Pinky and the Brain, those two genetically engineered lab mice, are homeless now that Acme Labs is no more. And the mice are in need of a place to hide as a secret organization wants to apprehend Brain. While hiding in a pet shop, the mice wound up getting bought by Elmyra Duff. Now the mice are forced to operate from Elmyra's house and endure her twisted ways of caring for animals. Despite all of these new complications, Pinky and the Brain still continue to try to take over the world.
When Elmyra takes a trip to Disneyland, The Brain plots to replace the theme song in the "It's A Small World" ride with his own hypnotic message.
Watch Now:AmazonBrain creates a formula that makes Elmyra's cat think that he is a dog.
Watch Now:AmazonIn his robot suit, Brain poses as "Patti Ann". The illusion is so convincing (not) that Elmyra's crush, Rudy, falls head over heels for him.
Watch Now:AmazonUsing an intergalactic radio Brain manages to flag down a passing alien, in hopes of trading for advanced weapons. Unfortunately the alien is driven away by an annoying Elmyra.
Watch Now:AmazonBrain builds the perfect science fair project for Elmyra, in hopes that she wins and brings home the prize money.
When Pinky dreams of living a normal family life Elmyra dresses up both he and Brain and places them in a doll house.
Watch Now:AmazonBrain reads an altered version of the Edgar Allen Poe poem The Raven.
Watch Now:AmazonChristmas episode. After Brain gets angry at Pinky and wishes that Pinky was never his friend, he has a dream that shows him what things would really be like without his life long pal.
Watch Now:AmazonElmyra runs for class president, though nobody expects her to win, but then no one knows that she has a secret advisor in The Brain...
Watch Now:AmazonWally Faust tries to steal Brain's latest invention and kill Brain once and for all.
Watch Now:AmazonBrain tries to make Elmyra popular, allowing him to work through her and take over the world.
Watch Now:AmazonThe mice must prevent discovery by The Circle when veterinarian wants to publicize Elmyra's bizarre cat/dog.
Watch Now:AmazonA teleportation device goes awry, fusing The Brain and Elmyra into a two-headed being.
Watch Now:AmazonWhen Rudy steals Brain's latest invention, Brain must get past a pet snake to retrieve it.
Watch Now:AmazonElmyra wants to go to the school dance with Rudy, but Rudy actually wants to go with Patty Ann, which is actually Brain in disguise. This suits Brain, because he needs to rescue his cologne that makes people instantly attractive.
Watch Now:AmazonBrain decides that he should organize the neighborhood kids into a gang, and when they grow up they will still see him as their leader.
Watch Now:AmazonWhen Elmyra enters a contest to be the first kid aboard the space shuttle, Brain coaches her in an attempt to win the contest.
Watch Now:AmazonPinky and the Brain get their own children's entertainment program.
Watch Now:AmazonBrain has a plan to clone dinosaurs but he needs funding to make it happen. Fortunately there is a cash prize for the spelling bee, and with Elmyra entered all he has to do is cheat to ensure she has even a slim hope of winning.
Watch Now:AmazonElmyra draws a cartoon that has Brain building a giant robot that wreaks havoc on France.
Watch Now:AmazonBrain tells Elmyra a bedtime story that closely follows the plot of Cinderella.
Watch Now:AmazonBrain builds a black hole in Elmyra's bedroom.
Watch Now:AmazonPinky, Elmyra and The Brain go to a Meat Festival. The Brain develops a plan to take over the world using "Meats of Evil".
Watch Now:AmazonVanity throws a party and Elmyra crashes it, with the help of Pinky and The Brain.
Watch Now:AmazonThe Brain becomes "Braino", a masked crime fighter, and an allusion to Zorro.
Watch Now:AmazonEpisode Ninja is a small business run by one person.
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