With Majin Boo defeated half-a-year prior, peace returns to Earth, where Son Goku (now a radish farmer) and his friends now live peaceful lives. However, a new threat appears in the form of Beerus, the God of Destruction. Considered the most terrifying being in the entire universe, Beerus is eager to fight the legendary warrior seen in a prophecy foretold decades ago known as the Super Saiyan God. The series retells the events from the two Dragon Ball Z films, Battle of Gods and Resurrection 'F' before proceeding to an original story about the exploration of alternate universes.
Goku and Vegeta recruit Piccolo and Majin Buu as the remaining combatants of the Universe Seven team. Gohan considered joining, but was unable to do so as he had a business meeting on the day of the tournament. Beerus and the others think back over recent events, with a series of flashbacks recapping the series.
Goku visits Master Roshi only to discover he is currently at Tien's dojo as an honorary master. Visiting Tien and Master Roshi, a girl visiting the dojo puts his students under a spell and they start attacking the nearby village!
Even after Catopesra enters his ultimate mode, he barely keeps himself from being knocked off the field by Vegeta before something pushes him off. The same entity nearly does the same to Vegeta and Gohan, with Picolo saving the latter, revealed to be an invisible fighter while attacking Android 18. The fighter is revealed to be one of the two missing Fourth Universe fighters Gamisalas, who Piccolo quickly eliminates once Gohan creates a dust cloud to expose him. Undaunted, Quitela orders his remaining fighters to step up their game, Xiangca generating a dome that envelops the Seventh Universe team and manifests illusions of the erased universes' defeated fighters which Damom uses to attack through. With Seventh Universe team assuming Damom to also be invisible, Piccolo eliminates Xiangca upon seeking him but gets eliminated by Damom after his attacks failed to hit him. Android 17 eventually realizes that Damom is a fast-moving insect alien to explain how none of his team could hit him.
With all guests now gathered except for Goku and Vegeta, Bulma's birthday party gets underway. Trunks shows Goten where his mother hid the bingo tournament grand prize – the Dragon Balls. Not far off from the ship, the Pilaf Gang are now poor and hungry. They are trying to get by until they find the Dragon Balls and make their wishes come true. When his Dragon Radar picks up a signal coming from Bulma's ship, Pilaf and his henchmen hastily board the ship with Trunks and Goten's help. Meanwhile, on his planet, King Kai explains Beerus to Goku as a counterpart to the Supreme Kais who helps maintain universal balance. Just as he finishes, Beerus and Whis arrive.
With Earth no longer in danger, Goku and the others return to their ordinary lives. But Goku ends up working as a farmer again after Chi-Chi spent a majority the 100 million Zeni they received from Mr. Satan in light of Goku needing to becoming a role model for his unborn grandchild. Meanwhile, Mr. Satan's self-promotion as the one who defeated Beerus goes awry when alien ambassadors from planet Snak came to give their gratitude before their champion Galbee challenges Mr. Satan. After being unable to call Gohan or the others for help, Mr. Satan tries to enlist Goku's help when he arrives at the scene. Goku is forced to escape when Chi-Chi spots him about to fight, which forces Mr. Satan to deal with Galbee himself to maintain his image. Luckily, the aliens having intended to conquer Earth, the Snackians are revealed to be cynophobic as they leave Earth in terror upon spotting Mr. Satan's dog Bee.
17 declines Goku's invitation to fight in the tournament. While discussing, poachers quickly arrive and steal the Minotaurus from the island. It's up to 17 and Goku to rescue it.
Goku and the others arrive at Capsule Corporation to discuss who should be on the team, Beerus still refusing to tell Goku the truth about Monaka while claiming him to be too sick to participate, and agree to enlist Earth's fighters. Goku and Gohan agree on Majin Buu, Vegeta, Piccolo, Krillin, Master Roshi, Android 18, and Android 17 for a total of nine, ruling out Trunks and Goten for their inexperience. They proceed to ask Vegeta, who has thought up a name for his unborn child and still refuses to participate in the Tournament of Power while Bulma is pregnant. Whis uses his time warping ability to speed up the infant's birth so Vegeta can participate, with everyone celebrating while Vegeta develops an attachment to his newborn daughter. While upset that he couldn't name her Eschalot, he settles for Bulma's naming their child Bulla. Goku leaves to recruit team members, starting with Krillin and 18.
Beerus and Whis arrive on King Kai's planet and detect Goku's presence, the former initially disappointed that Goku knows nothing about the "Super Saiyan God" yet agrees to test his strength in a sparring match. Goku attempts to fight him in all of the Super Saiyan transformations, but Beerus effortlessly defeats him in two blows. Beerus and Whis head for Earth shortly afterwards, while King Kai uses his telepathy to warn Vegeta ahead of their arrival and ensure Beerus does not get upset.
