In this supernatural crime series, Seth Gecko and his violent, unpredictable brother, Richard "Richie" Gecko, are wanted by the FBI and Texas Ranger Freddie Gonzalez after a bank robbery left several people, including policemen and Gonzalez's mentor Texas Ranger Earl McGraw, dead. Heading for the Mexico border pursued by Gonzalez, the Geckos encounter former minister Jacob Fuller and his family, whom they take hostage by commandeering the Fuller's RV. Drug lord Don Carlos reroutes them to a strip club populated by vampires that all must fight until dawn in order to survive.
The Gecko brothers are wanted by the authorities after a bank heist leaves several dead. Escaping to mexico, chaos ensues when they take hostages and detour to a strip club that is populated by vampires.
In season two, core relationships deepen and become more complicated as everyone tries to put their lives back on track after one very insane day. Santánico and Richie (living outside of Houston) are now partners in crime, resembling a more modern version of Bonnie and Clyde; Seth and Kate are scraping by as small time criminals south of the border; and Freddie Gonzalez has an almost obsessive focus on protecting his wife and young daughter in the suburbs. Carlos Madrigal and Scott Fuller emerge from the Titty Twister, changed men. They will all come together once again – this time facing off against an even bigger threat.
In season three, the Gecko brothers find themselves in the vortex of the Culebra world, thrust into a fight against the forces of hell. The Geckos assemble an unlikely crew to take on the new enemies determined to take them down.