Big Shots is a drama from Warner Brothers Television and ABC about four friends who are up and coming executives. James is played by Michael Vartan and is the "moral center" of the group. He's married to Stacey, and they've been together since freshman year in college, but their marriage is in trouble. He just found out she was having an affair with his late boss. He relies on his "work wife", Katie, played by Nia Long, to keep him focused in the office. Dylan McDermott plays Duncan Collinsworth. a cosmetics CEO. He's divorced from Lisbeth, played by Paige Turco, but things aren't completely over. Even though he still seems interested, she knows if she took him back he'd lose interest immediately. They have a 19 year old daughter Cameron (Peyton List), who resents her father for walking out on them. Christopher Titus plays Brody, a married graduate of Harvard Business School, who spends more time trying to make his wife happy than running his business. Joshua Malina plays Karl. He's married to Wendy, played by Amy Sloan. They are seeing a marriage counselor, but he has a secret mistress on the side, Marla, played by Jessica Collins. What is he going to do when Marla and Wendy become friends? More than business associates, these four men are best friends who will be there for each other no matter what.
James is worried about his kids spending time with Wendy's new boyfriend. Duncan and Lisbeth have a romantic weekend planned but he has to postpone it because he's being blackmailed over Dontrelle's black book. The therapist tells Karl and Wendy they need to be intimate.
James and Katie cannot agree on whether to divulge their budding relationship. Meanwhile, a public-relationship problem has Duncan and Terrance at odds. Also, Brody is undecided about going to bat for a ballplayer.
James gets involved with a new consultant that has big changes in mind for Amerimart, which doesn't make Katie happy. During fashion week Duncan catches up with an old flame, while trying to stay true to Lisbeth. Karl tries to fix Marla up with someone from his work. Brody tries to get Dontrelle's book before Terrance does.
Duncan tries to get his CEO title back at Reveal. James and Stacey get involved in a custody battle when she decides to move to California. Karl has to deal with his old high school bully who wants to join Firmwood. Brody feels the need to compete for Janelle when he find old love poems written to Janelle by others.
As Lisbeth and Terrence prepare for their wedding, Duncan focuses on business and trying to get a supermodel from a rival company. James thinks the wedding is a good opportunity for him and Katie to have a real date. Brody finds himself attracted to Heather when he's sick and tired Janelle's nagging. Cameron finds out the truth about Zack.
James is back to dating but finds it's not as easy as it used to be. After Dontrelle is arrested Duncan asks Brody to help him get Dontrelle's little black book which mentions Duncan. Karl and Marla get worried when they find out that Wendy has hired a private investigator who now has photos. Terrence offers Cameron a job which doesn't set well with his rival Duncan.
Duncan's not happy when he finds out Lisbeth and Terrence are getting serious. He's not about to give up and tries to win her back. James finds himself attracted to the anchor of a TV business show. Karl gets worried when Wendy says she wants to have a baby, she didn't handle it well when they tried in the past and didn't work out. Cameron has a new co-worker.
In order to make a great deal for his company Duncan asks for Cameron's help so he can look like the perfect dad. James tries to get his new girlfriend and Katie to get along. James know some information about Katie's boyfriend but doesn't know if he should tell her or not. They guys don't like Brody's father-in-law, who comes by to visit. Karl's not sure what to do when Wendy tells him she wants him to sleep with Marla so they can have a baby. Zach has some surprising news for Cameron.
James makes a decision regarding his marriage. Duncan comes up with a way to stop the reporter from ruining him, he tries to seduce her. Wendy wants Marla to go to couples therapy with her and Karl. Brody tries to put the spark back in his love life. Terrence Hill shows up and is out to get Duncan no matter what it takes.
Duncan and Lisbeth are divorced but still sleeping together. Duncan gets jealous when she goes out on a date. James finds out his wife Stacey had been having an affair with his late boss. Brody is planning a party for his wife at her request. Karl and wife Wendy are seeing a marriage counselor, but what she doesn't know is that he's having an affair with Marla.