Having powered up, Vegeta charges towards Beerus but is knocked out when the Destroyer is revealed to have been using only a fraction of his power. While the Pilaf Gang disembark Bulma's ship on a stolen life raft, Beerus decides to give the Earthlings another chance at saving their planet and picks out Oolong out his similar appearance to Buu for a game of rock–paper–scissors to decide the fate of the planet. After a couple ties, Beerus eventually wins and proceeds to power up his attack. Just as Beerus is about to fire, Goku chimes in and requests Beerus to give them a reprieve as he thought of a way they can get a Super Saiyan God. He will summon and ask Shenron about it.
Fearing what might happen knowing that Beerus is awake, the Old Supreme Kai and Kaibito urge King Kai to ensure that Goku never finds out about the Destroyer. But Goku overhears the conversation and becomes curious. Back in his temple, Beerus and Whis continue their search for the Super Saiyan God. They soon learn of Goku and his feats. Beerus and Whis decide to pay him and King Kai a visit. Meanwhile, back on Earth, Goku's friends and family members begin gathering on the cruise ship for Bulma's birthday party except for Vegeta who is still training to surpass Goku as the strongest Saiyan.
Sometime after peace returns to Earth after the defeat of Majin Buu, Goku is forced by Chi-Chi to work as a farmer. Goten and his friend Trunks search for a gift for his sister-in-law Videl, who is married to his older brother, Gohan. Unable to afford jewelry or makeup, the two decide to visit a hot springs in the woods to bottle up some mineral water instead. While there, they are attacked by a giant snake, which they manage to scare away. Sometime later, Mr. Satan visits Goku and gives the 100 million Zeni he received for his purported role in saving Earth from Buu. Goku gives the money to Chi-Chi, so she would let him train. Elsewhere in deep space, Beerus the Destroyer awakened from dreaming of a worthy opponent as he and his attendant, Whis set out to discover who this figure is.
Beerus and Whis arrive on Earth as Bulma's birthday party is underway. Paralyzed by Beerus' presence, Vegeta recognizes him as the being who once visited Planet Vegeta and forced his father, King Vegeta on his knees. Bulma pops up and assumes Beerus and Whis to be Vegeta's friends as she invites them to join the party, the two gladly accepting her offer as they become enamored with Earth cuisine. Though Vegeta tries his best to ensure that Beerus remains calm as he and Whis mingle with the guest, the Destroyer becomes furious when Majin Buu refuses to share the remaining pudding and attacks him for his insolence.
As Goku goes to King Kai's planet to train, Vegeta, Bulma, and Trunks take a family trip to a resort. Bulma and Trunks are enjoying the family time together, while Vegeta is bothered by the fact that Goku gets to train. Fed up with what he considers a waste of time, Vegeta flies away and heads back to Capsule Corporation to train. Somewhere in space, Beerus and Whis scour an alien planet in search of dinosaur meat. They are confronted by the planet's strongest dweller, whom Beerus overpowered before effortless destroying the planet. At that time, Beerus has another vision of his destined opponent – the Super Saiyan God.
Beerus effortlessly knocks Majin Buu away, telling Vegeta to step aside when was being persuaded to calm down and enjoy himself. Trunks and Goten fuse into Gotenks, only to be outmatched and then punished by Beerus after insulting his pudding obsession. Beerus then defeats Piccolo, Tien Shinhan, and Android 18 before he and an upset Buu clash again. While observing the battle, Dende realizes what Beerus actually is and immediately informs Piccolo. Before Piccolo is able to warn him, Gohan powers up and charges towards Beerus before the Destroyer uses Buu as a weapon to knock Gohan down before tossing Buu aside. Vegeta attempts to stop it, but is forced to the ground by Beerus who expresses his disappointment of him being as weak as his father was. Just as Beerus is about to finish Vegeta, Bulma walks up and slaps him for ruining her party. Beerus retaliates with a backhand, with Vegeta finally losing his temper from seeing Bulma hurt and powers up immensely.
Initially refusing to help Bulma after forcing him to come to Earth, Jaco suggests inquiring about the Super Dragon Ball from an omniscient alien named Master Zunō. After arriving on Master Zunō's planet, Jaco failing to mention the seven-year waiting period, the duo encounter a spacefaring criminal named Burpman, who is wanted by the Galactic Patrol for multiple dine and dash crimes. Having accidentally destroyed a monument and pinning the blame on Burpman, Jaco eventually decides to arrest the criminal so he and Bulma can take his spot and seek Master Zunō's advice right away. While Bulma unwittingly wasted two of her three questions, she learns the radius and other properties of the Super Dragon Balls as well as that they were formerly scattered across both the Sixth and Seventh Universes.
