Eliza Thornberry is not your ordinary kid. It's not just because she travels the world in an RV with her parents, Nigel and Marrianne: famous nature show hosts. Eliza also happened to be granted the magical ability to talk with and understand animals. She's now able to talk with animals and help save them from various threats along with her friend Darwin, a chimpanzee who travels with Eliza and her family.
The Thornberrys get stranded on an uncharted island, basking at first in all the beauty and the splendor, but discover soon enough that being marooned isn't all it's cracked up to be.
After Eliza saves an arctic hare from a determined stoat, she learns that underdogs come in all shapes and sizes.
Eliza finds a hero in a giraffe who can see distances with his height and warn others of approaching danger. However, to Eliza's dismay, the giraffe leaves the animals for his own needs. Only when Eliza herself is in danger does the giraffe return and realize his selfishness.
When Eliza gets a hunch that foul play has led to Darwin's disappearance, she sets out to rescue her long lost companion. To her dismay, she finds Darwin has become one of the most popular acts at an Indian palace where a young prince lives. It's up to her to prove to Darwin that friendship runs deeper than the glamour and glitz of showbiz.
Eliza gets in over her head when she assumes responsibilities she can't handle. She is soon forced to don scuba gear and rescue a fumbling Nigel and a tumbling commvee under the dangerous waters of Australia.
When Eliza is told that ""Jake"" the turtle is the last one of his kind, she can't just let his species become another name on the extinction list. Enlisting help from other animals, she soon discovers ""Samantha"" and brings the two turtles together--blind date style. Eliza soon realizes that playing the role of cupid is not as easy as it seems.
When the Thornberrys are in Finland for the annual reindeer races, Eliza feels left out. She single-handedly uncovers a plot to sabotage the races, and along with an equally excluded reindeer who didn't make the final cut, helps save the day by playing fair.
When the Thornberrys leave Australia for India, Eliza can't bear to leave her wombat friend, Emily. Even though she is told not to, she brings her along. Now Eliza is constantly forced to re-create Emily's habitat in order to ensure her survival.
The Thornberrys discover that koalas are missing from their native groves. Eliza decides to unravel the mystery only to discover Kip and Biederman masterminding the evil plot. It is now up to her to stop the culprits from wiping out an entire species!
To study and protect the snow leopards from extinction and a construction site that is threatening their survival, Nigel's mentor (thought to be lost for many years) has left civilization to be a yeti. Eliza discovers his identity, helps him fend off the construction workers, and reunites him with her father.
Eliza convinces a group of baboon-like apes to stand up to their legendary adversaries--""The Others."" Darwin, meanwhile, has met an almost identical group of apes with an identical problem. As Eliza and Darwin lead their separate groups into battle, they suddenly find themselves face-to-face--in an all out war! Now it's up to Eliza to quickly find a way avert the battle and teach the apes to get along.
Eliza convinces a mother kangaroo that she can handle the responsibilities of baby-sitting. She quickly learns that this mischievous joey is more than meets the eye. After a close encounter with Tasmanian devils, Eliza is all too happy to relieve her duties and go back to being a kid herself.
Eliza and Debbie must take over Marianne's duties when she is sick. Debbie goes with Nigel to shoot footage of a condor and Eliza must care for Donnie. Covered with feathers from a pillow, Donnie is snatched up by the condor and Eliza and Darwin must rescue him and help the condor find her real baby. In return for the favor, the condors stay on a tree branch so Debbie can get footage of them.
With the commvee broken down in the desert and no water left to survive, the Thornberrys go through desperate measures to maintain their sanity.
The Thornberrys meet the Fensterkopfs who make false documentaries. The Fensterkopfs' kid lies to Eliza and gets them all stuck on a cliff. After the families barely escape an avalanche, the value of truth is learned by all.
When Eliza discovers that a local performer claims he can talk to animals she believes she's found a soul mate. Eliza must enlist the help of some very ""urban"" animals to sneak into the sideshow and meet ""The Great Bangaboo.""
When the girls discover that their parents have mistakenly taken embarrassing home movies to an awards banquet, they join forces in order to save face. Their cross-island trip turns into a race against time in order to beat their parents to the podium and stop the world from seeing them at bath time.
When a friendly polar bear is wrongly accused of vicious behavior, Eliza goes to great lengths to keep him from being harmed and learns the value of sticking by a friend in times of trouble.
When Eliza sneaks out ahead of her parents in order to find a rare Sumatran rhino, she discovers that to expose his life would only lead extinction of the species. Now instead of taking the prized rhino to her parents, she must try to keep them from filming it. And the bad news is, Nigel's already on its trail!
With Nigel and Marianne off exploring bat caves, Eliza and Debbie are left at the ""eerie"" residence of colleague Dr. Renfield. Eliza becomes bent on spooking Debbie, but when her imagination gets the best of her the tables are slowly turned. By the time their parents return, the girls are convinced that the absent-minded Renfield is a vampire out to get them!
Eliza and Debbie's combined bungling sends the commvee careening down a mountain, where it lies mired in the mud. They come face to face with a menacing-looking, but quirky tribe of silverback gorillas, and they must work together to ""unstick"" the van.
Eliza's good-natured intentions of assisting a struggling bird in getting food set off a chain reaction of destruction within the ecological system. It's up to her to retrace her steps and undo all of her actions while some animals face near extinction.
Eliza succumbs to peer pressure from a ""teenage"" elephant, which gets in the way of her closeness with Marianne on an overnight trip.
Eliza frees a hyena from captivity, but having never lived in the wild, it doesn't know how to survive. Eliza attempts to teach it, but it seems hopeless--until a wild boar threatens them and the hyena's natural instincts take over.
Eliza busts a young elephant out of a Kenyan game preserve, only to face predators and poachers who are out to get them.
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