The story revolves around Nekoyama Suzu, a timid, shy tsundere girl loves dogs, and Inugami Yachiyo, a super masochistic, air-headed, friendly girl who loves cats. One day, after a fateful meeting, the two find themselves attracted to each other. In response to Inugami's instinctive approaches, Nekoyama is always bashful. Their friend Aki has to work hard to make jabs at some of the situations of the two, and also to stop Inugami from going berserk.
Yachiyo Inugami is a dog-like person who loves cats whilst Suzu Nekoyama is a cat-like person who loves dogs. Upon being introduced to each other by their mutual friend, Aki Hiiragi, the two take an instant interest in each other. Later, Yachiyo takes Suzu to her house to see her three pet dogs.
A beautiful ghost makes herself known.
Yachiyo brings in some tea spiked with catnip, hoping to make Suzu drink it and become docile and affectionate. However, when the tea is spilled on Suzu as a result of Aki's attempt to stop Yachiyo, she behaves in a more lewd manner than expected.
Yachiyo gets to know her classmate, Mikine Nezu, who displays a lot of mouse-like tendencies. Later, Mikine takes Yachiyo and Suzu to the biology club to meet her upperclassman, Yukiji Ushikawa, who is much like a cow.