Unit Chief Jack Garrett and his International Response Team (IRT), comprised of military hero and profiler Matt Simmons, brilliant tech analyst Russ “Monty” Montgomery and fearless medical examiner Mae Jarvis, are a specialized Division of the FBI tasked with solving crimes and coming to the rescue of Americans who find themselves in danger while abroad.
When the daughter of an American family visiting Haiti to adopt a child is kidnapped, the International Response Team travels to the island nation to try to find her. Also, Jack and his wife, Karen, prepare to send their daughter to college.
The International Response Team head to South Korea when an American college student is found disfigured. Meanwhile, Simmons fulfills his mother's dying wish to find his grandmother.
When American victims are found in different locations throughout Cuba, the International Response Team heads to the island nation to search for possible spree killers.
When an American girl leaves home to meet her boyfriend in Turkey, the International Response Team suspects she’s in trouble after being tricked by someone posing as her boyfriend.
When an American college student working in Johannesburg is killed and his brother goes missing, the International Response Team suspects a gang could be behind both. Jack works the case with Lieutenant Ananda Doshi, a profiler he’s worked with before who has an unorthodox style of investigation.
When an American man attending a festival in Mumbai wakes up missing a kidney and his friend gone, the International Response Team’s investigation leads them to suspect the UnSub is more than just trading organs on the Black Market.
When a woman vacationing in Mexico with her family is the victim of foul play, the International Response Team investigates her husband as the prime suspect when he flees.