Hayate Ayasaki is an unlucky teenager who worked since childhood to make ends meet due to his parents' irresponsible behavior. One day he finds out that his parents ran away from home, leaving behind a massive gambling debt on his shoulders. While running away from the debt collectors, he ends up meeting Nagi Sanzen'in, a young girl who is the sole heir of the wealthy Sanzen'in estate, and due to a misunderstanding, Nagi ends up falling in love with Hayate. After he rescues Nagi from some kidnappers, she hires Hayate as her new butler. Aside from performing his ordinary duties as a butler, Hayate must fight to protect Nagi from harm, a difficult task as her life is always in danger because she is the target of other individuals coveting her family's fortune, and sometimes deal with some extravagant requests from her, oblivious to Nagi's true feelings for him.
Taking place after the events that occurred in Hayate no Gotoku! Can't Take My Eyes off You. Hayate, Nagi and Maria return to their daily lives at the Sanzenin Mansion and the Violet Mansion.
Hayate is still working as the Sanzenin Butler, and season 2 features a lot more Hinagiku, as scenarios that include herself and Hayate allude to potentially mutual feelings between them. Nagi is also interested in escalating her relationship with Hayate, since Nagi's perception of her relationship with Hayate remains based on the miscommunication that occurred on their first meeting.
Taking place one month after the events that occurred in the movie Heaven is a Place on Earth. Living at the Sanzenin Mansion once again, Nagi returns to her old ways of life, until she receives word from American authorities informing her that she has a week to pick up her late father's belongings that was indefinitely delayed due to various circumstances. After receiving news of her father whom she doesn't remember, Nagi then meets a mysterious girl (with a hidden agenda) claiming to be Nagi's little sister. The series tells a new story that is original to the anime and not directly based on the manga. The main author of the original series Kenjiro Hata personally created the original concept for the story of this anime.