While helping the Army deliver cattle to an Apache tribe, Favor, Wishbone and Quince run into a band of renegade Indians determined to stop them.
Straw Coleman is caught trying to steal a horse and saddle while in chains. The drovers are shocked when Wishbone pulls a gun on them and helps Coleman escape. Favor and Mushy go after them to find why Wishbone has strayed.
Don Francisco Maldonaldo sentences Favor and Rowdy to die for the death of his son.
Wishbone develops a mysterious blindness after a scary encounter with a dangerous cliff and an innocuous fall. A doctor finds no physical reason for the blindness. A psychological reaction to childhood trauma is suspected as the cause.
When Wishbone and Mushy realize Hannibal is not safe they try to help. They are brought back tied up while Hannibal is tarred and feathered. Hannibal returns to Deadhorse and the men want to help him against Favor's better judgment.
Carlock has been tracking an African lion for four years. Favor hires him to get the lion. Mushy wants to be a hunter.
The town's richest and most popular man is convicted and sentenced to be hung for the revenge murder of his son's killer. He is undaunted by this because he is counting on no one in town be willing to act as executioner.
Rowdy rescues nester Higgins from being used for target practice and gets involved in his fight to stay on his farm.
Favor and Clay are witnesses at a the wedding of Amy Gault and Frank Louden. Gus Marsdon provokes Frank into shooting Amy's brother Carl. Tom Gault, Amy's father, sends Ben Kerran after them. Frank and Tom claim the same 100,000 acres.
Mr. Fletcher offers Rowdy $6,000 to get 1500 head to Bent Fork in six weeks or less. There is a penalty of $30 for each head that doesn't make it. Lash Whitcomb, one of Fletcher's men is going along as Segundo (#2 man). Lash and Rowdy disagree on which trail to take. Rowdy checks his out. It leads to a box canyon. Rowdy's horse hits a chuckhole and he is thrown and breaks some ribs. Rowdy tells Lash to take over. Ten miles and three days from Bent Fork, Sheriff John Keeley, says there is a sixty day quarantine on Texas cattle.
Favor is pushing hard to outrun hoof and mouth disease just as he had seven years earlier. Pan an ex-circus performer searches for a lady he heard singing eleven years earlier.
A mine cave in traps Quince and Simon. New drover Ed says he's found some blasting gel and gun cotton. He and his buddy Jerry will blow them out for $500. It is a perilous journey hauling the unstable gel to the mine in a rickety old wagon.
Favor finds a woman, Lissa Hobson, still alive but not by much, and her baby, Tad.
On his way to Larned, Matt, feverish, spends the night at an abandoned shack. When he wakes up after losing a day, a recently released convict who swore to kill Matt, is himself found against a wall, dead, unarmed, shot twice, and the murder weapon appears to belong to the marshal.
Gil's old friend, Lije Crowning, has had his ranch foreclosed on by the bank. Lije wants to take his thirty head with the drive to Colorado.
A gypsy tells Wish's fortune he draws the death card three times.
In return for crossing her land to water, E.J. Farragut wants Favor to hire her grandson Billy.
The drovers have a Saturday off for the first time in a long time. To wake up the dead town. Rowdy and his friend Rabbit shoot at a schoolhouse bell. A bullet ricochets and kills Jud Hilton. His brother, Brother William, a tetched self proclaimed minister, puts a curse on them and say they can't outrun death.
A man called Flathead Joseph kidnaps the adopted daughter of a Cherokee chief and offers her to the Boonesborough settlers in exchange for a jug of rum. When it's revealed that the girl is in reality white, Daniel purchases her freedom. Then the Cherokee arrive on the scene and want to take the girl back to live with them. Some of the settlers do not agree that she should return but the girl herself wants to go
Rowdy hires wolfers Abner Cannon and his children.
Favor and Rowdy see two Cheyenne. They are watching a burying wagon. It's owner, Pomeroy K. Tollliver (Poke) surrenders to Favor thinking they're a posse. The wagon is broken. Favor will have the wagon fixed and Poke can ride to Rock City with the herd.
Favor tells Rowdy to let Lou Bowdart drive the herd up the San Marcos trail.