Hazbin Hotel is the story of Charlie, the princess of Hell, as she pursues her seemingly impossible goal of rehabilitating demons to peacefully reduce overpopulation in her kingdom. She opens a hotel in hopes that patients will be "checking out" into Heaven. While most of Hell mocks her goal, her devoted partner Vaggie, and their first test subject, adult film-star Angel Dust, stick by her side. When a powerful entity known as the "Radio Demon" reaches out to Charlie to assist in her endeavors, her crazy dream is given a chance to become a reality.
In a vain attempt to stop multiple governmental genocides, Charlie, the princess of hell, opens up a brand new hotel to "help rehabilitate sinners" with her partner Vaggie. They first attempt to rehabilitate Angel Dust, a gay porn star. His rehabilitation and his actions put the hotel on dangerous ground. With a motley crew of co-workers, Charlie and Vaggie open up the happy hotel, later deemed by Angel Dust to be the Hazbin Hotel. Trouble seems to be amidst when the mysterious Radio Demon takes notice of the Hazbin Hotel.