Widowed pediatrician Harry Weston is a miracle worker when it comes to dealing with his young patients, but he's more challenged by the other people surrounding him: daughters Barbara and Carol; his wisecracking office assistant, nurse LaVerne Todd; and obnoxious neighborhood mooch Charley Dietz. Thank goodness he always finds a friendly shoulder (and a warm, wet tongue) in Dreyfuss, his enormous dog.
Harry befriends a young shoplifter while volunteering at a free clinic and brings him home. The boy, an uncontrolled diabetic, later runs away, taking the Westons furniture with him.
Harry sells his pediatrics practice to another doctor, who ends up firing Laverne. When the hospital sends Harry to check out an inner-city clinic, he ends up teaming up with the owner, Dr. Maxine Douglas, to keep the place open. Laverne joins them as nurse. Meanwhile, Sophia Petrillo moves back into nearby Shady Pines retirement home and drops by the Weston house.
Carol can't decide how to tell Patrick about her pregnancy. Laverne refuses to tell Maxine a secret.
Laverne's mother-in-law visits, unaware that Nick and Laverne are divorced. Charley tries to persuade Carol to make him godfather of the baby.
Carol reads her mother's old diary and thinks she wasn't wanted. Maxine is annoyed by a mime and a hypochondriac at the clinic.
When Maxine has a dental emergency, Harry steps in and gives an interview in her place, but the journalist makes the article sound as though Harry deserves all the credit for the clinic's success. Meanwhile, Charley falls for Dreyfuss' vet.
Maxine and Harry compete to sell opera tickets. After a series of false alarms, Carol gives birth to son Scotty while at the opera.
Carol joins a mother-daughter support group and ends up feeling that she is the worst mother in the world, especially after locking the baby in the car. Laverne thinks Maxine is dying when she mysteriously asks for time off after a check-up.
Laverne fills in for a friend at Shady Pines, where Sophia's boyfriend hits on her. Sophia catches the two together and thinks Laverne is stealing her man.
Charley plans to marry a waitress from a pancake house. When she finds out they have the same birthday, Laverne thinks that explains why she and Maxine are so much alike, which Maxine thinks is ridiculous.
Harry gets shot when a young boy brings a gun to the clinic. Carol has a date with a famous anthropologist, who opts instead to go party with Charley.
Charley ends up working at his brother's used car lot, but when he makes a big sale his brother takes all the credit. Maxine and Laverne become competitive when they start jogging to get in shape.
Laverne's old biker boyfriend returns and the two rekindle their romance, which annoys Harry, who doesn't think the guy is good enough for her. Carol makes a memory video for baby Scotty.
After receiving an inheritance, Charley assembles a group of people who have meant a lot to him over the years (which includes Harry, Carol, Sophia, and Don Adams from Get Smart) and takes them all on a trip to Mardi Gras. Laverne's hideous looking cat dies.
Maxine's boyfriend, an African cultural attache, proposes marriage. Sophia and Charley get Carol (who meanwhile has started to play the guitar again) hooked on the dog races.
A wealthy philanthropist eyes Harry. Carol tries to help shy Doris (who once volunteered at the clinic but now sales roll-on moose door-to-door) come out of her shell.
Harry fills in at his old practice and becomes smitten with the nurse. Laverne is upset because Harry forgets the anniversary of the day they started working together.
Harry persuades his old jazz idol Sonny Baxter to come out of retirement and play at a benefit. Strange things start happening after Sophia vows revenge on Charley for dumping her niece.
Carol is upset when her childhood friend returns and starts dating Harry. A patient at the clinic turns out to be a member of the family which has feuded with Laverne's for years, which sparks a mini-war between the two.
When their good-for-nothing landlord refuses to repair the problems at the clinic, Laverne threatens a rent strike and ends up getting the gang evicted. Meanwhile, Sophia convinces Carol to spend some time away from baby Scotty but she can't seem to bring herself to let him out of her sight.
Rumors fly after Charley and Laverne begin spending a lot of time together, but the two swear they are just friends. Carol is excited about her new job at a local newspaper, until she finds out that she has been hired merely as a driver for the paper's teenage reporter.