girlfriend, while straight-A Kevin never gets a B or a girlfriend. The show takes place in the fictional city of Cosmopolis's equally fictional neighborhood of Mission Hill. It's a hip place full of diverse, colorful characters -- think Silver Lake in Los Angeles, Wicker Park in Chicago or Williamsburg in Brooklyn. Regulars also include Posey Tyler, the whimsical roommate who hides a secret dark side, and Andy's mellow best friend Jim Kuback who's well-connected to the hip downtown scene. Across the hall are Natalie, Carlos and their baby, who are, respectively, a painter, a professor, and an infant. Next door are Gus and Wally, a gay couple in their 60s given to loud fights and loud making up.
Kevin, Toby and George seek to cheat on their SATs. Meanwhile, Posey goes into business as a masseuse, but her poorly-worded ad doesn't land her the kind of customers she was hoping for.
Andy's parents stick his nerdy, little brother, Kevin, on him -- which poses quite the threat to Andy's slacker lifestyle. Meanwhile, Kevin is torn between his desire to rat on Andy and his desire to cease being a nerd.
Andy signs up for The Real World, planning to play the Puck character to show Mission Hill what a crock it all is, but once in the house, he finds himself under MTV's spell.
Andy is first pressured to go to Kevin's parent/teacher conferences, then is pressured to join the PTA by Toby's mother. During the whole ordeal, Andy has the hots for Kevin's teacher.
Kevin asks out the weirdest girl in his school, Eunice Eulmeyer, because she's the daughter of a well-known scientist, and he thinks the guy could write him a good letter of recommendation for college. Meanwhile, when Andy and company get refused entry into a new nightclub in town because they're not cool enough, they start up their own bogus nightclub -- and refuse to let the cool people into it.
Ron's shady dealings with the I.R.S. force the closing of the waterbed store. When Andy is unable to hold down a new job, Kevin goes to Ron in hopes of getting unemployment benefits for his brother.
Andy still hasn't found a job after two months -- not that he's exactly looking for one. His learning about Jim's previously secret career pushes him to become more motivated.
A teen starlet invites Andy to the Grammys. Meanwhile, Toby is "chased" by a rabid dog. And Posey decides to go on a spiritual journey to find nirvana. And we don't mean the music group.
Unable to handle rejection, Andy accepts Ron offer for assistant manager. Meanwhile, Stogie begins eating the living room couch when Andy neglects to buy dog food.
When Kevin is down in the dumps, Andy plans a big birthday party for him -- only Kevin isn't very grateful. Meanwhile, Carlos and Natalie get a new pet. A boa constrictor.
Kevin discovers that, before they were a couple, Gus directed Wally in a grade-Z science fiction film way back when -- which haunts Wally to this day.
Kevin is racked with guilt after he accidentally burns the local market while touching himself in its bathroom, and two of his mean classmates who were robbing the store at the time take the fall for it. Meanwhile, Jim inadvertently becomes a trendsetter when he returns from Japan wearing Day-Glo hot pants.