In the town of Fairview there's a street called Wisteria Lane; a peaceful cul-de-sac with manicured lawns and beautiful houses. It's a place where you know all your neighbors and your neighbors know all about you. It's the perfect suburban fantasy. But, behind every picket fence there are secrets. And, in every seemingly happy home, you'll find jealousy, lust, passion, and sometimes... murder.
Susan tries to impress a teacher at work, Gaby talks Carlos into hiring Lynette, Edie continues to look into Dave's past.
Susan believes that Katherine may be Julie's assailant. Angie invites reluctant Bree and Orson to dinner. Gaby struggles to home school Juanita. Lynette has her own suspicions about who attacked Julie. Angie confronts Nick.
Losing Mike takes its toll on Katherine. As Katherine unravels, Bree comes to her aid; Gaby grows weary of John’s intentions towards Ana with twins on the way, Lynette calls upon her family to step up around the house Susan learns Julie has been harboring some secrets and Angie throws a party for son, Danny.
A chance encounter reunites Gaby with her sexy ex-lover and gardener, John Rowland; Bree contemplates a weekend getaway with Karl; Lynette and Tom break the news to their kids that she's pregnant again; and Susan is convinced Angie's son is responsible for her daughter's attack.
Bree and Katherine decide to start a catering business together. Lynette tries to deny her feelings for Rick. Mike learns the truth about his nearly fatal accident. Carlos gets a seeing-eye dog. Dylan meets her estranged father.
Bree's estranged daughter, Danielle, returns to Wisteria Lane and is met with a deluge of criticism. Meanwhile, Gabrielle and Susan find themselves embroiled in a catfight brought on by an altercation between their kids. To her chagrin, Lynette comes home to find Tom and Dave have formed a garage band after she told him to get rid of his old things. Finally, Katherine and Mrs. McCluskey invite Edie to lunch to press her for more information on Dave.
Susan and Edie accidentally lock themselves in a basement; the search for Porter leads Lynette to her mother; Mike and Katherine define their relationship; Dave gets closer to exacting revenge.
Mrs. McCluskey falls for a steak salesman called Roy Handler. Julie is found unconscious in the park bushes, which questions Mrs. McCluskey's decision to tell the police that she saw Angie Bolen's 19-year-old son, Danny, fighting with Julie.
Gabrielle and Carlos head to Texas to visit Gabrielle's stepfather's grave; Lynette prohibits Porter and Preston from bringing home girls; Renee tries to use Susan's dialysis to help her get into a restaurant, but fails.
Bree goes to extremes to hide her true intentions from Orson, while Susan and Jackson put on an act for the authorities. Lynette is shocked at the lengths Tom will go to in order to look younger, and Katherine masks the truth from Mike, afraid to lose him. Meanwhile, Dave is on edge when he learns a key witness to his misdeeds surfaces.
Bree's new found success causes the rest of the women on Wisteria Lane to feel envious. Lynette longs to return to her days as an ad-executive, and finds an outlet as Bree's marketing manager. Mike feels that he is not a big enough presence in his son's life after M.J. draws a family portrait and leaves him out. Meanwhile, Gaby comes up with a way to have more sex with Carlos.
While in therapy, Gabrielle learns the truth about her past; Keith becomes suspicious about Bree's secret; Lynette's mother tells a lie to a coroner about Frank's death; Mike confronts Zach about Paul's shooting; someone makes arrangements to give Susan a new kidney.
Bree begins to fall for Karl and drifts further from Orson. Katherine continues her sad attempts at seducing Mike, as her conflict with Susan grows. Gaby gets Juanita expelled from school. Lynette learns Tom is cheating on his mid-term, and Angie hides the truth about her mother.
Mike gets married and his bride is finally revealed will it be Katherine or Susan? Meanwhile, Lynette deals with the realities of being pregnant again; Bree works to break free from Orson; Gaby is tested by Carlos' niece who continues to stay with them; and a new family with dark secrets moves to Wisteria.
When Juanita’s party is on the verge of being ruined after Gaby is deemed a bad mom, Gaby is determined to prove she’s a responsible parent. Bree gets defensive when she’s judged by a motel maid for having an affair with Karl. Lynette is put off by her new handyman when he defers to Tom for approval on all things and Susan and Katherine come to blows over Mike. Meanwhile, a lapse in judgment on Danny’s part leads to a terrible mishap that Angie and Nick must cover up.
Bree contemplates selling her business in order to revive her marriage. Meanwhile, Lynette is threatened at work; Katherine is caught in an unforseen circumstance; and Edie's worst fear begins to come true.
For Gaby and Carlos, injuries sustained in the fire lead to a fortunate discovery. But for most, the consequences are less forgiving. Lynette and Tom vow to protect son Porter at any cost. Susan must learn to let go of the man she loves. Orson's attempt at a good night's sleep puts Bree in a most precarious, though amusing, position on the day of her big cooking demonstration.
Unaware of Jackson's whereabouts, Susan goes to a local bar suspecting that he might be with Mike however, she soon lands herself in-trouble; meanwhile, after spending money that did not belong to her, Gabrielle attempts to get Carlos to get a job at the local country club as it pays better. Bree promotes her cook book on a radio show.
Angie comes face to face with her ex, Patrick Logan, after years on the run. Meanwhile, Gaby and Susan plan an elaborate scheme against their husbands, Lynette sees a darker side of Eddie, and Bree meets a woman who knows Sam all too well.
The residents of Wisteria Lane all attend the unfortunate funeral of Juanita Solis as Carlos and Gabrielle fret over their financial and court issues. Lynette befriends a deaf woman, Alisa Stevens, whose children also attend Barcliff Academy with Porter and Preston, but her newfound friendship is quickly put to the test. Meanwhile, Bree encounters more trouble with her son Andrew when it comes to disciplining him and lastly, Susan finds herself attracted to Edie's hunky new contractor, but Edie doesn't want her to go with him as a favor to their fragile friendship.
Gabrielle runs into an old acquaintance who's lost everything, Lynette is upset with Tom for his latest "bright idea," Orson threatens to blackmail Bree, and Susan accepts Dave's "friendly" gesture.
Carlos finds Lynette in a precarious position, which she chooses to hide from Tom, and Gabrielle hastily covers for Tom's coy behavior. Orson tries to hide the truth about his wounds from Bree, while Katherine confesses to Mike, which leads to a surprising realization. In the meantime, Susan confides her dark secret in Dave.
Edie becomes the subject as the other housewives reminisce about her: with Susan recalling the first time they met; Lynnette remembers an unforgettable night; Gaby remembers an evening of friendly competition; and Bree remembers how thoughtful she was towards Orson.
Lynette balks at the idea of seeing a couples' therapist. Meanwhile, Katherine is seeing her own psychiatrist, Gaby and Susan are determined to find out which of if their kids are in the smartest group at school, and Angie disapproves of Danny's new girlfriend.
Susan's mother and aunt visit her at the hospital, Lynette plots revenge against Tom, Gabrielle becomes increasingly obsessed with getting Grace back and Bree wants to be friends with Beth.