Super Saiyan God Goku confronts Beerus, amazed by the immense power his body has gained with the transformation as he gradually becomes used to his new form. Seeing as how Goku might turn out to be a worthy adversary after all, Beerus decides it is time for them to unleash their true power and have a real battle of Gods.
Due to over exerting himself from using the Kaiō-ken technique against Hit, Goku has problems controlling his energy and is force to take break to regain his strength. While Gohan and Videl are out, Goku and his family babysit Pan with the infant being fascinated with the stars. That morning, the Pilaf Gang attempt take advantage of Goku's powerless state with a giant robot, but they end up unintentionally stealing Pan while their robot turns into a ship that they accidentally launch them into the stratosphere. The pressure from the launch destroys their ship, but Pan is able to fly back home with her captives in tow. On their way home, Goku's family is relieved to find Pan even though they remain ignorant of her exploits.
While Bulma and her team are still repairing the Time Machine, Future Trunks finds Piccolo and Krillin mending the damages in the wake of Goku's fight with Goku Black. Future Trunks learns from Piccolo that Gohan had become a scholar and is convinced to properly thank Gohan for his alternate self teaching him to fight. Future Trunks meets Gohan at the university before being invited to Gohan's house for dinner, the experience renewing his resolve to stop Goku Black. Future Trunks returns to the Capsule Corporation, learning that Goku, Beerus, and Whis have left to another universe to investigate the mystery behind Black's energy signature.
Goku and Beerus continue to fight in space, their clashing blows revealed to be producing shockwaves then are causing the universe to be undone, Old Supreme Kai assuming that two more such blows could destroy everything. However, Goku manages to land the third clash with Beerus by balancing Beerus' attack with his own to prevent any more shock waves to be produced. Beerus then uses his atomic bomb attack on Goku, who counters with a Kamehameha.
Goku gathers the Dragon Balls together and summons Shenron, who is startled upon learning of Beerus' presence. Shenron quickly explains that the Super Saiyan God is a legendary transformation that results from a ritual where six kind hearted Saiyans infuse their power into another. The Saiyans attempt to transform Goku, but they fail as they are one Saiyan short. An impatient Beerus was about to destroy the planet when Videl offers to join the ritual while revealing to be pregnant with Gohan's unborn child. The Saiyans and Videl attempt the transformation again and manage to transform Goku into the Super Saiyan God.
Now with only a Super Saiyan form at his disposal, Goku powers up and attacks but to no avail as Beerus knocks him out effortlessly. With Goku knocked out, Beerus prepares to destroy Earth. In a final effort to stop Beerus, Goku once again powers up and charges his Kamehameha attack. Goku manages to prevent Beerus' attack, but he completely depletes what was left of his energy in the process. He comes crashing down to Earth onto Bulma's ship, where Vegeta manages to catch him. Beerus lands on the planet shortly after to finish what he started, but he suddenly falls asleep. Whis explains that Goku must have tired Beerus out and that by the time he wakes up he will have forgotten about their trip to Earth. Beerus who was faking his sudden sleep spell and Whis leave for Beerus' planet shortly after. With Earth safe again, Goku decides to relax and enjoy the party.
Goku and the android girl Arale Norimaki meet after many years, in a fun-filled episode where the cast of Dr Slump and DBZ meet.
The Supreme Kais are surprised that the universe is still intact following the battle, Old Kai assuming it to be Beerus's doing and fears the worst has yet to come. On Earth, Vegeta, Whis, and the others are still observing the fight with Whis impressed by the power a Super Saiyan God has. In space, Goku struggles to keep up with Beerus' attack, which ultimately ends up in a massive explosion that threatens the universe before Beerus used his full power to negate it with Mr. Satan taking the credit when called by his public relations group. Goku and Beerus continue their fight after the latter tells the mortal he is at his limit, Goku transforming back into a Super Saiyan after losing his divinity. With Goku not realizing he lost his Super Saiyan God form until after, he managed to land a hit on Beerus who deduces his opponent can still fight on equal ground they resume their battle.
Having somewhat got a grip on the Super Saiyan God form, Goku initially manages to keep up with Beerus before realizing the Destroyer is holding himself back as means to motivate Goku to catch up with him. To that end, Beerus drags Goku to space, where he swiftly knocks him out. Goku comes crashing down back to Earth and ends up in an ocean. Amazed by such power, Goku gets excited and powers up, and heals himself in the process. Willing to have another go, Goku flies out of the ocean and dashes towards Beerus.
While each of the Universes prepare for the Tournament of Power in their own ways, Universe 7 gets in a pinch when they learn Majin Buu will be unable to enter the competition.