The BEST episodes of 20/20 season 49

Every episode of 20/20 season 49, ranked from best to worst by thousands of votes from fans of the show. The best episodes of 20/20 season 49!

20/20 brings you hard-hitting investigative reports, news-maker interviews and compelling human interest and feature stories.

Last Updated: 10/22/2025Network: ABC (US)Status: Continuing
star
10.00
1 votes

#1 - Life on the Line

Season 49 - Episode 3 - Aired 10/10/2025

21-year-old mother Denise Amber Lee disappears from her North Port, Florida, home. Follow the real 911 calls as they unravel in this life-and-death case.

Watch Now:Amazon
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8.20
5 votes

#2 - He's Right Behind You

Season 49 - Episode 1 - Aired 9/26/2025

A family is stalked, leading to the murder of a mom. Dramatic body camera video captures the unfolding investigation.

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8.00
2 votes

#3 - What Happened to the McStays?

Season 49 - Episode 2 - Aired 10/3/2025

In 2010, Joseph and Summer McStay and their two young sons vanished from their Fallbrook, California, home. For nearly four years, the family’s fate remained unknown—until a grim discovery in the Mojave Desert turned the missing persons case into a homicide investigation.

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0.00
0 votes

#4 - Driven to Death

Season 49 - Episode 4 - Aired 10/17/2025

In Horry County, South Carolina, Gregory Rice's disappearance in early October 2020 sparked a search that eventually uncovered a secret affair.