When their home planet, Mars is on the verge of destruction by the Plutarkians- a species of fish-like aliens who are searching for resources from other planets, a bunch of Humanoid Mice escape their world. Throttle, Vinnie, and Modo, a trio of Biker Mice from Mars were shot down by a Plutarkian Ship, and crash landed on Earth. In Chicago, Illinois, they become allies with a human mechanic named Charley. The Mice discover that the Plutarkians have started to make their move on the Earth. The Biker Mice quickly investigate, and discover that one of the city's leading citizens, Lawrence Limburger, is actually a Plutarkian in disguise, who is sending the land back to Plutark.
When Modo is covered in toxic substances, Limburger escapes with his bike. Modo does not want to rest while Charley and the guys rescue his bike.
Limburger hires Evil Eye Weevil to reign chaos on the town, causing mischief and mayhem and succeeds in driving the trio apart.
The Biker Mice realize that Limburger is not the only evil character in town, when they attempt to stop a bank robbery. Vinnie must descend into the Pits to save his brothers from the Pit Boss.
Two of the Biker Mice are injured when a new gang arrived in town, and stole all the gas.
In order to steal all the steel from the town, Limburger offers Modo a new arm to work for him.
The Heavy Metal mouse that the mice despised on Mars, heads into Chicago, but with an all-new attitude.
With the Pulverizer on his side, Limburger decides to steal the newest piece of military destructive weaponry.
After losing his funding, Limburger has a wonderfully devious plan to get back in the High Chairman's good graces, and this leads the mice and Charley in a race to save a national monument.
Limburger's old Plutarkian rival, Napoleon Brie arrives on Earth to try and take over operations.
Limburger's new plan is to literally cut the city free from the Earth and eject it to Plutark.
The mice and Charley must race to save the Last Chance when Limburger manages to get the building legally condemned.
The Mice must now face Limburger's latest machine from annihilating Mars. The machine attracts asteroids to the planet, to bring complete destruction.
They still have to roost Napoleon Brie from Chicago where he's taken over in Limburger and the mice's absence.
The mice are put on trial for their crimes against Limburger.
Limburger decides to lure the Biker Mice into a trap that will put them against several villains. This would make Limburger gain access to Vinnie's Motocross title as the prize.
A female bounty hunter is present in the Windy City, ready to defeat some evil.
The mice are cast as stuntmen for a film, shooting in the local area, but problems with the star and the director, healthy plans for the filming locations make for a dangerous day on the job.
While Rimfire and Stoker arrive on earth with a typical Martian male landing, Limburger creates a new scheme to brainwash everyone using shampoo. But the Mice are in trouble when Stoker seems to have lost his fighting abilities.
When Limburger disappears mysteriously, his unintentional replacements turn out to be increasingly more powerful and evil.
The Biker Mice must stop Limburger's plan to ruin not only Christmas, but winter too, and save an orphanage.
Throttle, Modo and Vinnie...The Biker Mice from Mars...escape their planet as it it devastated by the fish faced plutarkians. Crashlanding in Chicago, the renegade rodents soon discover the Plutarkians next target: EARTH. Led by his supreme chessiness, Lawrence Limburger, and his devilish cohorts, Greaspit and the fiendish Dr. Karbunkle, the Plutarkians are already undermining the Windy City. It's tail whippin' time 'cause the baddest motorcycle mammajammers in the universe are riding to the rescue.
Limburger frames the mayor's kidnapping on the Biker Mice, so he can take over the city.
When a new theme park opens - Cheesyland, Limburger decides to hide his mining operations there, so it's up to the guys to make sure that Cheesyland doesn't leave the Windy City full of holes.
When, Limburger takes over as warden for a prison, Charley and the Mice find out a way to stop him, by trying to get into jail.
When intergalactic game hunters catch Modo's nephew Rimfire, he manages to escape in their ship and finds himself on Earth.