The BEST episodes of Complications

Every episode of Complications ever, ranked from best to worst by thousands of votes from fans of the show. The best episodes of Complications!

John Ellison, a disillusioned suburban ER doctor, finds his existence transformed when he intervenes in a drive-by shooting, saving a young boy's life and killing one of his attackers. When John learns the boy is the son of an influential gang leader and is still a target, he is compelled to save him at any cost. John soon discovers that his own life – and his outlook on medicine – may never be the same.

Last Updated: 12/9/2025Network: USA NetworkStatus: Ended

8.26

227 votes

#1 - Infection

Season 1 - Episode 2 - Aired 6/18/2015

John scrambles to locate Antoine when the boy disappears from his bed at the surgical center. Polk tries to convince a patient to lie about her medical condition in order to keep John out of their supervisors' crosshairs.

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8.15

227 votes

#2 - Relapse

Season 1 - Episode 8 - Aired 7/30/2015

John tries to rein in his compulsions, but is tested when he's tipped off about an impending massacre. Samantha turns to Det. Holden for answers.

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8.12

284 votes

#3 - Pilot

Season 1 - Episode 1 - Aired 6/18/2015

Disillusioned ER doctor, John Ellison saves the life of a young boy when he intervenes in a drive-by shooting and ends up in the middle of a gang war.

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7.91

254 votes

#4 - Immune Response

Season 1 - Episode 4 - Aired 7/2/2015

Gretchen makes expensive arrangements to hide Antoine in order to prevent Bridget from learning that John illegally transferred him to the surgical center. However, that means John needs to ask the gang for money. A past indiscretion tests John's relationship with Samantha.

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7.85

259 votes

#5 - Onset

Season 1 - Episode 3 - Aired 6/25/2015

John visits Antoine's father, the leader of the VCC gang, in prison, and tries to disentangle himself from his responsibilities with Antoine. Things get out of control when Gretchen confronts Hillary's abusive boyfriend at his home.

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7.67

202 votes

#6 - Fever

Season 1 - Episode 7 - Aired 7/23/2015

John wants to help Gretchen, but doesn't want to circumvent the law. Samantha's doubts about John are increased by information provided to her by Kyle.

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7.66

201 votes

#7 - Critical Condition

Season 1 - Episode 10 - Aired 8/13/2015

John and Gretchen try to take Antoine home, but an unexpected complication forces John to do everything he can to save the youth—and his own family.

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7.64

198 votes

#8 - Deterioration

Season 1 - Episode 9 - Aired 8/6/2015

Holden forces John to testify against the Latin gang; and Samantha's past threatens her marriage.

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7.63

139 votes

#9 - Diagnosis

Season 1 - Episode 6 - Aired 7/16/2015

Det. Holden of the Gang Task Force questions John about his suspicious activity. Gretchen travels to the gang neighborhood to save a young boy.

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7.60

205 votes

#10 - Outbreak

Season 1 - Episode 5 - Aired 7/9/2015

A gang shootout results in a flood of victims in the ER. John tries to halt the escalating violence, but to succeed he must navigate rival gang members and the police. Gretchen tends to the young woman who sparked the bloodshed.

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