FBI Agent Clarice Starling returns to the field in 1993, one year after the events of The Silence of the Lambs. Brilliant and vulnerable, Clarice's bravery gives her an inner light that draws monsters and madmen to her. However, her complex psychological makeup that comes from a challenging childhood empowers her to begin to find her voice while working in a man's world, as well as escape the family secrets that have haunted her throughout her life.
On the heels of ViCAP uncovering Alastor’s secrets, Clarice is imprisoned in an animal testing facility where she finds trafficked women being held captive. ViCAP and Ardelia team up to locate Clarice as she attempts to break from her captors in a race to rescue the other women.
As ViCAP finally gets the green light to raid Alastor Pharmaceuticals, Clarice punches another FBI agent in a moment of rage, then willingly turns in her badge and gun. Also, the rest of the ViCAP team uncovers the whole truth about the River Murders, and Clarice unwittingly puts herself in mortal danger.
In order to prove to Krendler and the VICAP team that she is fit for duty, Clarice must find the psychological key that will unlock a confession from the suspect in the three river murders.
Following the assassination of a suspect, Clarice and VICAP are investigated by Krendler’s rival at the Bureau, SA Anthony Herman. When Ardelia is recruited to assist him, it causes friction between the two friends.
Clarice zeroes in on the entity behind the River Murders, Alastor Pharmaceuticals. When Julia informs ViCAP of the impending sale of the company, ViCAP rushes to Alastor to prevent the purging of any incriminating evidence. Also, Clarice questions Alastor CEO Nils Hagen, who quickly changes the subject to Clarice's relationship with his son, Tyson.
Clarice and Ardelia team up to investigate a deeply twisted cold case after the body of a missing teenager is found entombed in concrete. Also, Clarice wrestles with the knowledge that Krendler may know the man who attacked her while she was held captive.
Catherine Martin escapes to Carneys Point, N.J., to confront Buffalo Bill’s mother. When Ruth recruits Krendler and ViCAP to track her down, Clarice volunteers to be the one to find Catherine before she commits a vile act and becomes a monster herself. Also, Julia continues to assist the ViCAP team's investigation despite the huge personal risk.
Clarice feels an emotional tie to the victim when ViCAP investigates what appears to be the suicide of a medical student in the United States on a foreign visa. Also, Krendler secretly collects a DNA sample from the man he suspects attacked Clarice at Woodhaven.
Sidelined because of her harrowing ordeal with Marilyn Felker, Clarice goes to Ruth Martin to be reinstated and gets roped into having dinner at the Martin residence. Clarice sees Catherine Martin for the first time since rescuing her from Buffalo Bill and must endure an uncomfortable evening with this fractured family. Also, Ardelia and the ViCAP team try to identify the man who aided Marilyn, but they hit a wall when they realize their DNA sample matches a file that's been erased from the Bureau's database.
A year after rescuing Catherine Martin from the horror of Buffalo Bill’s basement, FBI Agent Clarice Starling gets an urgent assignment from Catherine’s mother, Attorney General Ruth Martin, to join the Violent Criminal Apprehension Program (VICAP) in the investigation of three serial killings.
After ViCAP links the River Murders to a pharmaceutical company, Clarice seeks help from Julia Lawson, the corporate accountant for the company, who refuses to work with the FBI, and with Clarice specifically. Also, Catherine goes outside for the first time since her rescue from Buffalo Bill, and Ardelia and Agent Garrett connect with a lawyer they hope will take on the Black Coalition's case against the FBI.